Claims for Patent: 10,285,993

Summary for Patent: 10,285,993

Title:	Crystalline form of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyri- midin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
Abstract:	A novel crystalline form of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrim- idin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutical compositions containing said crystalline form and the use of said crystalline form in the treatment of pain, cancer, inflammation, neurodegenerative disease or Trypanosoma cruzi infection are disclosed. In some embodiments, the novel crystalline form comprises a stable polymorph of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrim- idin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate. The present invention is further directed to a process for the preparation of the novel crystalline form.
Inventor(s):	Arrigo; Alisha B. (Boulder, CO), Juengst; Derrick (Boulder, CO), Shah; Khalid (South San Francisco, CA)
Assignee:	Array BioPharma Inc. (Boulder, CO)
Application Number:	15/706,062
Patent Claims:	1. A method of treating a cancer mediated by a Trk kinase in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a crystalline form (I-HS) having the formula: ##STR00007## wherein the crystalline form is characterized by having XRPD diffraction peaks (2.theta. degrees) at 18.4.+-.0.2, 20.7.+-.0.2, 23.1.+-.0.2, and 24.0.+-.0.2. 2. The method of claim 1, wherein the crystalline form is characterized by having XRPD diffraction peaks (2.theta. degrees) at 10.7.+-.0.2, 18.4.+-.0.2, 20.7.+-.0.2, 23.1.+-.0.2, and 24.0.+-.0.2. 3. The method of claim 1, wherein the crystalline form is characterized by having XRPD diffraction peaks (2.theta. degrees) at 10.7.+-.0.2, 18.4.+-.0.2, 19.2.+-.0.2, 20.2.+-.0.2, 20.7.+-.0.2, 21.5.+-.0.2, 23.1.+-.0.2, and 24.0.+-.0.2. 4. The method of claim 1, wherein the crystalline form is characterized by having XRPD diffraction peaks (2.theta. degrees) at 10.7.+-.0.2, 15.3.+-.0.2, 16.5.+-.0.2, 18.4.+-.0.2, 19.2.+-.0.2, 19.9.+-.0.2, 20.2.+-.0.2, 20.7.+-.0.2, 21.5.+-.0.2, 22.1.+-.0.2, 23.1.+-.0.2, 24.0.+-.0.2, 24.4.+-.0.2, 25.6.+-.0.2, 26.5.+-.0.2, 27.6.+-.0.2, 28.2.+-.0.2, 28.7.+-.0.2, 30.8.+-.0.2, and 38.5.+-.0.2. 5. The method of claim 1, wherein the crystalline form exhibits an onset to maximum of about 193.degree. C. to about 205.degree. C., as measured by differential scanning calorimetry. 6. The method of claim 1, wherein the crystalline form exhibits a heat of melting of about 2.415 mW, as measured by differential scanning calorimetry. 7. The method of claim 1, wherein the cancer is mediated by TrkA. 8. The method of claim 1, wherein the cancer is mediated by TrkB. 9. The method of claim 1, wherein the cancer is mediated by TrkA and TrkB.