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Patent: 5,741,516

Summary for Patent: 5,741,516

Title: Sphingosomes for enhanced drug delivery
Abstract:Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.
Inventor(s): Webb; Murray S. (Vancouver, CA), Bally; Marcel B. (Bowen Island, CA), Mayer; Lawrence D. (N. Vancouver, CA), Miller; James J. (Vancouver, CA), Tardi; Paul G. (Richmond, CA)
Assignee: Inex Pharmaceuticals Corporation (Vancouver, CA)
Application Number:08/572,555
Patent Claim Types:
see list of patent claims
Composition; Dosage form; Delivery; Use;
Patent PDF download available with subscription

Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Talon Therap
MARQIBO KIT
vincristine sulfate
INJECTABLE, LIPOSOMAL;INTRAVENOUS202497Aug 9, 2012RXYes5,741,516<disabled>Y
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International Patent Family for Patent: 5,741,516

Country Document Number Publication Date
Austria248586Sep 15, 2003
Australia2709495Jan 15, 1996
Canada2193502Dec 28, 1995
Germany69531701Oct 09, 2003
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