Details for Patent: 8,703,185
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Title: | Stable pharmaceutical composition and methods of using same |
Abstract: | The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases. |
Inventor(s): | Manku; Mehar (Birmingham, GB), Osterloh; Ian (Kent, GB), Wicker; Pierre (Mystic, CT), Braeckman; Rene (Richboro, PA), Soni; Paresh (Mystic, CT) |
Assignee: | Amarin Pharmaceuticals Ireland Limited (Dublin, IE) |
Filing Date: | May 17, 2013 |
Application Number: | 13/897,217 |
Claims: | 1. A method of treating hypertriglyceridemia in a subject in need thereof comprising, administering to the subject daily a statin and 2500 mg to about 5000 mg of ethyl eicosapentaenoate to reduce fasting triglycerides and LDL-C relative to subjects having hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 2. The method of claim 1 wherein said administering step reduces fasting triglycerides by at least 10% relative to subjects with hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 3. The method of claim 1 wherein said administering step reduces fasting triglycerides by at least 15% relative to subjects with hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 4. The method of claim 1 wherein said administering step reduces fasting triglycerides by at least 20% relative to subjects with hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 5. The method of claim 1 wherein said administering step reduces fasting triglycerides by at least 25% and LDL-C by at least 5% relative to subjects with hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 6. The method of claim 1 wherein said administering step reduces fasting apolipoprotein B relative to subjects with hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 7. The method of claim 1 wherein said administering step reduces fasting apolipoprotein B by at least 5% relative to subjects with hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 8. The method of claim 1 wherein said administering step reduces fasting VLDL-C relative to subjects with hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 9. The method of claim 1 wherein said administering step reduces fasting VLDL-C by at least 15% relative to subjects with hypertriglyceridemia who are receiving a statin without said ethyl eicosapentaenoate. 10. The method of claim 1 wherein the statin is selected from lovastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin, fluvastatin, atorvastatin and simvastatin. 11. The method of claim 1 wherein the ethyl eicosapentaenoate is present in one or more dosage units. 12. The method of claim 11 wherein the dosage units comprise capsules. |