Claims for Patent: 11,357,738

Summary for Patent: 11,357,738

Title:	Semifluorinated compounds and their compositions
Abstract:	The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.
Inventor(s):	Scherer Dieter, Grillenberger Ralf, Löscher Frank, Voss Hartmut
Assignee:	NOVALIQ GMBH
Application Number:	US16874617
Patent Claims:	1. A composition consisting essentially of CF(CF)(CH)CHand CF—(CF)—CH(CH)—(CH)—CH , wherein the CF(CF)(CH)CHis present in an amount of at least 90 wt. % and the CF—(CF)—CH(CH)—(CH)—CHis present in an amount of up to 10 wt. %.2. The composition according to claim 1 , wherein the CF(CF)(CH)CHis present in an amount of at least 95 wt. % and the CF—(CF)—CH(CH)—(CH)—CHis present in an amount of up to 5 wt. %.3. The composition according to claim 1 , wherein the CF(CF)(CH)CHis present in an amount of at least 97 wt. % and the CF—(CF)—CH(CH)—(CH)—CHis present in an amount of up to 3 wt. %.4. The composition according to claim 1 , wherein the composition consists essentially of CF(CF)(CH)CHand up to 3 wt. % CF—(CF)—CH(CH)—(CH)—CH.5. The composition according to claim 1 , being formulated as a clear liquid solution.6. The composition of claim 1 , being substantially free of:(a) a polymer,(b) a perfluorinated compound, and/or(c) a dissolved pharmacologically active ingredient.7. The composition of claim 1 , having a dynamic viscosity of not more than 10 mPa·s.8. The composition according to claim 1 , wherein the composition consists of CF(CF)(CH)CHand CF—(CF)—CH(CH)—(CH)—CH claim 1 , wherein the CF(CF)(CH)CHis present in an amount of at least 90 wt. % and the CF—(CF)—CH(CH)—(CH)—CHis present in an amount of up to 10 wt. %.9. The composition according to claim 8 , wherein the CF(CF)(CH)CHis present in an amount of at least 95 wt. % and the CF—(CF)—CH(CH)—(CH)—CHis present in an amount of up to 5 wt. %.10. The composition according to claim 8 , wherein the CF(CF)(CH)CHis present in an amount of at least 97 wt. % and the CF—(CF)—CH(CH)—(CH)—CHis present in an amount of up to 3 wt. %.11. The composition according to claim 8 , wherein the composition consists of CF(CF)(CH)CHand up to 3 wt. % CF—(CF)—CH(CH)—(CH)—CH.12. The composition according to claim 1 , wherein the composition consists of CF(CF)(CH)CHand about 1 wt. % of CF—(CF)—CH(CH)—(CH)—CH.13. The composition according to claim 1 , wherein the composition consists of about 97 wt claim 1 ,% of CF(CF)(CH)CHand about 3 wt. % of CF—(CF)—CH(CH)—(CH)—CH.14. The composition according to claim 5 , having a refractive index from about 1.30 to about 1.35 at 20° C. claim 5 , as determined by refractometer.15. A kit comprising a composition according to and a container for holding the composition claim 1 , wherein said container comprises a dispensing means adapted for topical administration of the composition to a lacrimal sac claim 1 , into a lower eyelid claim 1 , to an eye surface claim 1 , or to an ophthalmic tissue.16. The kit of claim 15 , wherein the dispensing means comprises a dropper of dimensions such as to dispense droplets having a volume of 8 to 15 μL.17. The kit according to claim 15 , wherein the dispensing means comprises a dropper of dimensions such as to dispense droplets having a volume of about 8 to 12 μL.18. The kit according to claim 15 , wherein the dispensing means comprises a dropper of dimensions such as to dispense droplets having a volume of about 10 μL.