Details for Patent: 9,889,113
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Title: | Method for reversing, preventing, delaying or stabilizing soft tissue calcification |
Abstract: | The present invention provides methods of treating soft tissue calcification in a subject, comprising a step of administering to said subject an effective amount of ferric organic compound, such as ferric citrate. The claimed methods may prevent, reverse, delay or stabilize soft tissue calcification in a subject having chronic kidney disease. Affected soft tissue calcification includes soft tissue calcification in the joint, skin, eye, in cardiovascular system such as heart valve, myocardium, coronary arteries and arteriole, or in internal organs such as kidney and lung. |
Inventor(s): | Chan; Keith (Rockville, MD), Town; Winston (Hong Kong, HK), Chiang; Shou Shan (Taipei, TW) |
Assignee: | Panion & BF Biotech Inc. (TW) |
Filing Date: | Sep 04, 2017 |
Application Number: | 15/694,876 |
Claims: | 1. A method of reversing soft tissue calcification in a subject, comprising administering to said subject an effective amount of ferric citrate having a BET active surface area of at least about 16 m.sup.2/g, wherein soft tissue calcification is reversed. 2. The method of claim 1, wherein the ferric citrate has a BET active surface area of about 16 m.sup.2/g to about 20 m.sup.2/g. 3. The method of claim 1, wherein the soft tissue is selected from soft tissue in a joint, the skin, an eye, a heart valve, the myocardium, a coronary artery, a coronary arteriole, a kidney and a lung. 4. The method of claim 3, wherein the soft tissue is eye tissue. 5. The method of claim 1, wherein the ferric citrate is formulated for oral administration. 6. The method of claim 5, wherein the ferric citrate is formulated as a tablet, a powder, a suspension, an emulsion, a capsule, a lozenge, a granule, a troche, a pill, a liquid, a spirit or a syrup. 7. The method of claim 1, wherein the effective amount of ferric citrate is 2 grams per day. 8. The method of claim 1, wherein the effective amount of ferric citrate is 4 grams per day. 9. The method of claim 1, wherein the effective amount of ferric citrate is 6 grams per day. 10. The method of claim 1, wherein calcification is reversed by up to 40%. 11. The method of claim 1, wherein calcification is reversed by up to 56%. 12. The method of claim 1, wherein calcification is reversed by up to 67%. 13. The method of claim 1, wherein calcification is reversed by up to 100%. |