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Details for Patent: 5,508,042

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Summary for Patent: 5,508,042

Title: Controlled release oxycodone compositions
Abstract:A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation having from about 10 to about 40 mg of oxycodone or a salt thereof is administered to a patient. The formulation provides a mean maximum plasma concentration of oxycodone from about 6 to about 60 ng/ml from a mean of about 2 to about 4.5 hours after administration, and a mean minimum plasma concentration from about 3 to about 30 ng/ml from about 10 to about 14 hours after repeated "q12h" (i.e. every 12 hour) administration through steady-state conditions. Another embodiment is directed to a method for substantially reducing the range in daily dosages required to control pain in substantially all patients by administering an oral solid controlled release dosage formulation comprising up to about 160 mg of oxycodone or a salt thereof, such that a mean maximum plasma concentration of oxycodone up to about 240 ng/ml from a mean of up to about 2 to about 4.5 hours after administration, and a mean minimum plasma concentration up to about 120 ng/ml from about 10 to about 14 hours after repeated "q12h" (i.e., every 12 hour) administration through steady-state conditions are achieved. Controlled release oxycodone formulations for achieving the above are also disclosed.
Inventor(s): Oshlack; Benjamin (New York, NY), Chasin; Mark (Manalpan, NJ), Minogue; John J. (Mount Vernon, NY), Kaiko; Robert F. (Weston, CT)
Assignee: Euro-Celtigue, S.A. (Luxembourg, LU)
Application Number:08/467,584
Patent Claim Types:
see list of patent claims
Use; Formulation; Dosage form;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,508,042

Country Document Number Publication Date
Austria454150Jan 15, 2010
Austria365041Jul 15, 2007
Austria360421May 15, 2007
Austria332691Aug 15, 2006
Austria261727Apr 15, 2004
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