Details for Patent: 5,597,898
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Title: | NF-.kappa.B activation regulatory protein, I.kappa.B-.beta. |
Abstract: | The present invention provides a novel polypeptide, I.kappa.B-.beta., which binds to and affects NF-.kappa.B gene activation. Also provided is the nucleotide sequence encoding I.kappa.B-.beta. and methods of identifying compositions which affect I.kappa.B-.beta..backslash.NF-.kappa.B complexes. Methods of treatment of disorders associated with NF-.kappa.B induced gene activation are also described herein. |
Inventor(s): | Ghosh; Sankar (Madison, CT) |
Assignee: | Yale University (New Haven, CT) |
Filing Date: | Feb 15, 1995 |
Application Number: | 08/388,756 |
Claims: | 1. An isolated I.kappa.B-.beta. polypeptide having the amino acid sequence of SEQ ID NO: 2. |