Details for Patent: 7,879,993
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Title: | Platelet derived growth factor (PDGF) nucleic acid ligand complexes |
Abstract: | This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF Nucleic Acid Ligand by SELEX methodology and associating the PDGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more PDGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a PDGF Nucleic Acid Ligand or Complex and methods for making the same. |
Inventor(s): | Janjic; Nebojsa (Boulder, CO), Gold; Larry (Boulder, CO) |
Assignee: | Gilead Sciences, Inc. (Foster City, CA) |
Filing Date: | Aug 01, 2007 |
Application Number: | 11/832,411 |
Claims: | 1. A nucleic acid ligand to PDGF comprising the sequence: TABLE-US-00010 (SEQ ID NO:146) CAGGC A G-N-CGTAGAGCA A-N-TGAT G[3'T] wherein A,C,G,T=deoxy-A,C,G,T; A,C,G,U=2'-OMe-A,C,G,T; C,U=2'-fluoro-C,U; N is from hexaethyleneglycol phosphoramidite; and [3'T]=inverted (3'-3') T. |