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Details for Patent: 5,453,510

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Summary for Patent: 5,453,510

Title: Neuromuscular blocking agents
Abstract:1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-veratrylisoquinolium) said, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been found to have an advantageous combination of pharmacological properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockade, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockage), in comparison with the known mixture of geometrical and optical isomers.
Inventor(s): Hill; Derek A. (Dartford, GB2), Turner; Geoffrey L. (Dartford, GB2)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:07/911,887
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;
Patent PDF download available with subscription

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Foreign Priority and PCT Information for Patent: 5,453,510

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9015473Jul 13, 1990

International Patent Family for Patent: 5,453,510

Country Document Number Publication Date Supplementary Protection Certificate SPC Country SPC Expiration
United Kingdom2260763Apr 28, 1993
Spain2088009Aug 01, 1996
Slovakia279907May 07, 1999
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Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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