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Details for Patent: 5,360,800

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Summary for Patent: 5,360,800

Title: Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
Abstract:The invention relates to tricyclic lactams of the general formula (I) ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## and R.sup.1 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, phenyl, phenyl C.sub.1-3 alkyl, phenylmethoxymethyl, phenoxyethyl or phenoxymethyl, one of the groups represented by R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, phenyl or phenyl C.sub.1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkhyl group; n represents 2 or 3; and physiologically acceptable salts and solvates thereof. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.
Inventor(s): Coates; Ian H. (Hertford, GB2), North; Peter C. (Royston, GB2), Oxford; Alexander W. (Royston, GB2)
Assignee: Glaxo Group Limited (London, GB2)
Application Number:07/741,570
Patent Claim Types:
see list of patent claims
Compound; Composition; Dosage form; Use;
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Foreign Priority and PCT Information for Patent: 5,360,800

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8720695Sep 03, 1987
United Kingdom8819382Aug 15, 1988

International Patent Family for Patent: 5,360,800

Country Document Number Publication Date
South Africa8806538Jul 26, 1989
United States5008272Apr 16, 1991
Slovak Republic404491Dec 11, 2000
Portugal88409Jul 31, 1989
Philippines25493Jul 24, 1991
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