Details for Patent: 5,539,116
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Title: | Method and compositions for the synthesis of BCH-189 and related compounds |
Abstract: | The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the steochemistry at the nucleoside 4' position can be controlled to produce enantiomerically-enriched .beta.-BCH-189 and its analogs. |
Inventor(s): | Liotta; Dennis C. (Stone Mountain, GA), Choi; Woo-Baeg (Atlanta, GA) |
Assignee: | Emory University (Atlanta, GA) |
Filing Date: | Feb 10, 1993 |
Application Number: | 08/015,992 |
Claims: | 1. The (-)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine (BCH-189). 2. The (-)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine (BCH-189), in substantially pure form. 3. The (-)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine substantially free of the (+)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine. 4. A composition consisting essentially of the (-)-enantiomer of the .beta.-isomer of 2',3'-dideoxy-3'-thia-cytidine. 5. .beta.-BCH-189 substantially in the form of one optical isomer. 6. A composition consisting essentially of one optical isomer of .beta.-BCH-189. 7. Enantiomerically enriched .beta.-BCH-189. |