Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children
Completed
Albert Schweitzer Hospital
Phase 3
There is a necessity for the development of new malaria drugs. Some antibiotics are also
effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be
effective against malaria, although it cannot achieve a total cure in all patients. Previous
small studies have shown that in combination with clindamycin, an commonly used antibiotic,
it is highly effective and safe when given for three days, leading to a total cure in most
patients. The current study will evaluate its efficacy in a larger population in Gabon, and
compare its effect with the generally used drug, sulfadoxine-pyrimethamine.
Treatment of Malaria in Gabon With Fosmidomycin-Clindamycin
Completed
Albert Schweitzer Hospital
Phase 2
Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic
that has been shown to be effective against malaria, although it cannot achieve a total cure
in all patients. A previous small study has shown that in combination with clindamycin, an
commonly used antibiotic, it is highly effective and safe, in asymptomatic carriers of
malaria parasites. The current study will evaluate the efficacy and safety of the combination
given for three days in children with uncomplicated malaria in Gabon.
Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate
Withdrawn
Mahidol University
Phase 2
The aim of this study is to evaluate the role of clindamycin and artesunate as possible
combination partners for fosmidomycin to protect it from its susceptibility to recrudescent
infections when used as monotherapy for acute Plasmodium falciparum malaria while retaining
its excellent safety profile
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