Claims for Patent: 10,765,640

Summary for Patent: 10,765,640

Title:	Non-aqueous patch
Abstract:	[Problem] If lidocaine is composed of non-aqueous patch, the adhesive power of the preparation tends to get lower, as the composition amount of lidocaine is higher. It is popular to solve lidocaine in dissolving agent in order to compose lidocaine in patch and release effective amount into skin. However, if the amount of dissolving agent gets higher, the adhesive power gets extremely lower, so that an long-time attachment is difficult. [Solution] A non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent which are contained in a base of plaster, the plaster being hold by a support, of which strength of 50% stretched to longitudinal direction is less than 2,000 g/50 mm and of biaxially-oriented stretch cloth.
Inventor(s):	Mori; Tatsuya (Saga, JP), Saida; Naoyuki (Saga, JP)
Assignee:	ITOCHU CHEMICAL FRONTIER Corporation (Tokyo, JP) OISHI KOSEIDO CO., LTD. (Saga, JP)
Application Number:	14/346,794
Patent Claims:	1. A non-aqueous patch comprising 0.5 to 7 mass % lidocaine, and a dissolving agent comprising an organic acid and a polyalcohol, wherein the lidocaine and the dissolving agent are in a plaster, the plaster being held by a support, wherein the support has a stretch strength of less than 2,000g/50 mm when the support is stretched by 50% longitudinal extension; and wherein the support comprises a biaxially-oriented stretch cloth, wherein the organic acid is isostearic acid, which is present in the plaster in an amount of 0.9 mass % to 2.5 mass %, and the polyalcohol is dipropylene glycol, which is present in the plaster in an amount of 0.2 mass % to 1.5 mass % dipropylene glycol. 2. The non-aqueous patch of claim 1, wherein the adhesive power of the patch is from 0.4N/width 25 mm to 5N/width 25 mm. 3. The non-aqueous patch of claim 1, wherein the release ratio of lidocaine from the plaster is more than 6%, after 12 hours attachment to the skin. 4. The non-aqueous patch of claim 1, wherein the amount of lidocaine is 0.1 to 1 mg/cm.sup.2 of the plaster. 5. The non-aqueous patch of claim 1, wherein the plaster consists of lidocaine, isostearic acid and dipropylene glycol, an elastomer, a terpene resin, butylated hydroxytoluene, liquid paraffin and light anhydrous silicic acid. 6. The non-aqueous patch of claim 5, wherein the elastomer consists of a combination of styrene isoprene and polyisobutylene. 7. The non-aqueous patch of claim 1, wherein the lidocaine is dissolved in the dissolving agent. 8. The non-aqueous patch of claim 5, wherein the lidocaine, the polyalcohol and the organic acid are combined prior to the addition of the elastomer, the terpene resin, the butylated hydroxytoluene, the liquid paraffin and the light anhydrous silicic acid.