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|Title:||Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivatives as therapeutic agents|
|Abstract:||The present invention provides cydopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cydopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cydopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cydopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.|
|Inventor(s):||Woodward; David F. (El Toro, CA), Andrews; Steven W. (Rancho Santa Marguerita, CA), Burk; Robert M. (Irvine, CA), Garst; Michael E. (Newport Beach, CA)|
|Assignee:||Allergan Sales, Inc. (Irvine, CA)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Publication Date|
|Denmark||0660716||Apr 02, 2002|
|Netherlands||300099||Nov 01, 2002|
|European Patent Office||0825980||Mar 04, 1998|
|World Intellectual Property Organization (WIPO)||9406433||Mar 31, 1994|
|Spain||2159734||Oct 16, 2001|
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