Claims for Patent: 9,925,268

Summary for Patent: 9,925,268

Title:	Drug-containing implants and methods of use thereof
Abstract:	The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
Inventor(s):	Siegel Steven, Winey Karen
Assignee:	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Application Number:	US15627349
Patent Claims:	2. The implant of claim 1 , wherein said drug is present in an amount of about 30-60% (w/w).3. The implant of claim 1 , wherein said drug is present in an amount of about 60% (w/w).4. The implant of claim 1 , wherein said drug is present in an amount of about 56% (w/w).5. The implant of claim 1 , wherein said drug is present in an amount of about 54% (w/w).6. The implant of claim 1 , wherein said drug is present in an amount of about 52% (w/w).7. The implant of claim 1 , wherein said drug is present in an amount of about 50% (w/w).8. The implant of claim 1 , wherein said drug is present in an amount of about 40% (w/w).9. The implant of claim 1 , wherein said drug is present in an amount of about 30% (w/w).10. The implant of claim 1 , wherein said drug is present in an amount of about 28% (w/w).11. The implant of claim 1 , wherein said drug is present in an amount of about 20% (w/w).12. The implant of claim 1 , wherein said drug is present in an amount of about 15% (w/w).13. The implant of claim 1 , wherein said drug is present in an amount of about 10% (w/w).14. The implant of claim 1 , wherein said polymer is a biodegradable polymer.15. The implant of claim 1 , wherein said polymer is PLGA polymer.16. The implant of claim 1 , wherein said PLA:PGA molar ratio is 75:25.17. The implant of claim 1 , wherein said PLA:PGA molar ratio is 80:20.18. The implant of claim 1 , wherein said PLA:PGA molar ratio is 85:15.19. The implant of claim 1 , wherein said polymer is PLA.20. The implant of claim 1 , wherein said polymer is present in an amount of about 40-90% (w/w).21. The implant of claim 20 , wherein said polymer is present in an amount of about 40-70% (w/w).22. The implant of claim 20 , wherein said polymer is present in an amount of about 70-90% (w/w).23. The implant of claim 1 , wherein said polymer is present in an amount of about 30% (w/w).24. The implant of claim 1 , wherein said polymer is present in an amount of about 35% (w/w).25. The implant of claim 1 , wherein said polymer is present in an amount of about 40% (w/w).26. The implant of claim 1 , wherein said polymer is present in an amount of about 50% (w/w).27. The implant of claim 1 , wherein said implant exhibits an inherent viscosity ranging from about 0.2 dl/g to about 0.9 dl/g.28. The implant of claim 1 , wherein said implant is a subcutaneous implant.29. The implant of claim 1 , wherein said implant extends the release duration of said therapeutic drug upon subcutaneous administration in said subject maintaining a therapeutic level of the therapeutic drug for a period of 1 to 6 months.