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Last Updated: July 27, 2021

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CLINICAL TRIALS PROFILE FOR PEGINTRON

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All Clinical Trials for PEGINTRON

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00018031 ↗ Peginterferon Alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected Patients Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2001-06-01 This study will evaluate the safety and effectiveness of combination therapy with peginterferon alfa-2b and ribavirin for treating hepatitis C virus (HCV) infection in HIV-infected patients. In studies of patients with hepatitis C alone, interferon alfa-2b plus ribavirin treatment eradicated the HCV in almost half the patients. Peginterferon alfa-2b is a compound that results from attaching a polyethylene glycol molecule to interferon alfa-2b. This compound stays in the blood longer than unmodified interferon alfa-2b, causing a higher blood concentration and thus maintaining activity against the hepatitis C virus. HIV-infected patients 21 years of age and older with chronic hepatitis C infection and a viral load greater than 2000 copies/mL may be eligible for this 2 1/2-year study. Candidates will be screened with blood and urine tests and possibly a liver biopsy, if a recent one is not available. The liver biopsy is done to determine the severity of liver disease. For this test, patients are admitted to the NIH Clinical Center for 1 to 2 days. A sedative is injected into an arm vein, the skin in the area over the biopsy site is numbed with a local anesthetic, and a needle is inserted rapidly into and out of the liver to obtain a small tissue sample. The patient remains in the hospital overnight for monitoring. A chest X-ray, electrocardiogram (EKG) and liver ultrasound are also done. Within 4 weeks of the screening tests, candidates who appear eligible for the study will have a physical examination, medical history and repeat blood tests. Women who can become pregnant will have serial pregnancy tests throughout the study. Patients who meet the study criteria and decide to participate will begin treatment with weekly injections under the skin of peginterferon alfa-2b and take ribavirin pills twice a day by mouth. In addition, patients will continue to take all other medications prescribed by their doctor. Clinic visits will be scheduled as follows: - Days 1, 3, 5, 7, 10 and 21 - Blood will be drawn for safety tests and to measure blood levels of HIV and HCV. - Weeks 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 52, 56 and 64 - Blood and urine tests will be done to determine the side effects of treatment and its effect on the HCV infection. - Week 48 or end of treatment - Treatment will stop after 48 weeks. At this time, or earlier for those who do not complete the 48 weeks, patients will return to the clinic for a routine test.
NCT00027742 ↗ Temozolomide and Interferon Alfa in Treating Patients With Stage III or Stage IV Melanoma Completed National Cancer Institute (NCI) Phase 2 2001-05-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Combining chemotherapy with interferon alfa may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining temozolomide and interferon alfa in treating patients who have stage III or stage IV melanoma.
NCT00027742 ↗ Temozolomide and Interferon Alfa in Treating Patients With Stage III or Stage IV Melanoma Completed Memorial Sloan Kettering Cancer Center Phase 2 2001-05-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Combining chemotherapy with interferon alfa may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining temozolomide and interferon alfa in treating patients who have stage III or stage IV melanoma.
NCT00081770 ↗ Peginterferon Dose Evaluations for Previously Untreated Subjects With Chronic Hepatitis C Infected With Genotype 1 (Study P03471) Completed Merck Sharp & Dohme Corp. Phase 3 2004-03-01 The objective is to compare the safety and efficacy of the following three treatment regimens in previously untreated adult subjects with chronic hepatitis C infected with Genotype 1: (1) PegIntron 1.5 µg/kg/wk in combination with weight based REBETOL (800-1400 mg/day); (2) PegIntron 1µg/kg/wk in combination with weight based REBETOL (800-1400 mg/day); and (3) PEGASYS 180 µg/wk plus COPEGUS 1000-1200 mg/day.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for PEGINTRON

Condition Name

Condition Name for PEGINTRON
Intervention Trials
Hepatitis C, Chronic 49
Hepatitis C 25
Chronic Hepatitis C 8
Hepacivirus 6
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Condition MeSH

Condition MeSH for PEGINTRON
Intervention Trials
Hepatitis 79
Hepatitis C 76
Hepatitis A 69
Hepatitis C, Chronic 66
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Clinical Trial Locations for PEGINTRON

Trials by Country

Trials by Country for PEGINTRON
Location Trials
United States 89
Japan 7
Netherlands 6
Germany 5
France 5
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Trials by US State

Trials by US State for PEGINTRON
Location Trials
Maryland 8
Pennsylvania 7
New York 6
Texas 5
Georgia 5
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Clinical Trial Progress for PEGINTRON

Clinical Trial Phase

Clinical Trial Phase for PEGINTRON
Clinical Trial Phase Trials
Phase 4 16
Phase 3 27
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for PEGINTRON
Clinical Trial Phase Trials
Completed 69
Terminated 8
Unknown status 7
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Clinical Trial Sponsors for PEGINTRON

Sponsor Name

Sponsor Name for PEGINTRON
Sponsor Trials
Merck Sharp & Dohme Corp. 61
Schering-Plough 6
National Institute of Allergy and Infectious Diseases (NIAID) 4
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Sponsor Type

Sponsor Type for PEGINTRON
Sponsor Trials
Industry 86
Other 56
NIH 6
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