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|Title:||Insulin analog formulations|
|Abstract:||The present invention discloses a human insulin analog hexamer complex and formulations. More specifically, the present invention relates to various parenteral formulations, which comprise: human insulin analogs in a hexamer conformation, zinc ions, and at least three molecules of a phenolic derivative selected from the group consisting of m-cresol, phenol, or a mixture of m-cresol and phenol. The formulation provides a rapid onset of action.|
|Inventor(s):||Bakaysa; Diane L. (Indianapolis, IN), Brems; David N. (Indianapolis, IN), Frank; Bruce H. (Indianapolis, IN), Havel; Henry A. (Indianapolis, IN), Pekar; Allen H. (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
Patent Claim Types:|
see list of patent claims
|Formulation; Composition; Use;|
|Country||Document Number||Publication Date||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Portugal||101722||Dec 29, 1995|
|United Kingdom||9512038||Aug 09, 1995|
|Norway||952357||Jun 14, 1995|
|Luxembourg||88626||Feb 01, 1996|
|Spain||2091727||Nov 01, 1996|
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