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Last Updated: May 17, 2024

Claims for Patent: 10,238,668

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Summary for Patent: 10,238,668

Title:	Co-crystals of tramadol and coxibis
Abstract:	The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
Inventor(s):	Plata Salaman; Carlos Ramon (Barcelona, ES), Tesson; Nicolas (L'Hospitalet de Llobregat, ES)
Assignee:	LABORATORIOS DEL DR. ESTEVE, S.A. (Barcelona, ES)
Application Number:	15/207,694
Patent Claims:	1. A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it shows a Powder X-Ray Diffraction pattern with peaks [2.theta.] at 14.1, 16.8, 19.0 and 22.7[.degree.], with the 2.theta. values being obtained using copper radiation (CuK.alpha.1 1.54060.ANG.). 2. The co-crystal of claim 1, characterized in that it shows additional peaks at [2.theta.] 7.1, 19.9 and 20.5[.degree.]. 3. The co-crystal of claim 2, characterized in that it shows additional peaks [2.theta.] at 13.6, 13.9, 17.5, 18.0, 19.5, 21.2, 21.3, 21.8, 22.6, 23.6, 24.1, 24.4 and 26.1 [.degree.]. 4. A method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in claim 1. 5. A method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in claim 2. 6. A method of treatment of pain, comprising administering to a patient in need thereof an effective amount of a co-crystal as defined in claim 3.

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