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Last Updated: May 3, 2024

Claims for Patent: 10,765,749

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Summary for Patent: 10,765,749

Title:	Non-aqueous patch
Abstract:	Non-aqueous patches comprising lidocaine, which is not dissolved and is present in a crystalline state, have poor permeability to the skin. Therefore, non-aqueous patches have a high concentration of lidocaine. It is pointed out that lidocaine has an adverse effect on the heart. Prolonged use of a high concentration of lidocaine causes side effects, such as shock, rubor, and irritating sensation. External preparations comprising more than 5 mass % of lidocaine are designated as powerful drugs, and cannot be used as household (nonprescription) medicine. Provided is a non-aqueous patch that is effective to relieve muscle pain, the non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent composed of an organic acid and a polyalcohol, which are contained in a base.
Inventor(s):	Mori; Tatsuya (Saga, JP), Saida; Naoyuki (Saga, JP)
Assignee:	ITOCHU CHEMICAL FRONTIER Corporation (Tokyo, JP) OISHI KOSEIDO CO., LTD. (Saga, JP)
Application Number:	15/891,915
Patent Claims:	1. A non-aqueous patch comprising a plaster comprising lidocaine, a dissolving agent, and an elastomer, wherein, the plaster comprises 0.5 to 7 mass % lidocaine and 1.435 to 9.1 mass% dissolving agent, the dissolving agent comprises dipropylene glycol and isostearic acid, and the isostearic acid is present in the plaster in an amount of 1.4 to 2.1 mass%. 2. The non-aqueous patch according to claim 1, wherein the elastomer consists of polyisobutylene and styrene isoprene rubber. 3. The non-aqueous patch according to claim 1, wherein the plaster comprises 10 mass % to 40 mass % of the elastomer. 4. The non-aqueous patch according to claim 1, wherein the plaster comprises 20 mass % to 40 mass % of the elastomer. 5. The non-aqueous patch according to claim 1, wherein the plaster further comprises a terpene resin. 6. The non-aqueous patch of claim 1, wherein after application to a human for 12 hours, the amount of lidocaine remaining in the non-aqueous patch is 80% or less than the amount prior to application.

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