Details for Patent: 6,479,065
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Summary for Patent: 6,479,065
Title: | Process for the preparation of polymer-based sustained release compositions |
Abstract: | The invention relates to a sustained release composition and methods of forming and using said composition for the sustained release of biologically active agent. The sustained release compositions of the invention comprise a biocompatible polymer and a biologically active agent characterized by a porous center and a less porous outer layer wherein the center and outer layer consist of essentially the same materials. The sustained release compositions can be prepared by annealing at least a substantial portion of the exterior surface of a polymer/active agent matrix. The compositions which have been annealed exhibit a decrease in the release of agent over the first 24 hours following administration (i.e., reduced burst) and as a result can show an increase in the duration of sustained release thereby providing increased therapeutic benefits. |
Inventor(s): | Jaworowicz; Warren E. (Boxboro, MA), Wright; James I. (Lexington, MA) |
Assignee: | Alkermes Controlled Therapeutics, Inc. (Cambridge, MA) |
Application Number: | 09/801,272 |
Patent Claim Types: see list of patent claims | Composition; Use; |
Drugs Protected by US Patent 6,479,065
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International Family Members for US Patent 6,479,065
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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Australia | 7812301 | ⤷ Try a Trial | |||
World Intellectual Property Organization (WIPO) | 0213783 | ⤷ Try a Trial | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |