Details for Patent: 8,030,312
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Title: | 5-HT1A receptor subtype agonist |
Abstract: | The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT.sub.1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1): ##STR00001## wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond. |
Inventor(s): | Jordan; Shaun (Germantown, MD), Kikuchi; Tetsuro (Tokushima, JP), Tottori; Katsura (Kamiita-cho, JP), Hirose; Tsuyoshi (Tokushima, JP), Uwahodo; Yasufumi (Tokushima, JP) |
Assignee: | Otsuka Pharmaceutical Co., Ltd. (Tokyo, JP) |
Filing Date: | Jun 28, 2004 |
Application Number: | 10/876,605 |
Claims: | 1. A method of treating a patient suffering from, obsessive compulsive disorder (OCD), which comprises administering to said patient a therapeutically effective amount of a carbostyril compound of formula (1), or a pharmaceutically acceptable salt, or a solvate thereof selected from hemihydrates, hydrates, and alcoholates, wherein said patient is a mammal: ##STR00003## wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond. 2. The method according to claim 1, wherein the carbostyril compound is 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxyl}-3,4-dihydrocarbostyri- l. 3. A method of treating a patient suffering from alcohol addiction, which comprises administering to said patient a therapeutically effective amount of a carbostyril compound of formula (1), or a pharmaceutically acceptable salt, or a solvate thereof selected from hemihyd rates, hydrates, and alcoholates, wherein said patient is a mammal: ##STR00004## wherein the carbon-carbon bond between 3- and 4- positions in the carbostyril skeleton is a single or a double bond. 4. The method according to claim 3, wherein the carbostyril compound is 7-{4-[4-(2,3-diichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydrocarbostyri- l. 5. A method of treating a patient suffering from drug addiction, which comprises administering to said patient a therapeutically effective amount of a carbostyril compound of formula (1), or a pharmaceutically acceptable salt, or a solvate thereof selected from hemihyd rates, hydrates, and alcoholates, wherein said patient is a mammal: ##STR00005## wherein the carbon-carbon bond between 3- and 4- positions in the carbostyril skeleton is a single or a double bond. 6. The method according to claim 5, wherein the carbostyril compound is 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxyl}-3,4-dihydrocarbostyri- l. |