|Title:||Neuromuscular blocking agents|
|Abstract:||1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-veratrylisoquinolium) said, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been found to have an advantageous combination of pharmacological properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockade, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockage), in comparison with the known mixture of geometrical and optical isomers.|
|Inventor(s):||Hill; Derek A. (Dartford, GB2), Turner; Geoffrey L. (Dartford, GB2)|
|Assignee:||Burroughs Wellcome Co. (Research Triangle Park, NC)|
|Patent Claim Types:|
see list of patent claims
|Compound; Composition; Use;|
|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|United Kingdom||9015473||Jul 13, 1990|
|Country||Document Number||Publication Date|
|South Africa||9105468||Mar 31, 1993|
|WIPO (PCT)||9200965||Jan 23, 1992|
|United States||5556978||Sep 17, 1996|
|Slovak Republic||279907||May 07, 1999|
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