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Last Updated: May 17, 2024

Claims for Patent: 8,153,661

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Summary for Patent: 8,153,661

Title:	Controlled delivery system
Abstract:	The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.
Inventor(s):	Verity; A. Neil (Sunnyvale, CA)
Assignee:	Durect Corporation (Cupertino, CA)
Application Number:	11/888,648
Patent Claims:	1. A method for providing sustained local anesthesia by administering to a subject a composition comprising: about 66% by weight sucrose acetate isobutyrate (SAIB) liquid carrier material relative to the total weight of the composition; about 12% by weight bupivacaine relative to the total weight of the composition; and about 22% by weight benzyl alcohol (BA) relative to the total weight of the composition, wherein after administration the bupivacaine is released from said composition for a period of at least 24 hours in an amount sufficient to provide sustained local anesthesia. 2. The method of claim 1, wherein said composition is administered to a surgical wound. 3. The method of claim 2, wherein said composition is administered into and/or adjacent to the surgical wound. 4. The method of claim 2, wherein said composition is administered by pouring. 5. The method of claim 1, wherein said subject is a human patient undergoing surgical inguinal hernia repair or an appendectomy. 6. The method of claim 1, wherein said composition is used to treat post-operative pain. 7. The method of claim 1, wherein the bupivacaine is present in the composition in free base form. 8. The method of claim 1, wherein administration of said composition provides sustained local anesthesia for a period of at least about 48 hours. 9. The method of claim 1, wherein administration of said composition provides sustained local anesthesia for a period of at least about 72 hours.

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