Details for Patent: 4,770,183

Summary for Patent: 4,770,183

Title:	Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
Abstract:	This invention relates to an improved method for obtaining the in vivo MNR image of an organ or tissue of an animal or human subject. More specifically, this invention relates to the use of small (about 10 to about 5,000 angstroms in diameter) biodegradable superparamagnetic metal oxide particles for use as imaging agents. The particles, which may be uncoated or surrounded by a stable polymeric coating, can be mixed with a physiologically acceptable medium to form a uniform dispersoid which can be administered to the subject by a variety of routes. Once administered, the particles collect in the target organ or tissue where they will remain for a time sufficiently long for an image to be obtained, but are ultimately metabolized or cleared within about 7 days.
Inventor(s):	Groman; Ernest V. (Brookline, MA), Josephson; Lee (Arlington, MA)
Assignee:	Advanced Magnetics Incorporated (Cambridge, MA)
Application Number:	06/882,044
Patent Claim Types: see list of patent claims	Use; Composition; Dosage form;

Drugs Protected by US Patent 4,770,183

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 4,770,183

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	135920
Austria	139431
Austria	142891
Austria	143604
Austria	143814