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|Title:||Insulin analog formulations|
|Abstract:||The present invention discloses a human insulin analog hexamer complex and formulations. More specifically, the present invention relates to various parenteral formulations, which comprise: human insulin analogs in a hexamer conformation, zinc ions, and at least three molecules of a phenolic derivative selected from the group consisting of m-cresol, phenol, or a mixture of m-cresol and phenol. The formulation provides a rapid onset of action.|
|Inventor(s):||Bakaysa; Diane L. (Indianapolis, IN), Brems; David N. (Indianapolis, IN), Frank; Bruce H. (Indianapolis, IN), Havel; Henry A. (Indianapolis, IN), Pekar; Allen H. (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
Patent Claim Types:|
see list of patent claims
|Formulation; Composition; Use;|
|Country||Document Number||Publication Date||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Portugal||101722||Feb 28, 1997|
|Sweden||9502167||Dec 17, 1995|
|Romania||113530||Aug 28, 1998|
|Taiwan||421596||Feb 11, 2001|
|France||2721214||Sep 26, 1997|
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