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Details for Patent: 5,474,978

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Summary for Patent: 5,474,978

Title: Insulin analog formulations
Abstract:The present invention discloses a human insulin analog hexamer complex and formulations. More specifically, the present invention relates to various parenteral formulations, which comprise: human insulin analogs in a hexamer conformation, zinc ions, and at least three molecules of a phenolic derivative selected from the group consisting of m-cresol, phenol, or a mixture of m-cresol and phenol. The formulation provides a rapid onset of action.
Inventor(s): Bakaysa; Diane L. (Indianapolis, IN), Brems; David N. (Indianapolis, IN), Frank; Bruce H. (Indianapolis, IN), Havel; Henry A. (Indianapolis, IN), Pekar; Allen H. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:08/260,634
Patent Claim Types:
see list of patent claims
Formulation; Composition; Use;
Patent PDF download available with subscription

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International Patent Family for Patent: 5,474,978

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
South Africa9504943Sep 14, 1997
ItalyMI951278Jun 14, 1995
Peru19496Jun 01, 1996
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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