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Details for Patent: 5,457,105

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Summary for Patent: 5,457,105

Title: Quinazoline derivatives useful for treatment of neoplastic disease
Abstract:The invention concerns quinazoline derivatives of the formula I ##STR1## wherein m is 1, 2 or 3 and each R.sup.1 includes hydroxy, amino, carboxy, carbamoyl, ureido, (1-4C)alkoxycarbonyl, N-(1-4C)alkylcarbamoyl, N,N-di-[(1-4C)alkyl]carbamoyl, hydroxyamino, (1-4C)alkoxyamino, (2-4C)alkanoyloxyamino, trifluoromethoxy, (1-4C)alkyl, (1-4C)alkoxy and (1-3C)alkylenedioxy; n is 1 or 2 and each R.sup.2 includes hydrogen, hydroxy, halogeno, trifluoromethyl, amino, nitro, cyano and (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.
Inventor(s): Barker; Andrew J. (Macclesfield, GB2)
Assignee: Zeneca Limited (London, GB2)
Application Number:08/284,293
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
Patent PDF download available with subscription

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Foreign Priority and PCT Information for Patent: 5,457,105

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9201095Jan 20, 1992
United Kingdom9213572Jun 26, 1992
United Kingdom9223735Nov 12, 1992

International Patent Family for Patent: 5,457,105

Country Document Number Publication Date
Austria130000Nov 15, 1995
Australia661533Jul 27, 1995
Australia3101093Jul 22, 1993
Canada2086968Jul 21, 1993
Czech Republic282038Apr 16, 1997
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