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Details for Patent: 6,537,579

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Summary for Patent: 6,537,579

Title: Compositions and methods for administration of pharmacologically active compounds
Abstract:In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful election of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within.
Inventor(s): Desai; Neil P. (Los Angeles, CA), Soon-Shiong; Patrick (Los Angeles, CA)
Assignee: American BioScience, Inc. (Santa Monica, CA)
Application Number:09/574,763
Patent Claim Types:
see list of patent claims
Use; Composition; Delivery; Formulation;
Patent PDF download available with subscription

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International Patent Family for Patent: 6,537,579

Country Document Number Publication Date
Canada2512487Apr 09, 1998
Spain2435944Dec 26, 2013
New Zealand335133Dec 22, 2000
New Zealand502500Mar 28, 2002
Norway314017Jan 20, 2003
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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