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Details for Patent: 6,287,539

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Summary for Patent: 6,287,539

Title: Methods of imaging using osmotically stabilized microbubble preparations
Abstract:A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.
Inventor(s): Schutt; Ernest G. (San Diego, CA), Anderson; Charles David (Lebanon, NJ), Evitts; David P. (La Jolla, CA)
Assignee: Alliance Pharmaceuticals Corp. (San Diego, CA)
Application Number:08/841,846
Patent Claim Types:
see list of patent claims
Use; Dosage form; Compound;
Patent Metrics:
Source: PatentQuant.com
Field: Medical technology
Back Citations: 99th percentile
Forward Citations: 0th percentile
Patent PDF download available with subscription

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Premature patent expiration for: 6,287,539

Expiration due to failure to pay maintenance fee

Patent Number Expiration Date
6,287,539 September 11, 2013

International Patent Family for Patent: 6,287,539

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria281183<disabled in preview>
Australia4922196<disabled in preview>
Australia5199701<disabled in preview>
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