
| Title: | Method for administering a sustained release ranolanolazine formulation |
| Abstract: | A sustained release ranolazine formulation contains an intimate mixture of ranolazine and a partially neutralized pH-dependent binder to form a film that is mostly insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. The formulation is suitable for twice daily administration of ranolazine and is useful for controlling the rate of dissolution of ranolazine, and to maintain human plasma ranolazine levels at between 550 and 7500 ng base/mL. |
| Inventor(s): | Wolff; Andrew A. (San Francisco, CA), Baker; Fiona (Dunfermline, GB), Langridge; John Richard (Wales, GB) |
| Assignee: | CV Therapeutics, Inc. (Palo Alto, CA) |
| Application Number: | 09/321,522 |
| Patent Claim Types: | Use; Composition; Dosage form; |
| Applicant | Tradename | Generic Name | NDA | Approval Date | Type | RLD | Patent Number | Product | Substance | Delist Req. | Patent Expiration | Patented / Exclusive Use |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gilead | RANEXA | ranolazine | 021526 | Feb 12, 2007 | RX | Yes | 6,303,607 | May 27, 2019 | TREATING CHRONIC ANGINA BY ADMINISTERING AN EXTENDED RELEASE FORM OF RANOLAZINE | |||
| Gilead | RANEXA | ranolazine | 021526 | Jan 27, 2006 | RX | No | 6,303,607 | May 27, 2019 | TREATING CHRONIC ANGINA BY ADMINISTERING AN EXTENDED RELEASE FORM OF RANOLAZINE |
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