A Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Three Preparations of Low-Dose Oral Alpha Interferon in HIV-Infected Patients With CD4+ Counts >= 50 and
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
To evaluate the effects of three preparations of low-dose oral interferon alpha (i.e.,
Alferon LDO, Veldona, and Ferimmune) on HIV symptoms in HIV-infected patients. To evaluate
differences in response to oral interferon alpha according to gender, race/ethnicity, and use
of antiretrovirals.
Previous or ongoing clinical trials to test the efficacy of low-dose oral interferon alpha
have produced different results, and it is not clear whether the differences were due to the
interferon alpha products used or to problems in the study design. Therefore, three
preparations will be compared to evaluate their potential efficacies.
Double-Blind, Randomized, Dose Ranging Study of Alferon LDO (Low Dose Oral Interferon Alfa-n3 (Human Leukocyte Derived)) in HIV+ Subjects
Completed
Interferon Sciences
N/A
1969-12-31
To conduct a double-blind, randomized, dose ranging study of an orally administered low dose
interferon alfa-n3 (IFN-An3) immunomodulator in the treatment of symptomatic HIV+ subjects.
Phase I Study of Alferon N Injection in Persons With Asymptomatic Human Immunodeficiency Virus (HIV) Infection
Completed
Henry M. Jackson Foundation for the Advancement of Military Medicine
Phase 1
1969-12-31
To determine the safety and tolerance of subcutaneous injections of natural interferon alpha
(IFN) in asymptomatic HIV-positive persons and record its effects on the HIV virus in these
individuals.
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