Details for Patent: 5,840,891
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Title: | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative |
Abstract: | The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption. |
Inventor(s): | Nestor, Jr.; John J. (Louisville, KY), Maag; Hans (Menlo Park, CA) |
Assignee: | Syntex (U.S.A.) Inc. (Palo Alto, CA) |
Filing Date: | Mar 04, 1997 |
Application Number: | 08/812,990 |
Claims: | 1. A compound of the formula ##STR15## where P.sup.1 is a hydroxy-protecting group; P.sup.2 is an amino-protecting group; and the asterisk denotes an asymmetric carbon atom. 2. A compound of the formula ##STR16## where P.sup.1 is a hydroxy-protecting group removable under acidic conditions or by hydrogenolysis; P.sup.2 is an amino-protecting group; and the asterisk denotes an asymmetric carbon atom. 3. A compound of claim 1 where P.sup.1 is benzyl, trityl, allyl, tetrahydropyranyl, silyl, or trialkylsilyl. 4. A compound of claim 1 wherein P.sup.2 is C.sub.1-4 alkanoyl, trityl, trifluoroacetyl, N-(9-fluorenylmethoxycarbonyl), allyloxycarbonyl, N-benzyloxycarbonyl, t-butyloxycarbonyl, or phthalyl. 5. A compound of claim 3 where P.sup.2 is C.sub.1-4 alkanoyl, trityl, trifluoroacetyl, N-(9-fluorenylmethoxycarbonyl), allyloxycarbonyl, N-benzyloxycarbonyl, t-butyloxycarbonyl, or phthalyl. 6. The compound of claim 5 where P.sup.1 is benzyl and P.sup.2 is N-benzyloxycarbonyl. |