Claims for Patent: 10,548,943

Summary for Patent: 10,548,943

Title:	Method of treating low blood pressure
Abstract:	A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
Inventor(s):	Chawla; Lakhmir S. (McLean, VA)
Assignee:	The George Washington University a Congressionally Chartered Not-for-Profit Corporation (Washington, DC)
Application Number:	16/439,881
Patent Claims:	1. A method of increasing blood pressure in a human subject having septic shock and in need of said increasing, comprising administering Angiotensin 11 to the human subject at an initial rate of about 20 ng/kg/min. 2. The method of claim 1, further comprising titrating the rate up to about 30 ng/kg/min. 3. The method of claim 1, further comprising titrating the rate up to about 40 ng/kg/min. 4. The method of claim 1, wherein the rate is titrated up one or more times by about 10 ng/kg/min. 5. The method of claim 1, wherein the Angiotensin II is administered to the human subject over a period of about 0.25 hours to about 120 hours. 6. The method of claim 5, wherein the Angiotensin II is administered to the human subject over a period of about 1 hour to about 7 hours. 7. The method of claim 1, wherein the rate of administration of Angiotensin II is titrated to achieve a mean arterial pressure of about 65 mmHg. 8. The method of claim 1, wherein the rate of administration of Angiotensin II is titrated to achieve a mean arterial pressure of 65 mmHg. 9. The method of claim 7, wherein the mean arterial pressure is maintained at about 65 mmHg for about 0.25 hours to about 120 hours. 10. The method of claim 9, wherein the mean arterial pressure is maintained at about 65 mmHg for about 1 hour to about 7 hours. 11. The method of claim 1, wherein the human subject is undergoing treatment with one or more vasopressors. 12. The method of claim 11, wherein the one or more vasopressors is selected from the group consisting of norepinephrine, vasopressin, epinephrine, and dopamine. 13. The method of claim 12, wherein the one or more vasopressors is norepinephrine. 14. The method of claim 12, wherein the one or more vasopressors is vasopressin. 15. The method of claim 11, further comprising titrating the rate up to about 30 ng/kg/min. 16. The method of claim 11, further comprising titrating the rate up to about 40 ng/kg/min. 17. The method of claim 11, wherein the rate is titrated up one or more times by about 10 ng/kg/min. 18. The method of claim 11, wherein the Angiotensin II is administered to the human subject over a period of about 0.25 hours to about 120 hours. 19. The method of claim 18, wherein the Angiotensin II is administered to the human subject over a period of about 1 hour to about 7 hours. 20. The method of claim 11, wherein the rate of administration of Angiotensin II is titrated to achieve a mean arterial pressure of about 65 mmHg. 21. The method of claim 11, wherein the rate of administration of Angiotensin II is titrated to achieve a mean arterial pressure of 65 mmHg. 22. The method of claim 20, wherein the mean arterial pressure is maintained at about 65 mmHg for about 0.25 hours to about 120 hours. 23. The method of claim 22, wherein the mean arterial pressure is maintained at about 65 mmHg for about 1 hour to about 7 hours. 24. A method of increasing blood pressure in a human subject having septic shock and in need of said increasing, comprising administering Angiotensin 11 to the human subject at a rate of from about 20 ng/kg/min to about 40 ng/kg/min. 25. The method of claim 24, wherein the Angiotensin II is administered at a rate of about 30 ng/kg/min. 26. The method of claim 24, wherein the Angiotensin II is administered at a rate of about 40 ng/kg/min.