Details for Patent: 4,021,481

Summary for Patent: 4,021,481

Title:	Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
Abstract:	This invention relates to novel X-ray contrast agents particularly for use in the cerebrospinal cavities, comprising non-ionic alkanols carrying at least one N-bonded secondary or tertiary amide group and having at least two hydroxyl groups and at least one iodine atom in the molecule. Particularly useful compounds include the N-hydroxyalkyl iodoalkane sulphonamides having at least two hydroxyl groups, tri- and tetra-iodobenzene carrying carbamoyl, acylamino and/or acylaminomethyl substituents and having at least two hydroxyl groups in the molecule and at least one N-hydroxyalkyl group. Particularly preferred compounds comprise 2,4,6-triiodobenzamides which may be 3- and/or 5-substituted with a variety of groups. The compounds all show markedly low toxicities and a number show very high levels of water solubility.
Inventor(s):	Almen; Torsten (Oslo, NO), Haavaldsen; Johan (Oslo, NO), Nordal; Vegard (Oslo, NO)
Assignee:	Nyegaard & Co. A/S (Oslo, NO)
Application Number:	05/528,842
Patent Claim Types: see list of patent claims	Compound;

Drugs Protected by US Patent 4,021,481

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

Foreign Priority and PCT Information for Patent: 4,021,481

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
	32699/69	Jun 27, 1969
	6130/70	Feb 9, 1970

International Family Members for US Patent 4,021,481

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	318134
Belgium	752574
Brazil	7020080
Canada	935153
Switzerland	544551
Germany	2031724