Last Updated: June 10, 2026

CLINICAL TRIALS PROFILE FOR JYNNEOS

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All Clinical Trials for JYNNEOS

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Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT06829238 ↗	Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use	RECRUITING	National Institute on Drug Abuse (NIDA)	PHASE4	2025-04-07	This randomized clinical trial (RCT) evaluates whether metformin can reduce systemic inflammation and improve immune function in individuals with a history of injection drug use, with or without HIV. Participants will receive metformin or placebo and undergo immune system assessments, including vaccine response evaluations.
NCT06829238 ↗	Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use	RECRUITING	University of Alabama at Birmingham	PHASE4	2025-04-07	This randomized clinical trial (RCT) evaluates whether metformin can reduce systemic inflammation and improve immune function in individuals with a history of injection drug use, with or without HIV. Participants will receive metformin or placebo and undergo immune system assessments, including vaccine response evaluations.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Start Date	>Summary

Clinical Trial Conditions for JYNNEOS

Condition Name

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Condition Name for JYNNEOS
Intervention	Trials
HIV	1
Immune Dysregulation	1
Injection Drug Use	1
Systemic Inflammation	1
[disabled in preview]	1
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Condition MeSH

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Condition MeSH for JYNNEOS
Intervention	Trials
[disabled in preview]	1
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Clinical Trial Locations for JYNNEOS

Trials by Country

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Trials by Country for JYNNEOS
Location	Trials
United States	1
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Trials by US State

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Trials by US State for JYNNEOS
Location	Trials
Alabama	1
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Clinical Trial Progress for JYNNEOS

Clinical Trial Phase

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Clinical Trial Phase for JYNNEOS
Clinical Trial Phase	Trials
PHASE4	1
[disabled in preview]	0
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Clinical Trial Status

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Clinical Trial Status for JYNNEOS
Clinical Trial Phase	Trials
RECRUITING	1
[disabled in preview]	0
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Clinical Trial Sponsors for JYNNEOS

Sponsor Name

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Sponsor Name for JYNNEOS
Sponsor	Trials
National Institute on Drug Abuse (NIDA)	1
University of Alabama at Birmingham	1
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Sponsor Type

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Sponsor Type for JYNNEOS
Sponsor	Trials
NIH	1
OTHER	1
[disabled in preview]	0
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