Details for Patent: 6,855,830
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Title: | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
Abstract: | Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis. |
Inventor(s): | Hirth; Bradford H. (Littleton, MA), Siegel; Craig (Woburn, MA) |
Assignee: | Genzyme Corporation (Cambridge, MA) |
Filing Date: | Jul 16, 2002 |
Application Number: | 10/197,227 |
Claims: | 1. A compound represented by the following structural formula: ##STR32## the enantiomer of the compound, a salt of the compound, or a salt of the enantiomer, wherein: R.sub.4 is H.sub.2 or O; and R.sub.6 is represented by the following structural formula: ##STR33## wherein phenyl ring A is substituted or unsubstituted; or when R.sub.4 is H.sub.2, R.sub.6 can further be --H. 2. The compound of claim 1 wherein phenyl ring A is unsubstituted. |