Therapeutic Equivalence Between Branded and Generic WARFArin Tablets in Brazil
Completed
Fundação de Amparo à Pesquisa do Estado de São Paulo
Phase 4
2014-08-01
The purpose of this study is to assess whether the switch from branded to generic warfarin or
between different generic warfarin tablets may cause fluctuation in the results of
coagulation tests (International Normalized Rate, acronym INR) in patients, thus predisposing
them to unnecessary risks.
Therapeutic Equivalence Between Branded and Generic WARFArin Tablets in Brazil
Completed
Federal University of São Paulo
Phase 4
2014-08-01
The purpose of this study is to assess whether the switch from branded to generic warfarin or
between different generic warfarin tablets may cause fluctuation in the results of
coagulation tests (International Normalized Rate, acronym INR) in patients, thus predisposing
them to unnecessary risks.
The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline
Unknown status
Xijing Hospital
Phase 1/Phase 2
2014-03-01
The mortality of pneumonia with extensively drug resistant Acinetobacter baumannii (XDRAB) is
still high, even if these patients received certain strong anti-infection treatment such us
the combination of cefoperazone-sulbactam (C/S) and minocycline. Health airway lining fluid
is mildly alkaline but airway acidification usually appears for the infection of XDRAB. The
hypothesis is offered that the biologic activity of XDRAB might be inhibited if the
circumstance including pH is changed. In the vitro study we observed that the inhibit effect
of antibiotics on XDRAB growth was improved significantly by alkaline solution within the
scope of physiology. So the aim of this clinical study is to explore the effects of
nebulization of alkaline Solution on C/S plus minocycline on the pneumonia with XDRAB.
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