Claims for Patent: 8,461,333

Summary for Patent: 8,461,333

Title:	Salts of prodrugs of piperazine and substituted piperidine antiviral agents
Abstract:	This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. ##STR00001## wherein: X is C or N with the proviso that when X is N, R.sup.1 does not exist; W is C or N with the proviso that when W is N, R.sup.2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of ##STR00002## Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. ##STR00003## wherein: L and M are independently selected from the group consisting of C.sub.1-C.sub.6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
Inventor(s):	Ueda; Yasutsugu (Clinton, CT), Connolly; Timothy P. (Portland, CT), Kadow; John F. (Wallingford, CT), Meanwell; Nicholas A. (East Hampton, CT), Wang; Tao (Farmington, CT), Chen; Chung-Pin H. (Madison, CT), Yeung; Kap-Sun (Madison, CT), Zhang; Zhongxing (Madison, CT), Leahy; David Kenneth (Hightstown, NJ), Pack; Shawn K. (Plainsboro, NJ), Soundararajan; Nachimuthu (Kendall Park, NJ), Sirard; Pierre (St. Jean sur Richelieu, CA), Levesque; Kathia (Ste-Catherine, CA), Thoraval; Dominique (Candiac, CA)
Assignee:	Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:	13/429,838
Patent Claims:	1. A pharmaceutically acceptable salt of the compound 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphon- ooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, having the following structure: ##STR00105## 2. The pharmaceutically acceptable salt of claim 1, wherein said salt is a mono tromethamine (TRIS) salt.