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Details for Patent: 5,958,446

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Summary for Patent: 5,958,446

Title: Solubility parameter based drug delivery system and method for altering drug saturation concentration
Abstract:The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.
Inventor(s): Miranda; Jesus (Miami, FL), Sablotsky; Steven (Miami, FL)
Assignee: Noven Pharmaceuticals, Inc. (Miami, FL)
Application Number:08/433,754
Patent Claim Types:
see list of patent claims
Composition; Device; Process;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,958,446

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
South Korea100391229Nov 01, 2003
JapanH06508820Oct 06, 1994
Denmark0591432Jan 06, 2003
Portugal92829Feb 29, 1996
South Africa9604735Dec 19, 1996
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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