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|Title:||Sphingosomes for enhanced drug delivery|
|Abstract:||Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of lipophilic drugs such as the vinca alkaloids, and particularly vincristine and vinblastine, to tumors is significantly improved.|
|Inventor(s):||Webb; Murray S. (Vancouver, CA), Bally; Marcel B. (Bowen Island, CA), Mayer; Lawrence D. (North Vancouver, CA)|
|Assignee:||Inex Pharmaceuticals Corporation (Vancouver, CA)|
Patent Claim Types:|
see list of patent claims
|Composition; Dosage form; Delivery; Compound; Process; Formulation;|
|Country||Document Number||Publication Date|
|World Intellectual Property Organization (WIPO)||9535094||Dec 28, 1995|
|United States of America||5741516||Apr 21, 1998|
|United States of America||5814335||Sep 29, 1998|
|Portugal||804159||Feb 27, 2004|
|Japan||H10501534||Feb 10, 1998|
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