Details for Patent: 7,977,329
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Title: | 5HT.sub.2C receptor modulators |
Abstract: | The present invention relates to novel compounds of Formula (I): ##STR00001## which act as 5HT.sub.2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity. |
Inventor(s): | Smith; Jeffrey (San Diego, CA), Smith; Brian (San Diego, CA) |
Assignee: | Arena Pharmaceuticals, Inc. (San Diego, CA) |
Filing Date: | Nov 14, 2006 |
Application Number: | 11/599,050 |
Claims: | 1. A pharmaceutically acceptable salt of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine. 2. A hydrate of a pharmaceutically acceptable salt of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine. 3. A pharmaceutical composition comprising a hydrate of a pharmaceutically acceptable salt according to claim 2, and a pharmaceutically acceptable carrier or excipient. 4. A pharmaceutical composition comprising a pharmaceutically acceptable salt according to claim 1, and a pharmaceutically acceptable carrier or excipient. 5. A method of decreasing food intake of a mammal comprising administering to said mammal a pharmaceutically effective amount of a pharmaceutically acceptable salt according to claim 1. 6. A method of inducing satiety in a mammal comprising administering to said mammal a pharmaceutically effective amount of a pharmaceutically acceptable salt according to claim 1. 7. A method of controlling weight gain of a mammal comprising administering to said mammal a pharmaceutically effective amount of a pharmaceutically acceptable salt according to claim 1. 8. A method of treatment of obesity comprising administering to a patient in need of such treatment a pharmaceutically effective amount of a pharmaceutically acceptable salt according to claim 1. 9. A method of decreasing food intake of a mammal comprising administering to said mammal a pharmaceutically effective amount of a hydrate of a pharmaceutically acceptable salt according to claim 2. 10. A method of inducing satiety in a mammal comprising administering to said mammal a pharmaceutically effective amount of a hydrate of a pharmaceutically acceptable salt according to claim 2. 11. A method of controlling weight gain of a mammal comprising administering to said mammal a pharmaceutically effective amount of a hydrate of a pharmaceutically acceptable salt according to claim 2. 12. A method of treatment of obesity comprising administering to a patient in need of such treatment a pharmaceutically effective amount of a hydrate of a pharmaceutically acceptable salt according to claim 2. 13. A solvate of a pharmaceutically acceptable salt of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine. 14. A pharmaceutical composition comprising a solvate of a pharmaceutically acceptable salt according to claim 13, and a pharmaceutically acceptable carrier or excipient. 15. A method of decreasing food intake of a mammal comprising administering to said mammal a pharmaceutically effective amount of a solvate of a pharmaceutically acceptable salt according to claim 13. 16. A method of inducing satiety in a mammal comprising administering to said mammal a pharmaceutically effective amount of a solvate of a pharmaceutically acceptable salt according to claim 13. 17. A method of controlling weight gain of a mammal comprising administering to said mammal a pharmaceutically effective amount of a solvate of a pharmaceutically acceptable salt according to claim 13. 18. A method of treatment of obesity comprising administering to a patient in need of such treatment a pharmaceutically effective amount of a solvate of a pharmaceutically acceptable salt according to claim 13. |