Details for Patent: 8,790,641
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Summary for Patent: 8,790,641
| Title: | Production of high mannose proteins in plant culture and therapeutic uses thereof |
| Abstract: | A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases. |
| Inventor(s): | Shaaltiel; Yoseph (Kibbutz HaSolelim-Doar-Na HaMovil, IL), Baum; Gideon (D.N. Upper Galilee, IL), Bartfeld; Daniel (Moran-Doar-Na Bikat Beit HaKerem, IL), Hashmueli; Sharon (Ramot-Naftali, IL), Lewkowicz; Ayala (Kfar-Vradim, IL) |
| Assignee: | Protalix Ltd. (Carmiel, IL) |
| Application Number: | 12/385,894 |
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Patent Claim Types: see list of patent claims | Use; |
Drugs Protected by US Patent 8,790,641
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 8,790,641
| Foriegn Application Priority Data | ||
| Foreign Country | Foreign Patent Number | Foreign Patent Date |
| Israel | 155588 | Apr 27, 2003 |
International Family Members for US Patent 8,790,641
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Austria | E231912 | ⤷ Try a Trial | |||
| Australia | 2004234635 | ⤷ Try a Trial | |||
| Australia | 2005214181 | ⤷ Try a Trial | |||
| Australia | 2008243744 | ⤷ Try a Trial | |||
| Australia | 4318097 | ⤷ Try a Trial | |||
| Brazil | PI0410520 | ⤷ Try a Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
