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Patent: 6,132,766

Summary for Patent: 6,132,766

Title: Multivesicular liposomes with controlled release of encapsulated biologically active substances
Abstract:A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.
Inventor(s): Sankaram; Mantripragada Bhima (San Diego, CA), Kim; Sinil (Solana Beach, CA)
Assignee: SkyePharma Inc. (San Diego, CA)
Application Number:09/045,236
Patent Claim Types:
see list of patent claims
Use; Dosage form; Device;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Pacira Pharms Inc
EXPAREL
bupivacaine
INJECTABLE, LIPOSOMAL;INJECTION022496Oct 28, 2011DISCNNo6,132,766<disabled>Y
Pacira Pharms Inc
EXPAREL
bupivacaine
INJECTABLE, LIPOSOMAL;INJECTION022496Oct 28, 2011RXYes6,132,766<disabled>Y
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International Patent Family for Patent: 6,132,766

Country Document Number Publication Date
Austria196248Sep 15, 2000
Australia1053595Jun 06, 1995
Australia686277Feb 05, 1998
Bulgaria100596Dec 31, 1996
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