Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation
Completed
Dompé Farmaceutici S.p.A
Phase 2
The chemokine CXCL8 plays a key role in the recruitment and activation of polymorphonuclear
neutrophils in post-ischemia reperfusion injury after solid organ transplantation. Reparixin
is a novel, specific inhibitor of CXCL8. This study is configured to explore the safety and
efficacy of reparixin in preventing the delayed graft function (DGF) after kidney
transplantation.
Inhibition of CXCL8 activity might represent a relevant therapeutic target to prevent injury
occurring after pancreatic islet transplantation. Reparixin is a novel and specific inhibitor
of CXCL8. This study is designed to explore the efficacy of reparixin in preventing graft
dysfunction after islet transplantation in type 1 diabetes patients (T1D).
Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation
Completed
Dompé Farmaceutici S.p.A
Phase 3
The objective of this clinical trial was:
- to assess whether Reparixin leads to improved transplant outcome as measured by glycaemic
control following intra-hepatic infusion of pancreatic islets in patients with Type 1
diabetes (T1D). The safety of Reparixin in the specific clinical setting was also evaluated.
Background: The chemokine CXCL8 plays a key role in the recruitment and activation of
polymorphonuclear neutrophils in post-ischemia reperfusion injury after organ
transplantation. Reparixin is the first low molecular weight blocker of CXCL8 biological
activity in clinical development. Thus, the use of reparixin may emerge as a potential key
component in the sequentially integrated approach to immunomodulation and control of non
specific inflammatory events surrounding the early phases of pancreatic islet transplantation
in T1D patients.
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