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Patent: 5,114,923

Summary for Patent: 5,114,923

Title: Recombinant techniques for production of novel natriuretic and vasodilator peptides
Abstract:The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically. The invention peptides have the formula: ##STR1## wherein R.sup.1 is selected from the group consisting of: ##STR2## or a 10- to 109-amino acid sequence shown as the native upstream sequence for porcine, canine or human NP in FIG. 6, or a composite thereof; R.sup.2 is (OH), NH.sub.2, or NR'R" wherein R' and R" are independently lower alkyl (1-4C) or is ##STR3## or the amides (NH.sub.2 or NR'R") thereof, with the proviso that if formula (1) is and R.sup.1 is Asp-Ser-Gly-, R.sup.2 cannot be Asn-Val-Leu-Arg-Arg-Tyr. The peptides of the invention can be formulated into pharmaceutical compositions and used to treat conditions associated with high extracellular fluid levels, especially congestive heart failure.
Inventor(s): Seilhamer; Jeffrey J. (Milpitas, CA), Lewicki; John A. (Los Gatos, CA), Scarborough; Robert M. (Belmont, CA), Porter; J. Gordon (Newark, CA)
Assignee: California Biotechnology Inc. (Mountain View, CA)
Application Number:07/460,855
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
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Glossary
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Scios Llc
NATRECOR
nesiritide recombinant
FOR SOLUTION;INTRAVENOUS020920Aug 10, 2001RXYes5,114,923<disabled>YYMETHOD TO INDUCE NATRIURESIS, DIURESIS AND/OR VASODILATION
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International Patent Family for Patent: 5,114,923

Country Document Number Publication Date
Austria126522Sep 15, 1995
Australia3768189Jan 05, 1990
Canada1339210Aug 05, 1997
Germany68923878Sep 21, 1995
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