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Last Updated: April 30, 2024

Claims for Patent: 8,354,430

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Summary for Patent: 8,354,430

Title:	Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl) propoxy]propyl]-piperidine
Abstract:	A method is provided for the treatment of sleep apnea and other conditions wherein an effective amount of crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride of formula (I): ##STR00001## optionally comprising water up to 6%, and having an X-ray diffractogram that comprises characteristic peaks (2.theta.) at 11.2.degree., 19.9.degree., 20.7.degree. and 34.1.degree..+-.0.2.degree. is administered to a patient in need thereof.
Inventor(s):	Raga; Manuel (Barcelona, ES), Sallares; Juan (Barcelona, ES), Guerrero; Marta (Barcelona, ES), Guglietta; Antonio (Molins De Rei, ES), Arrang; Jean-Michel (Dourdan, ES), Schwartz; Jean-Charles (Paris, FR), Stark; Holger (Homburg, DE), Schunack; Walter (Berlin, DE), Ligneau; Xavier (Saint Gregoire, FR), Lecomte; Jeanne-Marie (Paris, FR), Ganellin; Charon (Thame, GB)
Assignee:	Bioprojet (Paris, FR)
Application Number:	13/491,229
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,354,430
Patent Claims:	1. A method for the treatment of sleep apnea, comprising administering crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride of formula (I): ##STR00003## optionally comprising water up to 6%, and having an X-ray diffractogram that comprises characteristic peaks (2.theta.) at 11.2.degree., 19.9.degree., 20.7.degree. and 34.1.degree..+-.0.2.degree.. 2. The method of claim 1 wherein the crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride according to claim 1 has an X-ray diffractogram that comprises characteristic peaks (2.theta.) at 11.2.degree., 15.4.degree., 16.3.degree., 16.9.degree., 17.8.degree., 19.9.degree., 20.7.degree., 21.0.degree., 21.8.degree., 22.6.degree., 24.5.degree., 24.6.degree., 25.0.degree., 25.5.degree., 26.3.degree., 28.3.degree., 30.3.degree., 34.1.degree., 35.8.degree., 40.0.degree., 46.0.degree..+-.0.2.degree.. 3. A method for the treatment of diurnal somnolence comprising administering crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride of formula (I): ##STR00004## comprising water up to 6%, and having an X-ray diffractogram that comprises characteristic peaks (2.theta.) at 11.2.degree., 19.9.degree., 20.7.degree. and 34.1.degree..+-.0.2.degree.. 4. The method of claim 3 wherein the crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride according to claim 1 has an X-ray diffractogram that comprises characteristic peaks (2.theta.) at 11.2.degree., 15.4.degree., 16.3.degree., 16.9.degree., 17.8.degree., 19.9.degree., 20.7.degree., 21.0.degree., 21.8.degree., 22.6.degree., 24.5.degree., 24.6.degree., 25.0.degree., 25.5.degree., 26.3.degree., 28.3.degree., 30.3.degree., 34.1.degree., 35.8.degree., 40.0.degree., 46.0.degree..+-.0.2.degree.. 5. A method for the treatment of psychotropic disorders comprising administering crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride of formula (I): ##STR00005## optionally comprising water up to 6%, and having an X-ray diffractogram that comprises characteristic peaks (2.theta.) at 11.2.degree., 19.9.degree., 20.7.degree. and 34.1.degree..+-.0.2.degree.. 6. The method of claim 5 wherein the crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride according to claim 1 has an X-ray diffractogram that comprises characteristic peaks (2.theta.) at 11.2.degree., 15.4.degree., 16.3.degree., 16.9.degree., 17.8.degree., 19.9.degree., 20.7.degree., 21.0.degree., 21.8.degree., 22.6.degree., 24.5.degree., 24.6.degree., 25.0.degree., 25.5.degree., 26.3.degree., 28.3.degree., 30.3.degree., 34.1.degree., 35.8.degree., 40.0.degree., 46.0.degree..+-.0.2.degree..

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