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Last Updated: May 18, 2024

Claims for Patent: 8,221,778


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Summary for Patent: 8,221,778
Title:Drug-containing implants and methods of use thereof
Abstract:The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
Inventor(s):Siegel Steven, Winey Karen
Assignee:The Trustees of the University of Pennsylvania
Application Number:US11183232
Patent Claims: 2. The implant of claim 1 , wherein said implant is removable.3. The implant of claim 1 , wherein said therapeutic drug further comprises haloperidol.4. The implant of claim 1 , wherein said implant has a surface area to volume ratio between 1 and 4 (millimeters [mm])/mm.5. The implant of claim 1 , wherein said implant has a length between 3-45 millimeters.6. The implant of claim 1 , wherein said implant has a diameter between 2-4 millimeters.17. A method for releasing a therapeutic drug at a substantially linear rate for a period of at least 1 month into a body tissue of a subject claim 1 , comprising administering to said subject the implant of claim 1 , thereby releasing a therapeutic drug at a substantially linear rate for a period of at least month into a body tissue of a subject.8. A method for treating schizophrenia in a human claim 1 , comprising administering the implant of to said human claim 1 , thereby treating schizophrenia in said human.9. A method for treating bipolar disorder claim 1 , agitation claim 1 , impulse control claim 1 , dementia claim 1 , depression or delirium in a human claim 1 , comprising administering the implant of to said human claim 1 , thereby treating bipolar disorder claim 1 , agitation claim 1 , impulse control claim 1 , dementia claim 1 , depression or delirium in said human.

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