Details for Patent: 5,580,984
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Title: | Retroviral protease inhibiting compounds |
Abstract: | A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed. |
Inventor(s): | Kempf; Dale J. (Libertyville, IL), Norbeck; Daniel W. (Crystal Lake, IL), Sham; Hing L. (Gurnee, IL), Zhao; Chen (Gurnee, IL), Sowin; Thomas J. (Grayslake, IL), Reno; Daniel S. (Kenosha, WI), Haight; Anthony R. (Park City, IL) |
Assignee: | Abbott Laboratories (Abbott Park, IL) |
Filing Date: | Mar 28, 1995 |
Application Number: | 08/412,253 |
Claims: | 1. A compound of the formula: ##STR18## wherein R.sub.4 and R.sub.4a are independently selected from phenyl, thiazolyl and oxazolyl wherein the phenyl, thiazolyl or oxazolyl ring is unsubstituted or substituted with a substituent selected from (i) halo, (ii) C.sub.1 -to-C.sub.6 -loweralkyl, (iii) hydroxy, (iv) C.sub.1 -to-C.sub.6 -alkoxy and (v) C.sub.1 -to-C.sub.6 -thioalkoxy; and R* is phenyl, halo-substituted phenyl, dihalo-substituted phenyl, C.sub.1 -to-C.sub.6 -alkoxy-substituted phenyl, C.sub.1 -to-C.sub.6 -loweralkyl-substituted phenyl, bis-trifluormethyl-substituted phenyl or naphthyl or C.sub.1 -to-C.sub.6 -loweralkyl; or an acid addition salt thereof. 2. The compound of claim 1 wherein R.sub.4 and R.sub.4a are phenyl and R* is phenyl. 3. A compound of the formula: ##STR19## wherein R.sub.4 and R.sub.4a are independently selected from phenyl, thiazolyl and oxazolyl wherein the phenyl, thiazolyl or oxazolyl ring is unsubstituted or substituted with a substituent selected from (i) halo, (ii) C.sub.1 -to-C.sub.6 -loweralkyl, (iii) hydroxy, (iv) C.sub.1 -to-C.sub.6 -alkoxy and (v) C.sub.1 -to-C.sub.6 -thioalkoxy; and R* is phenyl, halo-substituted phenyl, dihalo-substituted phenyl, C.sub.1 -to-C.sub.6 -alkoxy-substituted phenyl, C.sub.1 -to-C.sub.6 -loweralkyl-substituted phenyl, bis-trifluormethyl-substituted phenyl or naphthyl or C.sub.1 -to-C.sub.6 -loweralkyl; or an acid addition salt thereof. 4. The compound of claim 3 wherein R.sub.4 and R.sub.4a are phenyl and R* is phenyl. 5. A compound selected from the group consisting of: (4S,6S, 1'S)-6-(1-Amino-2-phenylethyl)-4-benzyl-2-phenyl-3-aza-2-bora-1-oxacyclohe xane; and (4S,6S,1'S)-6-(1-Amino-2-phenylethyl)-2-phenyl-4-((5-thiazolyl)methyl)-3-az a-2-bora-1-oxacyclohexane; or an acid addition salt thereof. |