Claims for Patent: 11,426,407

Summary for Patent: 11,426,407

Title:	Modulators of cystic fibrosis transmembrane conductance regulator
Abstract:	The present invention features a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, where R.sub.1, R.sub.2, R.sub.3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
Inventor(s):	Miller; Mark Thomas (San Diego, CA), Anderson; Corey (San Diego, CA), Arumugam; Vijayalaksmi (San Marcos, CA), Bear; Brian Richard (Carlsbad, CA), Binch; Hayley Marie (Encinitas, CA), Clemens; Jeremy J. (San Diego, CA), Cleveland; Thomas (San Diego, CA), Conroy; Erica (Columbus, OH), Coon; Timothy Richard (Carlsbad, CA), Frieman; Bryan A. (La Jolla, CA), Grootenhuis; Peter Diederik Jan (San Diego, CA), Gross; Raymond Stanley (Poway, CA), Hadida-Ruah; Sara Sabina (La Jolla, CA), Khatuya; Haripada (San Diego, CA), Joshi; Pramod Virupax (San Diego, CA), Krenitsky; Paul John (San Diego, CA), Lin; Chun-Chieh (San Diego, CA), Marelius; Gulin Erdogan (San Diego, CA), Melillo; Vito (Escondido, CA), McCartney; Jason (Cardiff by the Sea, CA), Nicholls; Georgia McGaughey (Winchester, MA), Pierre; Fabrice Jean Denis (La Jolla, CA), Silina; Alina (San Diego, CA), Termin; Andreas P. (Encinitas, CA), Uy; Johnny (San Diego, CA), Zhou; Jinglan (San Diego, CA)
Assignee:	Vertex Pharmaceuticals Incorporated (Boston, MA)
Application Number:	16/836,155
Patent Claims:	1. A compound of formula Ib: ##STR03798## a pharmaceutically acceptable salt thereof, or a deuterated derivative of any of the foregoing, wherein, independently for each occurrence: Ring B is a C6-C10 aryl ring or C3-C10 heteroaryl or heterocyclic ring wherein anywhere from 1 to 4 ring atoms are independently O, S, N, or NR; Ring C is a C6-C10 aryl ring, C3-C14 heteroaryl or heterocyclic ring wherein anywhere from 1 to 4 ring atoms are independently N, O, or S, or a C3-C10 mono- or bicyclic cycloalkyl ring; Y is CRR, CO, O, S, SO, SO.sub.2, S(O)NH or NR; R.sub.1 is halo; CN; F.sub.5S; SiR.sub.3; OH; NRR; C1-C6 alkyl or fluoroalkyl; C1-C6 alkoxy or fluoroalkoxy; C2-C6 alkenyl; C2-C6 alkynyl; (C1-C9 alkylene)-R.sub.4 wherein up to four CH.sub.2 units are independently replaced with O, CO, S, SO, SO.sub.2 or NR; C6-C10 aryl; C3-C10 heteroaryl or heterocyclic ring wherein anywhere from 1 to 4 ring atoms are independently O, S, N, or NR; or C3-C10 cycloalkyl; R.sub.2 is halo; OH; NRR; azide; CN; CO.sub.2R; C1-C6 alkyl or fluoroalkyl; C1-C6 alkoxy or fluoroalkoxy; C2-C6 alkenyl; C2-C6 alkynyl; C6-C10 aryl; C3-C13 heteroaryl or heterocyclic ring wherein anywhere from 1 to 4 ring atoms are independently O, S, N, or NR; C3-C10 cycloalkyl; or a (C1-C9 alkylene)-R.sub.4 wherein up to four CH.sub.2 units are independently replaced with O, CO, S, SO, SO.sub.2 or NR; or two R.sub.2 groups taken together may form a .dbd.CH.sub.2 or .dbd.O group; R.sub.3 is halo; CN; CO.sub.2R; C1-C6 alkyl or fluoroalkyl; C2-C6 alkenyl; C2-C6 alkynyl; C1-C6 alkoxy or fluoroalkoxy; or C6-C10 aryl; C3-C10 heteroaryl or heterocyclic ring wherein anywhere from 1 to 4 ring atoms are independently O, S, N, or NR; C3-C10 cycloalkyl; or a (C1-C9 alkylene)-R.sub.4 wherein up to four CH.sub.2 units are independently replaced with O, CO, S, SO, SO.sub.2 or NR; or two R.sub.3 groups taken together may form a .dbd.CH.sub.2 or .dbd.O group; R.sub.4 is H; azide; CF.sub.3; CHF.sub.2; OR; CCH; CO.sub.2R; OH; C6-C10 aryl, C3-C10 heteroaryl or heterocycloalkyl wherein anywhere from 1 to 4 ring atoms are independently O, S, N, or NR; C3-C10 cycloalkyl; NRR, NRCOR, CONRR, CN, halo, or SO.sub.2R; R is independently H; OH; CO.sub.2H; CO.sub.2C1-C6 alkyl; C1-C6 alkyl; C2-C6 alkenyl; C2-C6 alkynyl; C6-C10 aryl; C3-C10 heteroaryl or heterocycloalkyl wherein anywhere from 1 to 4 ring atoms are independently O, S, N, or NR; or C3-C10 cycloalkyl; n is 0, 1, 2 or 3; o is 0 or 1; p is 0, 1, 2, or 3; and q is 0, 1, 2, 3, 4, or 5. 2. The compound, salt, or deuterated derivative of claim 1, wherein ring B is phenyl, pyridyl, pyridine-2(1H)-one, pyrazole, indole, thiophene, dihydrobenzofuran, pyrazine, indazole, thiazole, pyridine-4(1H)-one, pyrrolidinone, or quinoline. 3. The compound, salt, or deuterated derivative of claim 1, wherein ring B is selected from ##STR03799## 4. The compound, salt, or deuterated derivative of claim 1, wherein ring C is phenyl, indole, cycloalkyl, pyridyl, pyrrolidine, naphthalene, or dihydroindene. 5. The compound, salt, or deuterated derivative of claim 1, wherein ring C is ##STR03800## ##STR03801## 6. The compound, salt, or deuterated derivative of claim 1, wherein Y is O. 7. The compound, salt, or deuterated derivative of claim 1, wherein Y is CH.sub.2. 8. The compound, salt, or deuterated derivative of claim 1, wherein Y is CH(C1-C6 aliphatic). 9. The compound, salt, or deuterated derivative of claim 1, wherein Y is CH(CH.sub.3). 10. The compound, salt, or deuterated derivative of claim 1, wherein Y is CH(CH.sub.2CH.sub.3). 11. The compound, salt, or deuterated derivative of claim 1, wherein R.sub.1 is halo, CN, C1-C6 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, or a phenyl, pyridyl, pyrimidine, indole, aza-indole, or thiophene ring, wherein all rings may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 fluoroalkyl, C1-C6 fluoroalkoxy, OH, CH.sub.2OH, CH.sub.2OCH.sub.3, CN, CO.sub.2H, amino, amido, C3-C10 heteroaryl, C3-C10 heterocycloalkyl, or a (C1-C8 alkyl)-R.sub.4 wherein up to three CH.sub.2 units may be replaced with O, CO, S, SO, SO.sub.2 or NR. 12. The compound, salt, or deuterated derivative of claim 1, wherein R.sub.1 is selected from CH.sub.3, Cl, F, CN, OCH.sub.3, CF.sub.3, CH.sub.2CH.sub.3, tBu, CH(CH.sub.3).sub.2, ##STR03802## ##STR03803## ##STR03804## ##STR03805## ##STR03806## ##STR03807## ##STR03808## 13. The compound, salt, or deuterated derivative of claim 1, wherein R.sub.2 is selected from halo, OH, CN, azide, amino, C1-C6 alkyl or fluoroalkyl, C1-C6 alkoxy or fluoroalkoxy, C3-C10 mono- or bicyclic heterocyclic ring wherein up to 4 carbon atoms may be replaced with O, S, N, or NR; or a (C1-C8 alkyl)-R.sub.4 wherein up to three CH.sub.2 units may be replaced with O, CO, S, SO, SO.sub.2 or NR. 14. The compound, salt, or deuterated derivative of claim 1, wherein R.sub.2 is selected from Cl, F, OH, CN, N.sub.3, NH.sub.2, NH(CH.sub.3), N(CH.sub.3).sub.2, CH.sub.3, CH.sub.2OH, CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CHF.sub.2, OCH.sub.3, OCF.sub.3, OCHF.sub.2, OCH(CH.sub.3).sub.2, C(O)CH.sub.3, CH.sub.2CH.sub.2OH, CH.sub.2NH.sub.2, NH(CH.sub.2).sub.2OH, NH(CH.sub.2).sub.2N(CH.sub.3).sub.2, NH(CH.sub.2).sub.2NH.sub.2, NH(CH.sub.2).sub.3NH.sub.2, NH(CH.sub.2).sub.2OCH.sub.3, NHCH(CH.sub.3).sub.2, ##STR03809## 15. The compound, salt, or deuterated derivative of claim 1, wherein R.sub.3 is selected from halo, CN, C1-C6 alkyl or fluoroalkyl, C1-C6 alkoxy, or C3-C10 mono- or bicyclic heteroaryl wherein up to 4 carbon atoms may be replaced by O, S, N, or NR. 16. The compound, salt, or deuterated derivative of claim 1, wherein R.sub.3 is selected from Cl, F, CN, CH.sub.3, OCH.sub.3, CF.sub.3, CH.sub.2CH.sub.3, CH.sub.2CF.sub.3, CH.sub.2CH.sub.2CH.sub.3, OCH.sub.2CH.sub.3, CH.sub.2OCH.sub.3, CH(CH.sub.3).sub.2, CCH, CO.sub.2CH.sub.3, tBu, .dbd.CH.sub.2, .dbd.O, ##STR03810## 17. The compound, salt, or deuterated derivative of claim 1, wherein o is 0. 18. The compound, salt, or deuterated derivative of claim 1, wherein o is 1. 19. The compound, salt, or deuterated derivative of claim 1, wherein n is 0. 20. The compound, salt, or deuterated derivative of claim 1, wherein n is 1. 21. The compound, salt, or deuterated derivative of claim 1, wherein n is 2. 22. The compound, salt, or deuterated derivative of claim 1, wherein p is 0. 23. The compound, salt, or deuterated derivative of claim 1, wherein p is 1. 24. The compound, salt, or deuterated derivative of claim 1, wherein p is 2. 25. The compound, salt, or deuterated derivative of claim 1, wherein ring B is pyridyl. 26. The compound, salt, or deuterated derivative of claim 1, wherein ring B is phenyl. 27. The compound, salt, or deuterated derivative of claim 1, wherein ring B and ring C are phenyl. 28. A compound selected from: N-[(6-amino-2-pyridyl)sulfonyl]-6-benzyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 1), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2,4-dimethylphenyl)pyridine-3-c- arboxamide (Compound 5), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutoxyphenyl)-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 8), N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethylphenoxy)pyridine- -3-carboxamide (Compound 11), N-(3-aminophenyl)sulfonyl-6-methyl-2-(2,4,6-trimethylphenoxy)pyridine-3-c- arboxamide (Compound 13), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)- -2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 14), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-methoxyphenyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 17), N-[(3-aminophenyl)sulfonimidoyl]-6-tert-butyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 19), N-(benzenesulfonyl)-6-tert-butyl-3-[(2,4,6-trimethylphenyl)methyl]pyridin- e-2-carboxamide (Compound 22), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethylphenyl)pyridine-- 3-carboxamide (Compound 26), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(m-tolyl)pyridine-3-carbox- amide (Compound 31), 6-tert-butyl-N-[(6-methoxy-2-pyridyl)sulfonyl]-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 34), N-(3-amino-1-methyl-pyrazol-4-yl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 41), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(4-fluorophenyl)pyridine-3-carbo- xamide (Compound 46), 6-tert-butyl-N-(3-hydroxyphenyl)sulfonyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 47), 6-tert-butyl-N-(3-ethylphenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamide (Compound 50), 6-tert-butyl-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 51), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(3,5-dimethylphenyl)pyridine-3-c- arboxamide (Compound 52), N-[(3-aminophenyl)sulfonimidoyl]-6-tert-butyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 53), N-[(6-amino-2-pyridyl)sulfonyl]-6-cyclopropyl-4-(trifluoromethyl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 54), 6-tert-butyl-2-(2,4-dimethylphenoxy)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]p- yridine-3-carboxamide (Compound 55), 6-tert-butyl-N-(3-methoxyphenyl)sulfonyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 56), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(p-tolyl)pyridine-3-carbox- amide (Compound 58), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-ethoxyphenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 61), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isopropylpyrimidin-5-yl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 64), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(methoxymethyl)phenyl]-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 66), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(methoxymethyl)phenyl]-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 69), 6-(4-chloro-3-propoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 72), N-(benzenesulfonyl)-6-tert-butyl-2-(p-tolyl)pyridine-3-carboxamide (Compound 774), 6-tert-butyl-N-[(6-methoxy-2-pyridyl)sulfonyl]-2-(p-tolyl)pyridine-3-carb- oxamide (Compound 75), 6-tert-butyl-N-(2-cyanophenyl)sulfonyl-2-(2,4,6-trimethylphenoxy)pyridine- -3-carboxamide (Compound 78), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(N-methylanilino)pyridine-3-carb- oxamide (Compound 85), 6-tert-butyl-2-(2,4-dimethylphenoxy)-N-[(2-methoxy-3-pyridyl)sulfonyl]pyr- idine-3-carboxamide (Compound 89), 6-tert-butyl-N-[(3-methoxy-2-pyridyl)sulfonyl]-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 92), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-fluorophenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 93), N-(3-aminophenyl)sulfonyl-6-(trifluoromethyl)-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 96), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,6-dimethylphenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 97), N-(benzenesulfonyl)-6-tert-butyl-2-(3-methoxyphenoxy)pyridine-3-carboxami- de (Compound 101), N-(3-aminophenyl)sulfonyl-6-tert-butyl-3-(2,4,6-trimethylphenoxy)pyridine- -2-carboxamide (Compound 106), 6-tert-butyl-N-[(4-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 107), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(4-cyano-2,6-dimethyl-phenoxy)py- ridine-3-carboxamide (Compound 111), 6-tert-butyl-N-[(2-oxo-1H-pyridin-4-yl)sulfonyl]-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 113), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(3-isopropyl- -1-piperidyl)pyridine-3-carboxamide (Compound 114), 6-tert-butyl-N-(2-methoxyphenyl)sulfonyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 115), 6-tert-butyl-N-(4-pyridylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridine-3-c- arboxamide (Compound 117), N-(3-aminophenyl)sulfonyl-5-cyano-6-methyl-2-(2,4,6-trimethylphenoxy)pyri- dine-3-carboxamide (Compound 124), 6-(3-isoButoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 125), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-[4-(trifluoromethyl)phenyl]pyrid- ine-3-carboxamide (Compound 129), N-(benzenesulfonyl)-2-benzyloxy-6-tert-butyl-pyridine-3-carboxamide (Compound 130), 6-tert-butyl-N-(2-hydroxyphenyl)sulfonyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 131), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(trifluoromethyl)-3-pyridyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 132), 6-(4-chloro-3-isobutoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 136), 6-tert-butyl-N-(1-methylindol-4-yl)sulfonyl-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 146), N-(benzenesulfonyl)-6-tert-butyl-2-(2-isopropylphenoxy)pyridine-3-carboxa- mide (Compound 147), N-(benzenesulfonyl)-6-tert-butyl-2-(2-pyridylmethoxy)pyridine-3-carboxami- de (Compound 154), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxy-3-fluoro-phenyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 161), N-[(5-amino-3-pyridyl)sulfonyl]-6-tert-butyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 163), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropylphenyl)-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 164), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 169), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 171), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-methylcyclohexyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 172), N-[(6-amino-2-pyridyl)sulfonyl]-6-(trifluoromethyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 175), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(4-fluoro-3-methyl-phenyl)pyridi- ne-3-carboxamide (Compound 177), 6-(4-ethoxyphenyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 190), 6-tert-butyl-N-[(2-methoxy-3-pyridyl)sulfonyl]-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 191), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(N,2-dimethylanilino)pyridine-3-- carboxamide (Compound 193), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 196), N-[(6-amino-2-pyridyl)sulfonyl]-6-phenyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 203), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2,4-dimethylphenoxy)pyrid- ine-3-carboxamide (Compound 204), 3-[[6-tert-butyl-2-(2,4,6-trimethylphenoxy)pyridine-3-carbonyl]sulfamoyl]- benzoic acid (Compound 205), 6-tert-butyl-N-(4-methoxyphenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamid- e (Compound 206), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-2-fluoro-phenyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 207), 6-tert-butyl-N-(1H-pyrazol-5-ylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 214), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-cyanophenyl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 216), 6-tert-butyl-N-[(2-methoxy-4-pyridyl)sulfonyl]-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 217), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(1-phenylethoxy)pyridine-3-carbo- xamide (Compound 219), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2-cyano-4,6-dimethyl-phenoxy)py- ridine-3-carboxamide (Compound 221), 6-tert-butyl-N-(2-pyridylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridine-3-c- arboxamide (Compound 222), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(4-chlorophenyl)pyridine-3-carbo- xamide (Compound 223), N-[(6-Amino-3-fluoro-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 226), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 228), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(3-tert-butylphenyl)pyridine-3-c- arboxamide (Compound 229), N-(3-aminophenyl)sulfonyl-6-phenyl-2-(2,4,6-trimethylphenoxy)pyridine-3-c- arboxamide (Compound 231), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(3R)-3-phen- yl-1-piperidyl]pyridine-3-carboxamide (Compound 233), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chlorophenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 234), N-[(2-amino-3-pyridyl)sulfonyl]-6-tert-butyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 235), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(3-fluoro-5-methyl-phenyl)pyridi- ne-3-carboxamide (Compound 237), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-isobutoxy-phenyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 238), N-(3-aminophenyl)sulfonyl-2-(2,6-dimethylphenoxy)-6-(trifluoromethyl)pyri- dine-3-carboxamide (Compound 243), N-(benzenesulfonyl)-6-(trifluoromethyl)-2-(2,4,6-trimethylphenoxy)pyridin- e-3-carboxamide (Compound 244), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,6-dimethylphenoxy)-6-(trifluoromethy- l)pyridine-3-carboxamide (Compound 246), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-ethoxyphenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 250), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2,4-dimethylphenoxy)pyridine-3-- carboxamide (Compound 251), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(4-tert-butylphenyl)pyridine-3-c- arboxamide (Compound 252), 6-tert-butyl-N-[[6-(methylamino)-2-pyridyl]sulfonyl]-2-(2,4,6-trimethylph- enoxy)pyridine-3-carboxamide (Compound 262), N-(4-Aminothiazol-2-yl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 265), N-[(6-amino-2-pyridyl)sulfonyl]-6-phenethyl-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 268), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(1-phenylethyl)pyridine-3-carbox- amide (Compound 271), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-phenoxy-pyridine-3-carboxamide (Compound 272), N-[(6-Amino-2-pyridyl)sulfonyl]-6-(tert-butylamino)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 273) N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(3,4-dimethylphenyl)pyridine-3-c- arboxamide (Compound 274), 6-tert-butyl-N-(1H-indol-4-ylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridine- -3-carboxamide (Compound 275), 6-(2-fluoro-5-isobutoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 279), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-isopropoxy-phenyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 281), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(m-tolyl)pyridine-3-carboxamide (Compound 282), N-[(2-amino-4-pyridyl)sulfonyl]-6-tert-butyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 283), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-furyl)-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 284), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2,6-dimethylphenoxy)pyridine-3-- carboxamide (Compound 286), 6-tert-butyl-N-(4-cyanophenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamide (Compound 288), 6-tert-butyl-N-[3-(methylamino)phenyl]sulfonyl-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 289), N-[(3-Aminophenyl)sulfonimidoyl]-6-tert-butyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 292), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethylphenoxy)pyridine- -3-carboxamide (Compound 294), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2-methylphenoxy)pyridine-3-carb- oxamide (Compound 296), N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-(p-tolyl)pyridine-3-carboxamide (Compound 297), 6-(p-tolyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridin- e-3-carboxamide (Compound 300), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(p-tolyl)pyridine-3-carboxamide (Compound 301), 6-tert-butyl-N-[(6-oxo-1H-pyridin-2-yl)sulfonyl]-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 305), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(3-fluoro-5-isobutoxy-phenyl)-N- -[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 307), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-indan-5-yl-pyridine-3-carboxamid- e (Compound 308), 6-tert-butyl-N-[3-(dimethylamino)phenyl]sulfonyl-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 311), N-(3-aminophenyl)sulfonyl-6-tert-butyl-3-[(2,4,6-trimethylphenyl)methyl]p- yridine-2-carboxamide (Compound 313), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(4-isopropylphenyl)pyridine-3-ca- rboxamide (Compound 314), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 318), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isobutoxyphenyl)-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 320), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(3-methyl-1-- piperidyl)pyridine-3-carboxamide (Compound 321), N-(2-aminophenyl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethylphenoxy)pyridine- -3-carboxamide (Compound 322), N-(benzenesulfonyl)-6-tert-butyl-2-(1-methylindol-7-yl)oxy-pyridine-3-car- boxamide (Compound 326), 6-tert-butyl-N-(3-methoxyphenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamid- e (Compound 327), 6-tert-butyl-N-(3-pyridylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridine-3-c- arboxamide (Compound 330), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-phenyl-pyridine-3-carboxam- ide (Compound 334), N-[(6-Amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 337), N-(3-aminophenyl)sulfonyl-6-tert-butyl-4-(2,4,6-trimethylphenoxy)pyridine- -3-carboxamide (Compound 338), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylphenoxy)-6-phenyl-pyridine- -3-carboxamide (Compound 340), N-(benzenesulfonyl)-6-tert-butyl-2-(2,4,6-trimethylphenoxy)pyridine-3-car- boxamide (Compound 341), N-[(6-amino-2-pyridyl)sulfonyl]-6-(7-fluoro-1,3-benzodioxol-4-yl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 345), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-[(2,4,6-trimethylphenyl)methyl]p- yridine-3-carboxamide (Compound 346), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(3-fluoro-4-methyl-phenyl)pyridi- ne-3-carboxamide (Compound 349), N-(benzenesulfonyl)-6-tert-butyl-3-(2,4,6-trimethylphenoxy)pyridine-2-car- boxamide (Compound 350), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-5-isobutoxy-phenyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 351), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,3-dimethyl-1-piperidyl)-6-(6-isoprop- oxy-3-pyridyl)pyridine-3-carboxamide (Compound 353), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(1-piperidyl)-N-(1H-pyrazol-5-ylsulfony- l)pyridine-3-carboxamide (Compound 355), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(4-ethylphenyl)pyridine-3-carbox- amide (Compound 359), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethylpyrrolidin-1-yl)-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 361), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-tert-butylphenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 364), N-[(2-methoxy-3-pyridyl)sulfonyl]-6-(1-methylcyclopropyl)-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 365), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 368), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(3R,5S)-3,5-dimethyl-1-piperidyl]-6-(3- -fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 371), N-[[6-(2-methoxyethylamino)-2-pyridyl]sulfonyl]-6-methyl-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (compound 372), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[(2S,5R)-2,5-dimethylpyrro- lidin-1-yl]pyridine-3-carboxamide (Compound 373), 6-(2-fluoro-4-methoxy-phenyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 374), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-methoxy-4-methyl-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 375), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-phenoxy- -pyridine-3-carboxamide (Compound 376), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(1-pipe- ridyl)pyridine-3-carboxamide (Compound 380), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylphenoxy)-6-(1-isobutylpyra- zol-4-yl)pyridine-3-carboxamide (Compound 381), 2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6-(3-ethoxy-5-fluoro-phenyl)-N-(1- H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 382), 2-(3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-N-[(6-amino-2-pyr- idyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 383), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(1,3-dimethylbutoxy)-4-pyridyl]-2-(2- ,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 384), methyl (2S)-1-[3-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-(3-fluoro-5-iso- butoxy-phenyl)-2-pyridyl]pyrrolidine-2-carboxylate (Compound 385), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-methylindol-4-yl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 386), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-fluoro-2-methoxy-3-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 387), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(cyanomethyl)phenyl]-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 388), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(4-isobutoxy-2-pyridyl)pyridine-3-carboxamide (Compound 389), N-[(6-amino-2-pyridyl)sulfonyl]-5-bromo-2-[(2S,5R)-2,5-dimethylpyrrolidin- -1-yl]-6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 390), 6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-N-(1H-pyrazol-3-ylsulfonyl)-- 2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 391), 2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-N-[(2-oxo-1H-pyridin-3-yl)sulfony- l]-6-(p-tolyl)pyridine-3-carboxamide (Compound 392), 2-[(3,3-difluorocyclobutyl)methylamino]-6-(3-fluoro-5-isobutoxy-phenyl)-N- -(1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 393), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-hydroxyphenyl)sulfonyl-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 395), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-2-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 396), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxy-2-pyridyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 397), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2R)-2- -(trifluoromethyl)pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 398), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,4-dimethylphenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 399), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(5-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 400), 6-tert-butyl-N-(1H-pyrazol-4-ylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 401), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isopropoxy-4-pyridyl)-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 402), 6-(6-isopropoxy-3-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4R)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 403), 6-(4-fluoro-2-methoxy-phenyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 405), 6-tert-butyl-2-(p-tolyl)-N-(2-pyridylsulfonyl)pyridine-3-carboxamide (Compound 407), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3R)-3- -methyl-1-piperidyl]pyridine-3-carboxamide (Compound 408), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxyphenyl)-2-(p-tolyl)pyridine-3-- carboxamide (Compound 409), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-cyclohexyl-pyridine-3-carb- oxamide (Compound 411), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[isobutyl(methyl)aminol-3-pyridyl]-2- -(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 412), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-methoxyphenyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 413), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(4-isopropylphenyl)-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 414), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(3-fluoro-5-isobutoxy-phenyl)-N- -(1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 415), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,5-dimethylcyclopentoxy)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 416), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(4-fluorophenyl)pyridine-3- -carboxamide (Compound 417), N-[(6-amino-2-pyridyl)sulfonyl]-2-(azepan-1-yl)-6-(3-fluoro-5-isobutoxy-p- henyl)pyridine-3-carboxamide (Compound 418), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[3-(met- hoxymethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 419), N-[(6-amino-2-pyridyl)sulfonyl]-2-(7-azabicyclo[2.2.1]heptan-7-yl)-6-(3-f- luoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 420), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2S)-2- -methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 421), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-methyl-1-piperidyl)-N-[(2-oxo-1H-pyr- idin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 422), = N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(8-oxa-- 4-azaspiro[4.41nonan-4-yl)pyridine-3-carboxamide (Compound 424), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-meth- yl-1-piperidyl)pyridine-3-carboxamide (Compound 425), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-[4-(trifluo- romethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 426), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(cyclobutoxy)-3-pyridyl]-2-[(2S,5R)-- 2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 428), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-propylphenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 429), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4,6-trimethylphenoxy)-6-vinyl-pyridi- ne-3-carboxamide (Compound 430), 2-(3-ethynyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5- -ylsulfonyl)pyridine-3-carboxamide (Compound 431), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isobutoxy-2-pyridyl)pyridine-3-carboxamide (Compound 432), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-tetrahy- drofuran-3-yloxy-pyridine-3-carboxamide (Compound 433), N-(3-aminopyrazin-2-yl)sulfonyl-2-(2,4-dimethylphenoxy)-6-(4-ethoxyphenyl- )pyridine-3-carboxamide (Compound 434), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(3,3,4-trime- thyl-1-piperidyl)pyridine-3-carboxamide (Compound 435), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropoxyphenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 436), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(isopropylamino)-3-pyridyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 437), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-meth- ylcyclohexoxy)pyridine-3-carboxamide (Compound 438), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,4-difluorophenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 439), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isobutoxyphenyl)-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 440), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,3R)-2,3-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 441), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-methyl-1-piperidyl)-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 442), 6-(4-ethoxyphenyl)-2-(4-methyl-1-piperidyl)-N-(1H-pyrazol-5-ylsulfonyl)py- ridine-3-carboxamide (Compound 445), 2-[(3R,5S)-3,5-dimethyl-1-piperidyl]-6-(6-isopropoxy-3-pyridyl)-N-(1H-pyr- azol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 446), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2R)-2- -phenylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 447), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methoxypyrimidin-5-yl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 449), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-hydroxy-3-methyl-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 450), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methylindazol-4-yl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 451), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-meth- ylcyclopentoxy)pyridine-3-carboxamide (Compound 452), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,5-dihydropyrrol-1-yl)-6-(3-fluoro-5-- isobutoxy-phenyl)pyridine-3-carboxamide (Compound 453), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -[6-[(1-methylcyclopropyl)methoxyl-3-pyridyl]pyridine-3-carboxamide (Compound 454), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxyphenyl)-5-methyl-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 455), N-[(6-amino-2-pyridyl)sulfonyl]-6-(p-tolyl)-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 456), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-methyl-5-(trifluoromethyl)pyrazol-3-- yl]-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 457), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 458), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chlorophenyl)-2-[(2S,5R)-2,5-dimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 459), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[(2,4-dimethyl-3-pyridyl)o- xy]pyridine-3-carboxamide (Compound 460), 6-[[6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,4,6-trimethylphenoxy)pyridine-3-- carbonyl]sulfamoyl]pyridine-2-carboxylic acid (Compound 461), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluorophenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 463), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2,2,3-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 464), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(morpholinomethyl)phenyl]-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 465), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(2-oxopyrrolidin-3-yl)sulfonyl-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 466), 6-tert-butyl-N-[[6-(dimethylamino)-2-pyridyl]sulfonyl]-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 468), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-propylpyrazol-4-yl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 469), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-methoxy-2-methyl-phenyl)-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 470), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxy-3-pyridyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 471), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-benzylpyrrolidin-1-yl)-6-(3-fluoro-5- -isobutoxy-phenyl)pyridine-3-carboxamide (Compound 473), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(1-piperidyl)pyrimidin-5-yl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 475), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(1R,4S)-3-azabicyclo[2.2.1]heptan-3-yl- ]-6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 476), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methoxy-3-methyl-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 477), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(cyclohexen-1-yl)pyridine-- 3-carboxamide (Compound 478), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-meth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 479), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(3- S)-3-phenyl-1-piperidyl]pyridine-3-carboxamide (Compound 481), N-[[6-(isopropylamino)-2-pyridyl]sulfonyl]-6-methyl-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 482), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-fluoro-5-isobutoxy-phenyl)-5-methyl-pyridine-3-carboxamide (Compound 483), 6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-N-[[6-(1-piperidyl)-2-pyrid- yl]sulfonyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 484), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,3-dimethoxyphenyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 485), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-3-pyridyl)-5-methyl-pyridine-3-carboxamide (Compound 486), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(3-fluoro-5-isopropoxy-phenyl)-- N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 487), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-meth- yl-4-phenyl-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 488), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[3-(2-pyridy- l)-1-piperidyl]pyridine-3-carboxamide (Compound 489), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[4-(tri- fluoromethyl)-3-azabicyclo[3.1.01hexan-3-yl]pyridine-3-carboxamide (Compound 490), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-propoxy-4-pyridyl)-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 491), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 492), N-[(6-amino-2-pyridyl)sulfonyl]-2-[2-(1,1-dimethylpropyl)pyrrolidin-1-yl]- -6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 493), 6-(4-isopropoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 494), N-[(6-amino-2-pyridyl)sulfonyl]-6-[5-(cyclopentoxy)-3-pyridyl]-2-[(2S,5R)- -2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 495), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,5-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 496), 6-(6-isopropoxy-3-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 497), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-isopropyl-1-piperidyl)-N-(1H-pyrazol- -5-ylsulfonyl)pyridine-3-carboxamide (Compound 498), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,4-dimethoxypyrimidin-5-yl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 499), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclopropylmethyl(propyl)aminol-6-(6-i- sopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 500), 6-tert-butyl-N-[[6-(difluoromethyl)-2-pyridyl]sulfonyl]-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 501), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2-methyl-4-- phenyl-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 502), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,3-dimethylcyclopentoxy)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 503), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-isopropoxy-phenyl)-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 504), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-hydroxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 505), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-spiro[1H-is- obenzofuran-3,4'-piperidine]-1'-yl-pyridine-3-carboxamide (Compound 506), N-(3-aminopyrazin-2-yl)sulfonyl-6-(4-ethoxyphenyl)-2-(4-methyl-1-piperidy- l)pyridine-3-carboxamide (Compound 507), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2-phenylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 509), 2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-methoxy- phenyl)sulfonyl-pyridine-3-carboxamide (Compound 510), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(3-isobutoxyphenyl)-N-[(2-oxo-1- H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 511), 6-tert-butyl-N-[(6-methoxy-3-pyridyl)sulfonyl]-2-(p-tolyl)pyridine-3-carb- oxamide (Compound 512), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-methyl-3-pyridyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 513), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-4-pyridyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 514), N-[amino-(6-amino-2-pyridyl)-oxo-.lamda..sup.6-sulfanylidene]-6-tert-buty- l-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 515) N-[(6-amino-2-pyridyl)sulfonyl]-2-[1-cyclopropylethyl(methyl)aminol-6-(3-- fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 516), 2-(2,4-dimethylphenoxy)-6-(4-ethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulf- onyl]pyridine-3-carboxamide (Compound 517), 6-(4-fluorophenyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 518), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-oxa-8-azaspiro[3.51nonan-8-yl)-N-(1H- -pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 519), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(3,3,5-trime- thyl-1-piperidyl)pyridine-3-carboxamide (Compound 520), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-azabicyclo[2.2.1]heptan-3-yl)-6-(6-i- sopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 521), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(3-propyl-1-- piperidyl)pyridine-3-carboxamide (Compound 522), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(isobutylamino)-4-pyridyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 523), N-[(2-methoxy-3-pyridyl)sulfonyl]-2,6-bis(p-tolyl)pyridine-3-carboxamide (Compound 524), 6-(1,3-benzodioxol-4-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 525), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methoxy-3-pyridyl)-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 526), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6-azaspiro[3.31heptan-6-yl)-6-(3-fluor- o-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 527), 2-(3,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazo- l-5-ylsulfonyl)pyridine-3-carboxamide (Compound 528), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(cyclopenten-1-yl)pyridine- -3-carboxamide (Compound 529), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-ethyl-3-methyl-1-piperidyl)-6-(3-flu- oro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 530), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-methoxy-3-pyridyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 531), N-[(6-amino-2-pyridyl)sulfonyl]-6-methyl-2-[(3S)-3-phenyl-1-piperidyl]pyr- idine-3-carboxamide (Compound 532), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylphenoxy)-6-(6-methoxy-5-me- thyl-3-pyridyl)pyridine-3-carboxamide (Compound 533), 6-(6-isopropoxy-3-pyridyl)-2-(4-methyl-1-piperidyl)-N-(1H-pyrazol-5-ylsul- fonyl)pyridine-3-carboxamide (Compound 534), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-propoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 535), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxy-2-methyl-phenyl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 536), N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-cyclohexyl-pyridine-3-carboxamid- e (Compound 537), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4,4-dimethylcyclohexyl)-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 538), 6-[3-(cyclopropylmethoxy)-5-fluoro-phenyl]-2-[(2S,5R)-2,5-dimethylpyrroli- din-1-yl]-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 541), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-phenyl-pyridine-3-carboxamide (Compound 542), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-fluoro-4-(isopropylcarbamoyl)phenyl]- -2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 543), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isobutoxy-3-pyridyl)pyridine-3-carboxamide (Compound 544), 6-(2,5-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 545), 6-(3,4-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 546), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3S)-2- ,2,3-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 547), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)phenyl]-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 548), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-indol-4-ylsulfonyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 549), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(4-methoxyphenyl)pyridine-3-carb- oxamide (Compound 550), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-ethoxy-5-fluoro-phenyl)pyridine-3-carboxamide (Compound 551), 6-(2-fluoro-5-propoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 552), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-isopropyl-1-piperidyl)-N-(1H-pyrazol- -5-ylsulfonyl)pyridine-3-carboxamide (Compound 553), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 555), 2-[4-(cyanomethyl)-1-piperidyl]-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyr- azol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 556), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(3S)-2,2,3-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 557), N-[(6-amino-2-pyridyl)sulfonyl]-2-[3-(3,4-difluorophenyl)-1-piperidyl]-6-- (6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 558), N-(3-aminopyrazin-2-yl)sulfonyl-2-(2,4-dimethylphenoxy)-6-(3-fluoro-5-iso- propoxy-phenyl)pyridine-3-carboxamide (Compound 559), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3,3,5-- trimethyl-1-piperidyl)pyridine-3-carboxamide (Compound 560), 6-(4-fluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 561), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[1-(3-f- luorophenyl)ethoxy]pyridine-3-carboxamide (Compound 562), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(4-isobutoxyphenyl)pyridine-3-carboxamide (Compound 563), N-[(6-amino-2-pyridyl)sulfonyl]-6-pyrazol-1-vi-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 564), 2-(3,3-difluoropyrrolidin-1-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyr- azol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 565), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(1-piperidyl- )pyridine-3-carboxamide (Compound 567), N--[S-(3-aminophenyl)-N-methyl-sulfonimidoyl]-6-tert-butyl-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 568), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(isobutylamino)-3-pyridyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 569), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluorophenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 570), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(1-piperidyl)pyridine-3-ca- rboxamide (Compound 571), 6-[3-(2,2-dimethylpropoxy)-5-fluoro-phenyl-2-[(2S,5R)-2,5-dimethylpyrroli- din-1-yl]-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 572), 6-(4,4-dimethylcyclohexen-1-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 573), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[2-(methoxym- ethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 574), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3,3,4-- trimethyl-1-piperidyl)pyridine-3-carboxamide (Compound 575), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[(1R)-2-benzyloxy-1-methyl-ethoxyl-3- -pyridyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 576), 6-(1-isobutylpyrazol-4-yl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 577), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6-azaspiro[2.5]octan-6-yl)-6-(6-isopro- poxy-3-pyridyl)pyridine-3-carboxamide (Compound 578), 6-(4-chlorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 579), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(1-ethylpropoxy)-2-pyridyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 580), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(1R,5S)-3-azabicyclo[3.2.1]octan-3-yl]- -6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 581), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(trifluoromethyl)-1H-pyrazol-4-yl]-2- -(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 582), N-(benzenesulfonyl)-2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-- phenyl)pyridine-3-carboxamide (Compound 583), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,5-dimethylpyrazol-4-yl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 584), 6-(3-ethoxy-5-fluoro-phenyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 585), N-(6-aminopyrazin-2-yl)sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 586), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylpyrrolidin-1-yl)-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 587), N-[(6-amino-2-pyridyl)sulfonyl]-2-indolin-1-vi-6-(6-isopropoxy-3-pyridyl)- pyridine-3-carboxamide (Compound 588), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(4-isopropylphenyl)-N-[(2-oxo-1- H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 589), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylphenoxy)-6-(3-fluoro-5-iso- butoxy-phenyl)pyridine-3-carboxamide (Compound 590), 2-(2-ethylpyrrolidin-1-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-- 5-ylsulfonyl)pyridine-3-carboxamide (Compound 591), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-pyrroli- din-1-yl-pyridine-3-carboxamide (Compound 592), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-cyclopropylpyrrolidin-1-yl)-6-(3-flu- oro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 593), N-[[6-(cyclopropylamino)-2-pyridyl]sulfonyl]-6-methyl-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 594), N-[[6-(2-hydroxyethylamino)-2-pyridyl]sulfonyl]-6-phenyl-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 595), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6,6-dimethyl-3-azabicyclo[3.1.0]hexan-- 3-yl)-6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 596), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-tert-butylpyrrolidin-1-yl)-6-(6-isop- ropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 597), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-ethoxy-2-fluoro-phenyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 599), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isopropoxy-phenyl)-2-(4-met- hyl-1-piperidyl)pyridine-3-carboxamide (Compound 600), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,5-dimethyl-3-phenyl-pyrrolidin-1-yl)- -6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 601), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxy-2-fluoro-phenyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 602), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4- R)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 605), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[4-(methoxym- ethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 606), N-(3-aminopyrazin-2-yl)sulfonyl-2-(2,4-dimethylphenoxy)-6-(p-tolyl)pyridi- ne-3-carboxamide (Compound 607), 6-(4-fluoro-2-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 608), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6,6-dimethyl-3-azabicyclo[3.1.0]hexan-- 3-yl)-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 609), 2-(2,4-dimethylphenoxy)-6-(p-tolyl)-N-(1H-pyrazol-3-ylsulfonyl)pyri- dine-3-carboxamide (Compound 610), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-tert-butylpyrrolidin-1-yl)-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 611), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-fluoro-6-methoxy-3-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 612), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-tert-butylpyrrolidin-1-yl)-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 613), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,4-dimethylphenyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 614), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-ethyl-1-piperidyl)-6-(3-fluoro-5-iso- butoxy-phenyl)pyridine-3-carboxamide (Compound 615), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxy-2-methyl-3-pyridyl)-2-(2,2- ,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 616), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(3,5-dimethyl-1-piperidyl)- pyridine-3-carboxamide (Compound 617), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(3-ethyloxetan-3-yl)methoxyl-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 618), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-ethyl-1-piperidyl)-6-(6-isopropoxy-3- -pyridyl)pyridine-3-carboxamide (Compound 619), N-(benzenesulfonyl)-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 620), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-(trifluoromethyl)cyclopropyl]-2-(2,4- ,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 621), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-fluoro-2-hydroxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 622), 6-tert-butyl-N-(2-cyanophenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamide (Compound 623), 6-(4-fluoro-3-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 624), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2-methyl-3-- phenyl-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 625), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[(3R)-3-phenyl-1-piperidyl- ]pyridine-3-carboxamide (Compound 626), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,6-dimethoxy-4-methyl-phenyl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 629), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropylphenyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 630), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-isobutylpyrazol-4-yl)-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 631), 6-tert-butyl-2-(p-tolyl)-N-(1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamid- e (Compound 632), N-[(6-amino-2-pyridyl)sulfonyl]-6-[5-methyl-3-(trifluoromethyl)pyrazol-1-- yl]-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 633), N-[(2-amino-3-pyridyl)sulfonyl]-6-tert-butyl-2-(p-tolyl)pyridine-3-carbox- amide (Compound 636), N-[(6-amino-2-pyridyl)sulfonyl]-6-ethoxy-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 637), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(cyanomethyl)phenyl]-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 638), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,6-dimethylphenoxy)-6-(3-fluoro-5-iso- butoxy-phenyl)pyridine-3-carboxamide (Compound 639), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(oxetan- -2-ylmethoxy)pyridine-3-carboxamide (Compound 640), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylphenoxy)-6-(4-ethoxyphenyl- )pyridine-3-carboxamide (Compound 641), 2-[(3R,5S)-3,5-dimethyl-1-piperidyl]-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1- H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 642), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-pyridyl)-2-(2,2,4-trimethylpyrrolidi- n-1-yl)pyridine-3-carboxamide (Compound 643), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-propoxy-phenyl)-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 644), 6-(3-fluoro-5-isopropoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2- ,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 645), 6-methyl-N-[[6-(methylamino)-2-pyridyl]sulfonyl]-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 646), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-benzylpyrrolidin-1-yl)-6-(6-isopropo- xy-3-pyridyl)pyridine-3-carboxamide (Compound 647), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(cyclohexoxy)pyridine-3-ca- rboxamide (Compound 649), N-[(6-amino-2-pyridyl)sulfonyl]-6-(isopropylamino)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 650), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3R)-3- -phenyl-1-piperidyl]pyridine-3-carboxamide (Compound 651), 6-(3-fluoro-5-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 652), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-phenyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 654), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-cyclopropyl-1-piperidyl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 655), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[3-(2,2,2-tr- ifluoroethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 656), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3R)-2- ,2,3-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 657), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-benzyl-2-methyl-pyrrolidin-1-yl)-6-(- 6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 658), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[2-(2-p- yridyl)pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 659), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-N-[(2-oxo-1H-pyridin-3-yl)sulfony- l]-6-phenyl-pyridine-3-carboxamide (Compound 660), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-3-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 661), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-benzyl-2-methyl-pyrrolidin-1-yl)-6-(- 3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 663), 6-[3-(cyclopropylmethoxy)-5-fluoro-phenyl]-2-(4-methyl-1-piperidyl)-N-[(2- -oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 664), 6-tert-butyl-N-[(1-methyl-2-oxo-3-pyridyl)sulfonyl]-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 667), 6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3R)-3-methyl-1-piperidyl]-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 668), 6-methyl-N-(1H-pyrazol-5-ylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridine-3- -carboxamide (Compound 670), 2-(2,6-dimethylphenoxy)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-y- lsulfonyl)pyridine-3-carboxamide (Compound 671), N-[(6-amino-2-pyridyl)sulfonyl]-6-(m-tolyl)-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 672), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2- ,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 673), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2-methyl-2,- 3,3a,4,5,6,7,7a-octahydroindol-1-yl)pyridine-3-carboxamide (Compound 675), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(trifluoromethyl)pyrazol-1-yl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 676), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-[3-(2-pyrid- yl)-1-piperidyl]pyridine-3-carboxamide (Compound 677), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3S)-3- -methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 678), 6-(3-fluoro-5-isobutoxy-phenyl)-2-phenoxy-N-(1H-pyrazol-5-ylsulfonyl)pyri- dine-3-carboxamide (Compound 679), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-azabicyclo[2.2.1]heptan-3-yl)-6-(3-f- luoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 680), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(2-fluoro-5-isobutoxy-phenyl)-N- -(1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 681), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 682), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclobutyl(methyl)aminol-6-(3-fluoro-5- -isobutoxy-phenyl)pyridine-3-carboxamide (Compound 683), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3S)-3- -phenyl-1-piperidyl]pyridine-3-carboxamide (Compound 684), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(1-piperidylmethyl)phenyl]-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 686), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 687), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(3-fluoro-5-isopentyloxy-phenyl- )-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 688), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylpyrrolidin-1-yl)-6-(- 6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 689), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)pyrazol-1-yl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 691), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-propoxy-phenyl)-2-(4-methyl- -1-piperidyl)pyridine-3-carboxamide (Compound 692), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropylphenyl)-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 693), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2R)-2- -methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 694), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutoxyphenyl)-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 695), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(2,2,2-trifluoroethoxy)-3-pyridyl]-2- -(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 697), N-[(6-fluoro-2-pyridyl)sulfonyl]-6-phenyl-2-(2,4,6-trimethylphenoxy)pyrid- ine-3-carboxamide (Compound 698), N-(3-aminopyrazin-2-yl)sulfonyl-6-(3-fluoro-5-isopropoxy-phenyl)-2-(4-met- hyl-1-piperidyl)pyridine-3-carboxamide (Compound 699), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-fluoro-2-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 700), 6-(4-chloro-3-isopropoxy-phenyl)-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-- N-(1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 701), N-[(6-amino-3-pyridyl)sulfonyl]-6-tert-butyl-2-(p-tolyl)pyridine-3-carbox- amide (Compound 702), N-[(6-amino-2-pyridyl)sulfonyl]-2-(7-azaspiro[2.5]octan-7-yl)-6-(6-isopro- poxy-3-pyridyl)pyridine-3-carboxamide (Compound 703), N-[(6-amino-2-pyridyl)sulfonyl]-6-cyclohexyl-2-[(2S,5R)-2,5-dimethylpyrro- lidin-1-yl]pyridine-3-carboxamide (Compound 704), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-methoxy-5-methyl-3-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 705), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-tetrahy- dropyran-3-yloxy-pyridine-3-carboxamide (Compound 706), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-2-pyridyl)-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 708), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(trifluoromethyl)phenyl]-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 709), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(3-isobutoxyphenyl)-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 710), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,5-dimethyl-3-phenyl-pyrrolidin-1-yl)- -6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 711), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-fluorophenyl)-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 712), N-(3-aminopyrazin-2-yl)sulfonyl-2-(2,4-dimethylphenoxy)-6-(1-isobutylpyra- zol-4-yl)pyridine-3-carboxamide (Compound 713), 6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2S)-2-phenylpyrrolidin-1-yl]-N-(1H-py- razol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 716), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(1,2-dimethylpropoxy)-2-pyridyl]-2-(- 2,2-dimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 717), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-ethoxy-3-pyridyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 718), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2S)-2- -(methoxymethyl)pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 719), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,3-dimethylpyrrolidin-1-yl)-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 720), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(2-fluoro-5-isobutoxy-phenyl)-N- -[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 721), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isopropoxy-phenyl)-2-(p-tol- yl)pyridine-3-carboxamide (Compound 722), methyl 2-[[5-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-[(2S,5R)-2,5-dimethylpy- rrolidin-1-yl]-2-pyridyl]-2-pyridyl]oxy]propanoate (Compound 723), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2-isopropyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 724), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,4-difluorophenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 725), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-methoxy-3-pyridyl)pyridine-3-carboxamide (Compound 726), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-fluoro-5-(hydroxymethyl)phenyl]-2-(2- ,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 727), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-fluoro-1-piperidyl)-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 728), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(3-oxa-7-aza- spiro[3.51nonan-7-yl)pyridine-3-carboxamide (Compound 729), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-methyl-2-pyridyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 730), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2-phenyl-1-- piperidyl)pyridine-3-carboxamide (Compound 731), 2-(3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-N-[(6-amino-2-pyr- idyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 732), N-[(6-amino-2-pyridyl)sulfonyl]-2-(7-azaspiro[3.51nonan-7-yl)-6-(6-- isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 733), 2-(azepan-1-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfony- l)pyridine-3-carboxamide (Compound 734), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-meth- yl-1-piperidyl)pyridine-3-carboxamide (Compound 735), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(4-methyl-1-- piperidyl)pyridine-3-carboxamide (Compound 736), 6-(3-fluoro-5-isopropoxy-phenyl)-2-(4-methyl-1-piperidyl)-N-[(2-oxo-1H-py- ridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 737), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-methylphenoxy)-N-(1H-pyrazol-5-ylsul- fonyl)pyridine-3-carboxamide (Compound 738), 6-(3-fluoro-5-isobutoxy-phenyl)-2-indolin-1-yl-N-(1H-pyrazol-5-ylsulfonyl- )pyridine-3-carboxamide (Compound 739), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclopropylmethyl(methyl)aminol-6-(6-i- sopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 740), 6-(6-isopropoxy-3-pyridyl)-2-[(3R)-3-phenyl-1-piperidyl]-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 741), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(4-phenyl-1-- piperidyl)pyridine-3-carboxamide (Compound 742), 6-(4-methylcyclohexyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 743), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-fluoro-1-piperidyl)-6-(6-isopropoxy-- 3-pyridyl)pyridine-3-carboxamide (Compound 745), N-[(6-amino-2-pyridyl)sulfonyl]-6-pyrrolidin-1-vi-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 746), N-[(6-amino-2-pyridyl)sulfonyl]-6-tetrahydropyran-4-v-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 748), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-methoxy-1-piperidyl)-N-(1H-pyrazol-5- -ylsulfonyl)pyridine-3-carboxamide (Compound 749), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 751), N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-[(4-methyltetrahydropyran-4-yl)m- ethylamino]pyridine-3-carboxamide (Compound 752), N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-(1-piperidyl)pyridine-3-carboxam- ide (Compound 753), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,6-dimethoxy-3-pyridyl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 754), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-methyl-1-piperidyl)-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 756), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(3R)-3-meth- yl-1-piperidyl]pyridine-3-carboxamide (Compound 757), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-methylphenoxy)-N-(1H-pyrazol-5-ylsul- fonyl)pyridine-3-carboxamide (Compound 758), 6-(4-chlorophenyl)-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-N-[(2-oxo-1H-p- yridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 760), N-[(6-amino-2-pyridyl)sulfonyl]-6-(o-tolyl)-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 761), 6-(2-fluoro-5-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 762), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-fluorophenyl)-5-methyl-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 763), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,3S)-2,3-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 764), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(1-phenyleth- ylamino)pyridine-3-carboxamide (Compound 766), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2-cyano-4,6-dimethyl-phen- oxy)pyridine-3-carboxamide (Compound 767), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-hydroxy-3-methoxy-phenyl)-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 768), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2,2-difluorocyclopropyl)methoxyl-6-(3- -fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 769), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(6-isopropoxy-3-pyridyl)-N-[(2-- oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 770), N-[(6-cyano-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 771), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-benzylpyrrolidin-1-yl)-6-(3-fluoro-5- -isobutoxy-phenyl)pyridine-3-carboxamide (Compound 772), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-propoxy-phenyl)-2-[(2R,5S)-- 2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 773), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-methoxy-4-methyl-1-piperidyl)-N-(1H-- pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 774), 2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-[(6-oxo-1H- -pyridin-2-yl)sulfonyl]pyridine-3-carboxamide (Compound 775), 6-(6-isopropoxy-3-pyridyl)-2-[(3S)-3-phenyl-1-piperidyl]-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 776), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutoxyphenyl)-2-(4-methyl-1-piper- idyl)pyridine-3-carboxamide (Compound 777), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-meth- ylphenoxy)pyridine-3-carboxamide (Compound 778), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)pyrazin-2-yl]-2- -(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 779), N-[(6-amino-2-pyridyl)sulfonyl]-2-[2,2-dimethyl-3-(trifluoromethyl)pyrrol- idin-1-yl]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 780), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(6-methoxy-2-pyridyl)-N-[- (2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 781), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[1-(o-t- olyl)ethoxy]pyridine-3-carboxamide (Compound 782), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4,4-difluorocyclohexyl)-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 783), 6-phenyl-N-(1H-pyrazol-5-ylsulfonyl)-2-(2,4,6-trimethylphenoxy)pyridine-3- -carboxamide (Compound 784), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-piperidyl)-2-(2,4,6-trimethylphenoxy- )pyridine-3-carboxamide (Compound 785), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(hydroxymethyl)phenyl]-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 786), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(dimethylamino)-3-pyridyl]-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 787), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-isopropoxy-phenyl)-2-[(2S,5- R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 788), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(cyclopropylmethoxy)-3-pyridyl]-2-[(- 2S,5R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 789), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-methoxypropyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 791), N-[[6-(2-aminoethylamino)-2-pyridyl]sulfonyl]-6-methyl-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 792), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-hydroxy-4-methyl-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 793), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(4-methyl-1-piperidyl)pyri- dine-3-carboxamide (Compound 794), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(diethylamino)-3-pyridyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 796), 6-(3-fluoro-5-isopropoxy-phenyl)-N-[(2-methoxy-3-pyridyl)sulfonyl]-2-(p-t- olyl)pyridine-3-carboxamide (Compound 798), 6-[3-(aminomethyl)phenyl]-N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 801), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-methyl-1-piperidyl)-6-(p-tolyl)pyrid- ine-3-carboxamide (Compound 802), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,5-difluorophenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 803), 6-(2-fluoro-3-isobutoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 804), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -phenyl-pyridine-3-carboxamide (Compound 805), N-[(6-amino-2-pyridyl)sulfonyl]-6-methoxy-2-(2,4,6-trimethylphenoxy)pyrid- ine-3-carboxamide (Compound 806), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(2-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 807), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-isopropylpyrazol-4-yl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 808), 6-tert-butyl-N-(4-hydroxyphenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamid- e (Compound 809), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(morpholinomethyl)phenyl]-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 810), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 811), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-- yl]-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 812), 2-(2,4-dimethylphenoxy)-6-(4-ethoxyphenyl)-N-(1H-pyrazol-3-ylsulfonyl)pyr- idine-3-carboxamide (Compound 813), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-2-methyl-3-pyridyl)-2-(2,- 2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 814), 6-(3,5-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 815), N-[(6-amino-2-pyridyl)sulfonyl]-5-(o-tolyl)-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 817), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-spiro 1H-isobenzofuran-3,4'-piperidine]-1'-yl-pyridine-3-carboxamide (Compound 818), N-(3-aminopyrazin-2-yl)sulfonyl-6-(4-ethoxyphenyl)-2-(p-tolyl)pyrid- ine-3-carboxamide (Compound 819), N-(3-aminopyrazin-2-yl)sulfonyl-2,6-bis(p-tolyl)pyridine-3-carboxamide (Compound 820), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-fluoro-2-methyl-phenyl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 822), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3-met- hyloxetan-3-yl)methoxy]pyridine-3-carboxamide (Compound 824), N-(3-aminophenyl)sulfonyl-6-(1-methylcyclopropyl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 826), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[isobutyl(methyl)aminol-2-methyl-3-p- yridyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 827), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,5-dimethoxyphenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 828), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2,4-difluorophenoxy)pyrid- ine-3-carboxamide (Compound 829), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-fluoro-2-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 830), 6-(4-ethylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 831), 6-(4-chloro-3-propoxy-phenyl)-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl-N-(1- H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 832), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-methoxyphenyl)-5-methyl-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 833), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethylpyrrolidin-1-yl)-6-(6-isop- ropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 834), 6-(3-ethoxy-5-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 835), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(3S)-3-meth- yl-1-piperidyl]pyridine-3-carboxamide (Compound 836), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,3-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 837), 6-(2-fluoro-4-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 839), N-[(6-amino-2-pyridyl)sulfonyl]-5,6-dimethyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 841), N-(4-aminothiazol-2-yl)sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 842) 2-(3-ethoxy-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 843), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isopropoxypyrimidin-5-yl)-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 844), N-[(6-amino-2-pyridyl)sulfonyl]-2-(8-azaspiro[3.4]octan-8-yl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 845), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(1,3-dimethylbutoxy)-2-pyridyl]-2-(2- ,2-dimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 846), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropylphenyl)-2-(4-methyl-1-piper- idyl)pyridine-3-carboxamide (Compound 847), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopentyloxy-3-pyridyl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 848), 6-(3-fluoro-5-isopropoxy-phenyl)-2-(p-tolyl)-N-(1H-pyrazol-5-ylsulfonyl)p- yridine-3-carboxamide (Compound 849), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4,- 4-tetramethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 850), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxy-4-methyl-3-pyridyl)-2-(2,2- ,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 851), N-[(6-amino-2-pyridyl)sulfonyl]-6-chloro-2-[(4S)-2,2,4-trimethylpyrrolidi- n-1-yl]pyridine-3-carboxamide (Compound 852), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,1,2,2,2-pentafluoroethyl)-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 853), N-[(6-amino-2-pyridyl)sulfonyl]-5-(1-methylcyclopropyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 854), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1H-indazol-5-yl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 856), 2-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-N-[(6-amino-2-pyr- idyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 857), N-[(6-amino-2-pyridyl)sulfonyl]-2-[3-(cyclopropylmethoxy)-1-piperidyl]-6-- (6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 858), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-phen- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 859), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-ethoxy-4-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 860), 6-(6-methoxy-5-methyl-3-pyridyl)-N-[(2-methoxy-3-pyridyl)sulfonyl]-2-(p-t- olyl)pyridine-3-carboxamide (Compound 861), N-[(6-amino-2-pyridyl)sulfonyl]-6-pentyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 862), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-methoxy-5-methyl-3-pyridyl)-2-(4-met- hyl-1-piperidyl)pyridine-3-carboxamide (Compound 863), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(3S)-3-phen- yl-1-piperidyl]pyridine-3-carboxamide (Compound 864), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-isopropylphenyl)-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 865), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-2-hydroxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 866), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[1-(4-f- luorophenyl)ethoxy]pyridine-3-carboxamide (Compound 867), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-tert-butylphenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 868), N-[[6-(dimethylamino)-2-pyridyl]sulfonyl]-6-phenyl-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 869), N-[[6-(aminomethyl)-2-pyridyl]sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2- -(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 871), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(oxetan- -3-yloxy)pyridine-3-carboxamide (Compound 872), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(1-phen- ylethoxy)pyridine-3-carboxamide (Compound 874), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-4-methyl-phenyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 875), 6-(2-chlorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 877), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-fluoro-1-piperidyl)-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 878), 2-[(4-methyltetrahydropyran-4-yl)methylamino]-6-(p-tolyl)-N-(1H-pyrazol-3- -ylsulfonyl)pyridine-3-carboxamide (Compound 879) N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-(cyclohexen-1-yl)pyridine-3-carb- oxamide (Compound 880), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclopropylmethyl(propyl)aminol-6-(3-f- luoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 881), 6-(cyclohexen-1-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 882), 6-methyl-N-[(6-morpholino-2-pyridyl)sulfonyl]-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 883), N-[(6-amino-2-pyridyl)sulfonyl]-2-[4-(cyclopropylmethoxy)-1-piperidyl]-6-- (6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 884), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-cyanophenyl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 886), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,3-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 887), 6-(2,5-dimethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 888), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4,4-difluoro-1-piperidyl)-6-(6-isoprop- oxy-3-pyridyl)pyridine-3-carboxamide (Compound 889), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropylphenyl)-2-[(4R)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 890), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(4-isobutoxyphenyl)-N-[(2-oxo-1- H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 891), 2-(2,4-dimethylphenoxy)-6-(6-methoxy-5-methyl-3-pyridyl)-N-(1H-pyrazol-3-- ylsulfonyl)pyridine-3-carboxamide (Compound 892), N-(3-aminopyrazin-2-yl)sulfonyl-2-(2,4-dimethylphenoxy)-6-(6-methoxy-5-me- thyl-3-pyridyl)pyridine-3-carboxamide (Compound 893), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2,2-dimethylcyclopropyl)methoxyl-6-(3- -fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 894), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropyl-3-pyridyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 896), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-2-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 897) N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-[isobutyl(methyl)aminol-4-pyridyl]-2- -(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 898), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethylphenyl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 900), 6-(4-ethoxy-3-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 901), 6-(4-chloro-3-isobutoxy-phenyl)-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-N- -[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 902), N-[(6-amino-2-pyridyl)sulfonyl]-2-(7-azabicyclo[2.2.1]heptan-7-yl)-6-(6-i- sopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 903), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 904), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-4-methyl-3-pyridyl)-2-(2,- 2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 905), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-azabicyclo[3.1.0]hexan-4-yl)-6-(3-fl- uoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 906), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-[3-(trifluo- romethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 907), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-hydroxyphenyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 908), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isopropoxy-3-pyridyl)-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 909), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxyphenyl)-2-(4-methyl-1-piperidy- l)pyridine-3-carboxamide (Compound 910), 6-tert-butyl-N-(2-methylpyrazol-3-yl)sulfonyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 911), 6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3S)-3-phenyl-1-piperidyl]-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 912), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-fluoro-1-piperidyl)-6-(6-isopropoxy-- 3-pyridyl)pyridine-3-carboxamide (Compound 913), 6-(3-fluoro-5-isopropoxy-phenyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 914), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2,2,4,4-tet- ramethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 915), 6-tert-butyl-N-[[6-(2-hydroxyethylamino)-2-pyridyl]sulfonyl]-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 916), 6-(3-ethoxy-4-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 917), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-fluoro-3-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 919), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-6-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 920), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(1S,4R)-3-azabicyclo[2.2.1]heptan-3-yl- ]-6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 921), 6-[3-(cyclobutylmethoxy)-5-fluoro-phenyl]-2-[(2S,5R)-2,5-dimethylpyrrolid- in-1-yl]-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 922), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-cyano-3-methoxy-phenyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 923), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(1S,4R)-3-azabicyclo[2.2.1]heptan-3-yl- ]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 924), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2,3,5-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 925), N-[(6-amino-2-pyridyl)sulfonyl]-2-(9-azaspiro[4.41nonan-9-yl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 926), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-cyclopropylpyrrolidin-1-yl)-6-(6-iso- propoxy-3-pyridyl)pyridine-3-carboxamide (Compound 928), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-ethoxyethyl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 929), 6-(6-methoxy-5-methyl-3-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2- ,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 930), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-ethylpyrrolidin-1-yl)-6-(3-fluoro-5-- isobutoxy-phenyl)pyridine-3-carboxamide (Compound 931), 6-(6-ethoxy-3-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 932), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(tetrah- ydropyran-4-ylmethoxy)pyridine-3-carboxamide (Compound 933), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(1R,5S)-8-azabicyclo[3.2.1]octan-8-yl]- -6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 934), N-[(6-amino-2-pyridyl)sulfonyl]-2-(indan-1-ylamino)-6-(6-isopropoxy-3-pyr- idyl)pyridine-3-carboxamide (Compound 935), 6-(1-methylindol-6-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 936), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,4-dihydro-2H-pyran-6-yl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 937), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,5-dimethylpyrazol-3-yl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 938), N-[(2-methoxy-3-pyridyl)sulfonyl]-6-phenyl-2-(2,4,6-trimethylphenoxy)pyri- dine-3-carboxamide (Compound 939), N-[(6-amino-2-pyridyl)sulfonyl]-2-(azepan-1-yl)-6-(6-isopropoxy-3-pyridyl- )pyridine-3-carboxamide (Compound 940), 6-(4-chloro-3-isobutoxy-phenyl)-2-(4-methyl-1-piperidyl)-N-[(2-oxo-1H-pyr- idin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 941), 2-[(3R,5R)-3,5-dimethyl-1-piperidyl]-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1- H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 942), 2-(7-azaspiro[3.51nonan-7-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 944), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-ethylphenyl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 945), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]py- ridine-3-carboxamide (Compound 946), 6-tert-butyl-N-[[6-(2-dimethylaminoethylamino)-2-pyridyl]sulfonyl]-2-(2,4- ,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 947), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(4R)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 949), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,4-dimethoxyphenyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 950), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(isopropylamino)-2-pyridyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 951), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-(2,3,3-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 952), N-[(6-amino-2-pyridyl)sulfonyl]-2-(7-azaspiro[2.5]octan-7-yl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 953), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-ethynyl-1-piperidyl)-6-(6-isopropoxy- -3-pyridyl)pyridine-3-carboxamide (Compound 954), 6-(2-chloro-3-propoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 955), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-4-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 956), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-isobutoxyphenyl)pyridine-3-carboxamide (Compound 957), 6-(3-isobutoxyphenyl)-2-(4-methyl-1-piperidyl)-N-[(2-oxo-1H-pyridin-3-yl)- sulfonyl]pyridine-3-carboxamide (Compound 958), N-(3-aminophenyl)sulfonyl-6-tert-butyl-4-methoxy-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 959), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-ethoxy-1-piperidyl)-6-(6-isopropoxy-- 3-pyridyl)pyridine-3-carboxamide (Compound 960), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4,4-difluorocyclohexoxy)-6-(3-fluoro-5- -isobutoxy-phenyl)pyridine-3-carboxamide (Compound 961), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(dimethylaminomethyl)phenyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 962), N-[(6-amino-2-pyridyl)sulfonyl]-6-ethyl-2-(2,4,6-trimethylphenoxy)pyridin- e-3-carboxamide (Compound 963), 6-(3-butoxy-2-chloro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 964), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-isopropoxypyrazin-2-yl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 965), N-[(6-amino-2-pyridyl)sulfonyl]-6-morpholino-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 966), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(1-meth- yl-2-phenyl-ethoxy)pyridine-3-carboxamide (Compound 967), N-[(6-amino-2-pyridyl)sulfonyl]-6-isopropoxy-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 968), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-benzyl-2-methyl-pyrrolidin-1-yl)-6-(- 3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 969), N-[(6-amino-2-pyridyl)sulfonyl]-2,6-bis(4-benzoyl-2,6-dimethyl-phenoxy)py- ridine-3-carboxamide (Compound 970), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,3-diethyl-1-piperidyl)-6-(6-isopropo- xy-3-pyridyl)pyridine-3-carboxamide (Compound 971), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isopropoxy-phenyl)-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 972), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6-azaspiro[2.5]octan-6-yl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 973), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,3-benzodioxol-4-yl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 974), 6-(3-fluoro-5-isobutoxy-phenyl)-2-[4-(methoxymethyl)-1-piperidyl]-N-(1H-p- yrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 975), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,6-dihydro-2H-pyran-4-yl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 976), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1H-indol-4-yl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 977), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,6-dimethylcyclohexoxy)-6-(3-fluoro-5- -isobutoxy-phenyl)pyridine-3-carboxamide (Compound 978), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,4-dimethyl-1-piperidyl)-6-(6-isoprop- oxy-3-pyridyl)pyridine-3-carboxamide (Compound 979), 6-(4-methoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 980), 6-(3-fluoro-5-isobutoxy-phenyl)-2-isoindolin-2-yl-N-(1H-pyrazol-5-ylsulfo- nyl)pyridine-3-carboxamide (Compound 981), N-[[6-(3-aminopropylamino)-2-pyridyl]sulfonyl]-6-methyl-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 982), N-[(6-amino-2-pyridyl)sulfonyl]-6-(methylamino)-2-(2,4,6-trimethylphenoxy- )pyridine-3-carboxamide (Compound 983), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,5-difluoro-4-methoxy-phenyl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 984), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[(4S)-2,2,4-trimethylpyrro- lidin-1-yl]pyridine-3-carboxamide (Compound 985), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[4-(methoxymethyl)-1-piper- idyl]pyridine-3-carboxamide (Compound 986), N-[(6-amino-2-pyridyl)sulfonyl]-2-(8-azaspiro[3.4]octan-8-yl)-6-(6-isopro- poxy-3-pyridyl)pyridine-3-carboxamide (Compound 987), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxypyrazin-2-yl)-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 988), N-(3-aminopyrazin-2-yl)sulfonyl-6-(3-fluoro-5-isopropoxy-phenyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 989), 2-[(3R,5R)-3,5-dimethyl-1-piperidyl]-6-(6-isopropoxy-3-pyridyl)-N-(1H-pyr- azol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 990), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-meth- yl-1-piperidyl)pyridine-3-carboxamide (Compound 991), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(3R)-2,2,3-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 992), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-chloro-2-methoxy-3-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 993), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-benzylpyrrolidin-1-yl)-6-(6-isopropo- xy-3-pyridyl)pyridine-3-carboxamide (Compound 994), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-5-methyl-2-(2,- 2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 995), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-propoxyphenyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 996), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-(2,2,3-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 997), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -[6-(2-hydroxy-1-methyl-ethoxy)-3-pyridyl]pyridine-3-carboxamide (Compound 998), 6-(3-chloro-4-propoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2- -(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 999), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-4-methyl-phenyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 1000), 6-(4-chloro-3-isopropoxy-phenyl)-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-- N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 1001), 6-(4-isopropylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 1002), N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-cyclopentyl-pyridine-3-carboxami- de (Compound 1003), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1004), 2-(3,3-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazo- l-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1005), 2-(4,4-difluoro-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazo- l-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1006), 6-[4-(cyclopropylmethoxy)phenyl]-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2- ,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1007), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(3-methyl-1-piperidyl)pyri- dine-3-carboxamide (Compound 1008), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[methyl- -[(1-methylcyclopropyl)methyl]amino]pyridine-3-carboxamide (Compound 1009), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclopropylmethyl(methyl)aminol- -6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1010), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethylpyrrolidin-1-yl)-6-(6-isob- utoxy-2-pyridyl)pyridine-3-carboxamide (Compound 1011), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-benzyloxy-1-piperidyl)-6-(6-isopropo- xy-3-pyridyl)pyridine-3-carboxamide (Compound 1012), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,5-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1013), N-(3-aminophenyl)sulfonyl-2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isob- utoxy-phenyl)pyridine-3-carboxamide (Compound 1014), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylphenoxy)-6-(p-tolyl)pyridi- ne-3-carboxamide (Compound 1015), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isopropylphenyl)-2-(2,4,6-trimethylp- henoxy)pyridine-3-carboxamide (Compound 1016), 6-(4-isobutoxyphenyl)-2-(4-methyl-1-piperidyl)-N-[(2-oxo-1H-pyridin-3-yl)- sulfonyl]pyridine-3-carboxamide (Compound 1017), 6-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-pyridyl]sulfonyl]-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 1018), N-(3-aminopyrazin-2-yl)sulfonyl-6-(4-ethoxyphenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 1019), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropoxyphenyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1020), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-isobutoxy-phenyl)-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1021), 6-(3-fluoro-4-propoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1022), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-ethyl-1-piperidyl)-6-(6-isopropoxy-3- -pyridyl]pyridine-3-carboxamide (Compound 1023), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclopentyl(methyl)aminol-6-(6-isoprop- oxy-3-pyridyl)pyridine-3-carboxamide (Compound 1025), N-[(6-amino-2-pyridyl)sulfonyl]-2-(benzylamino)-6-(6-isopropoxy-3-pyridyl- )pyridine-3-carboxamide (Compound 1026), N-[[6-(2-aminoethylamino)-2-pyridyl]sulfonyl]-6-phenyl-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1027), 6-(3-fluoro-5-isobutoxy-phenyl)-2-[3-(methoxymethyl)-1-piperidyl]-N-(1H-p- yrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1028), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(4-fluorophenyl)pyridine-3-carboxamide (Compound 1029), 2-(4-ethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-y- lsulfonyl)pyridine-3-carboxamide (Compound 1030), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2-isopropylphenoxy)pyridi- ne-3-carboxamide (Compound 1031), N-[[6-(methylamino)-2-pyridyl]sulfonyl]-6-phenyl-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 1032), 6-(4-methoxyphenyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trimethylphenoxy- )pyridine-3-carboxamide (Compound 1033), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-methoxy-2-pyridyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1034), N-[(6-amino-2-pyridyl)sulfonyl]-6-(p-tolyl)-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 1035), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(o-tolyl)pyridine-3-carboxamide (Compound 1036), N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-(4-methyl-1-piperidyl)pyridine-3- -carboxamide (Compound 1037), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[4-(1-hydroxy-1-methyl-eth- yl)-1-piperidyl]pyridine-3-carboxamide (Compound 1038), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2,2,5-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1040), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1041), 6-(3-fluoro-5-isopropoxy-phenyl)-2-(4-methyl-1-piperidyl)-N-(1H-pyrazol-3- -ylsulfonyl)pyridine-3-carboxamide (Compound 1042), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[4-(trifluor- omethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 1043), 6-(6-methoxy-5-methyl-3-pyridyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 1044), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(1-phenylpropoxy)pyridine-- 3-carboxamide (Compound 1045), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-phenoxy-pyridine-3-carboxa- mide (Compound 1046), N-(3-aminopyrazin-2-yl)sulfonyl-6-(p-tolyl)-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 1047), N-((6-aminopyridin-2-yl)sulfonyl)-6-(2,3-dihydrobenzofuran-5-yl)-2-(mesit- yloxy)-pyridine-3-carboxamide, N-((6-aminopyridin-2-yl)sulfonyl)-6-(5-fluoro-2-hydroxyphenyl)-2-(mesityl- oxy)-pyridine-3-carboxamide, N-[(6-amino-2-pyridyl)sulfonyl]-6-cyclopropyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 1050), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3R)-3- -methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1051), 6-(4-methylcyclohexen-1-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 1052), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3-flu- orooxetan-3-yl)methoxy]pyridine-3-carboxamide (Compound 1053), N-[[6-(2-aminoethylamino)-2-pyridyl]sulfonyl]-6-tert-butyl-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 1054), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-methylindol-6-yl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1056), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methylpyrazol-3-yl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 1057), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(isobutylamino)-2-pyridyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1059), 6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2R)-2-phenylpyrrolidin-1-yl]-N-(1H-py- razol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1060), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6-azaspiro[2.41heptan-6-yl)-6-(3-fluor- o-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1061), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-2-pyridyl]-2-(- 2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1062), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(2-pyridylsulfonyl)-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 1063), N-(4-aminophenyl)sulfonyl-2-(benzylamino)-6-tert-butyl-pyridine-3-carboxa- mide (Compound 1064), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2R)-2- ,3,3-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1065), N-(3-aminopyrazin-2-yl)sulfonyl-2-[(4-methyltetrahydropyran-4-yl)methylam- ino]-6-(p-tolyl)pyridine-3-carboxamide (Compound 1066), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-isopropylpyrazol-4-yl)-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1067), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(1-phen- ylpropoxy)pyridine-3-carboxamide (Compound 1068), 2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(2-pyridyl- sulfonyl)pyridine-3-carboxamide (Compound 1069), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butoxy-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 1070), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(1-methylindol-7-yl)oxy-py- ridine-3-carboxamide (Compound 1071), N-[(6-amino-2-pyridyl)sulfonyl]-2-isoindolin-2-yl-6-(6-isopropoxy-3-pyrid- yl)pyridine-3-carboxamide (Compound 1072), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethyl-4-oxo-pyrrolidin-1-yl)-6-- (3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1073) 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(6-isopropoxy-3-pyridyl)-N-(1H-- pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1074), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(1-ethylpropoxy)-3-pyridyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1076), N-[(6-amino-2-pyridyl)sulfonyl]-2-[[(1R,5S)-3-bicyclo[3.1.0]hexanyl]oxy]-- 6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1077), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(p-tolyl)pyridine-3-carboxamide (Compound 1078), 6-(4-isobutoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 1079), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(4-phenoxy-1- -piperidyl)pyridine-3-carboxamide (Compound 1080), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(3S)-3-meth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1081), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-methyl-1-piperidyl)-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 1083), N-(3-aminopyrazin-2-yl)sulfonyl-2-(4-methyl-1-piperidyl)-6-(p-tolyl)pyrid- ine-3-carboxamide (Compound 1084), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-ethylpyrrolidin-1-yl)-6-(6-isopropox- y-3-pyridyl)pyridine-3-carboxamide (Compound 1087), 2-[4-(cyclopropylmethoxy)-1-piperidyl]-6-(3-fluoro-5-isobutoxy-phenyl)-N-- (1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1088), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(4-cyano-2,6-dimethyl-phen- oxy)pyridine-3-carboxamide (Compound 1089), 2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-[(6-methox- y-2-pyridyl)sulfonyl]pyridine-3-carboxamide (Compound 1090), 6-(4,4-dimethylcyclohexyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 1091), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(3-phenoxypy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1092), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isobutoxyphenyl)-2-(4-methyl-1-piper- idyl)pyridine-3-carboxamide (Compound 1094), 6-(3-chlorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1095), 2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6-(3-ethoxy-5-fluoro-phenyl)-N-[(- 2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 1096), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S)-2-tert-butylpyrrolidin-1-yl]-6-(3- -fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1097), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-isop- ropyl-1-piperidyl)pyridine-3-carboxamide (Compound 1098), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-ethoxy-5-fluoro-phenyl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1099), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chlorophenyl)-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 1100), N-[(6-amino-2-pyridyl)sulfonyl]-4-methyl-6-phenyl-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 1102), N-(3-aminopyrazin-2-yl)sulfonyl-6-(1-isobutylpyrazol-4-yl)-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 1103), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(4-fluoro-2-methyl-phenoxy- )pyridine-3-carboxamide (Compound 1104), 6-[3-(cyclopropylmethoxy)phenyl]-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2- ,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1105), 2-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-N-[(6-amino-2-pyr- idyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1107), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- (2-methylcyclohexoxy)pyridine-3-carboxamide (Compound 1108), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-5-isobutoxy-phenyl)-2-(4-meth- yl-1-piperidyl)pyridine-3-carboxamide (Compound 1109), 2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazo- l-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1110), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-cyano-2-methoxy-phenyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 1111), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(3-phenylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 1112), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-benzyloxy-2-fluoro-phenyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 1113), N-(benzenesulfonyl)-6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1114), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-methoxy-3-pyridyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1115), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[3-(methoxym- ethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 1116), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclopropyl(methyl)aminol-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1117), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-ethylphenyl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 1118), 2-(2,6-dimethylmorpholin-4-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyra- zol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1119), N-[(6-amino-2-pyridyl)sulfonyl]-6-(o-tolyl)-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 1120), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,3-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1121), N-[[6-(2-dimethylaminoethylamino)-2-pyridyl]sulfonyl]-6-phenyl-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 1122), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-fluoro-5-isopropoxy-phenyl)pyridine-3-carboxamide (Compound 1123), 6-tert-butyl-N-(2-methoxyphenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamid- e (Compound 1124), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(cyclopropoxy)-3-pyridyl]-2-[(2S,5R)- -2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1125), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(cyclopropylamino)pyrimidin-5-yl]-2-- (2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1126), 2-(6-azaspiro[2.5]octan-6-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1127), N-[(6-amino-2-pyridyl)sulfonyl]-6-(ethylamino)-2-(2,4,6-trimethylphenoxy)- pyridine-3-carboxamide (Compound 1128), 2-(2,4-dimethylphenoxy)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-(p-tolyl)py- ridine-3-carboxamide (Compound 1129), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-ethoxypyrimidin-5-yl)-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 1130), N-[(6-amino-2-pyridyl)sulfonyl]-6-cyclohexyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 1131), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-cyclopropyl-1-piperidyl)-6-(6-isopro- poxy-3-pyridyl)pyridine-3-carboxamide (Compound 1132), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-ethoxy-2-pyridyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1133), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4,4-dimethyl-1-piperidyl)-6-(6-isoprop- oxy-3-pyridyl)pyridine-3-carboxamide (Compound 1134), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopentyloxy-2-pyridyl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1135), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(3S,5S)-3,5-dimethyl-1-piperidyl]-6-(6- -isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1136), N-[(6-amino-2-pyridyl)sulfonyl]-6-methyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 1137), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isopropoxy-phenyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 1138), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(dimethylamino)pyrimidin-5-yl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1139), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-4-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 1140), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-methoxy-2-pyridyl)pyridine-3-carboxamide (Compound 1141), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-methylpyrrolidin-1-yl)-N-(1H-pyrazol- -5-ylsulfonyl)pyridine-3-carboxamide (Compound 1142), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-(3-propoxyphenyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1143), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2S)-2- ,3,3-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1144), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(3R,5S)-3,5-dimethyl-1-piperidyl-6-(6-- isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1145), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,4-dimethoxyphenyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1146), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-- (2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1147), N-(2-aminothiazol-5-yl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 1148), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2R)-2- -(methoxymethyl)pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1149), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4-dimethylphenoxy)-6-(3-fluoro-5-iso- propoxy-phenyl)pyridine-3-carboxamide (Compound 1150), 6-(5-fluoro-2-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1151), 6-tert-butyl-N-[(2-methoxy-6-methyl-3-pyridyl)sulfonyl]-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1153), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(cyclobutoxy)pyridine-3-ca- rboxamide (Compound 1154), 2-(4-ethoxy-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 1155), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,3,3-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1156), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclopropylmethyl(isopropyl)aminol-6-(- 3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1157), N-[(2-amino-3-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1159), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-4-methyl-3-pyr- idyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1160), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- (4-methylene-1-piperidyl)pyridine-3-carboxamide (Compound 1162), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 1163), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(4-methoxy-1-piperidyl)pyr- idine-3-carboxamide (Compound 1164), N-[(6-amino-2-pyridyl)sulfonyl]-2-(1-cyclopropylethoxy)-6-(3-fluoro-5-iso- butoxy-phenyl)pyridine-3-carboxamide (Compound 1165), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(5R)-2- ,2,5-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1166), N-(4-aminothiazol-2-yl)sulfonyl-2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1168), 2-(2,3-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazo- l-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1169), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R)-2-tert-butylpyrrolidin-1-yl]-6-(3- -fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1170), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-methoxyphenyl)sulfonyl-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1171), N-[(6-amino-2-pyridyl)sulfonyl]-6-prop-1-ynyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 1172), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methoxyphenyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 1173), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-(3,3,4-trim- ethyl-1-piperidyl)pyridine-3-carboxamide (Compound 1174), 6-tert-butyl-N-(2-hydroxyphenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamid- e (Compound 1175), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-[(4R)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1176), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-isobutylpyrazol-4-yl)-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 1177), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-5-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 1178), 6-(4-ethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1179), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(1R,4S)-3-azabicyclo[2.2.1]heptan-3-yl- ]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1180), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-3-pyridyl]-2-(- 2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1181), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2-methyl-1-- piperidyl)pyridine-3-carboxamide (Compound 1182), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(hydroxymethyl)phenyl]-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 1183), N-(3-aminophenyl)sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1184), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-ethoxy-3-pyridyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1185), 6-(4-butoxy-3-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 1187), 6-(3-isopropoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 1188), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethyl-3-oxo-pyrrolidin-1-yl)-6-- (3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1189), N-(4-aminophenyl)sulfonyl-8,8-dimethyl-2-phenyl-6,7-dihydro-5H-quinoline-- 3-carboxamide (Compound 1190), N-(3-aminopyrazin-2-yl)sulfonyl-6-(6-methoxy-5-methyl-3-pyridyl)-2-(4-met- hyl-1-piperidyl)pyridine-3-carboxamide (Compound 1191), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isobutoxy-4-pyridyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1192), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3S)-3- -methyl-1-piperidyl]pyridine-3-carboxamide (Compound 1193), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-5-isobutoxy-phenyl)-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1194), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(4-methyltetrahydropyran-4-yl)methylam- ino]-6-(p-tolyl)pyridine-3-carboxamide (Compound 1196), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-isobutoxy-phenyl)-2-[(2S,5R- )-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1197), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1198), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(4-ethoxy-1-piperidyl)pyri- dine-3-carboxamide (Compound 1200), 6-(2-chloro-5-isobutoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1201), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-(4-propoxyphenyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1202), N-(3-aminopyrazin-2-yl)sulfonyl-6-(4-ethoxyphenyl)-2-[(4-methyltetrahydro- pyran-4-yl)methylamino]pyridine-3-carboxamide (Compound 1203), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-hydroxy-2-methyl-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 1204), N-[(6-amino-2-pyridyl)sulfonyl]-2-[1-(3-chlorophenyl)ethyl-methyl-aminol-- 6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1205), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-tert-butylpyrrolidin-1-yl)-6-(6-isop- ropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1206), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,3-benzodioxol-5-yl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 1207), N-(3-aminopyrazin-2-yl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 1208), (R)--N-((6-aminopyridin-2-yl)sulfonyl)-6'-isopropoxy-6-(3-phenylpiperidin- -1-yl)-[2,3'-bipyridine]-5-carboxamide, N-[(6-amino-2-pyridyl)sulfonyl]-2-[(3S,5S)-3,5-dimethyl-1-piperidyl]-6-(3- -fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1210), N-[(6-amino-2-pyridyl)sulfonyl]-6-isopropenyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 1211), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-methoxy-2-methyl-3-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 1212), 2-(2,4-dimethylphenoxy)-6-(3-fluoro-5-isopropoxy-phenyl)-N-(1H-pyrazol-3-- ylsulfonyl)pyridine-3-carboxamide (Compound 1213), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-ethoxy-1-piperidyl)-6-(6-isopropoxy-- 3-pyridyl)pyridine-3-carboxamide (Compound 1214), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(4-methoxyphenyl)pyridine-3-carboxamide (Compound 1215), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(1R,2R- ,4S)-norbornan-2-yl]oxy-pyridine-3-carboxamide (Compound 1216), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(3,4-difluorophenyl)pyridine-3-c- arboxamide (Compound 1217), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-ethylpyrrolidin-1-yl)-6-(3-fluoro-5-- isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1218), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-cyclopentyl-pyridine-3-car- boxamide (Compound 1219), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-methylpyrazol-1-yl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 1220) N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-chlorophenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 1221), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-ethyl-5-methyl-pyrrolidin-1-yl)-6-(3- -fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1222), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(5-isobutoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1224), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,5-dimethoxyphenyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1225), 6-(1-methylcyclopropyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 1226), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-norborn- an-2-yloxy-pyridine-3-carboxamide (Compound 1227), 6-[4-(aminomethyl)phenyl]-N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 1228), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cyclopropylmethoxy)-6-(3-fluoro-5-isob- utoxy-phenyl)pyridine-3-carboxamide (Compound 1229), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(2R)-2-(tri- fluoromethyl)pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1230), N-[(6-amino-2-pyridyl)sulfonyl]-6-isopropyl-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 1232), N-[(6-amino-2-pyridyl)sulfonyl]-5-benzyl-2-(2,4,6-trimethylphenoxy)pyridi- ne-3-carboxamide (Compound 1233), 6-(4-chloro-3-isobutoxy-phenyl)-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-N- -(1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1234), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(6-methoxy-2-pyridyl)-N-(1H-pyr- azol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1236), N-[(6-amino-2-pyridyl)sulfonyl]-2-(1-cyclobutylethoxy)-6-(3-fluoro-5-isob- utoxy-phenyl)pyridine-3-carboxamide (Compound 1238), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(4R)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1240), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(5S)-2- ,2,5-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1241), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isopropylpyrazol-3-yl)-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1242), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2,6-dimethylphenoxy)pyrid- ine-3-carboxamide (Compound 1243), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,3-difluorophenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1244), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-methoxy-1-piperidyl)-N-(1H-pyrazol-5- -ylsulfonyl)pyridine-3-carboxamide (Compound 1245), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1247), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(2S)-2-(tri- fluoromethyl)pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1248), N-(3-aminopyrazin-2-yl)sulfonyl-6-(6-methoxy-5-methyl-3-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 1249), N-[[6-(dimethylamino)-2-pyridyl]sulfonyl]-6-methyl-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 1250), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-hydroxy-4-methoxy-phenyl)-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 1251), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-ethoxypyrazin-2-yl)-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1252), N-[(6-amino-2-pyridyl)sulfonyl]-5-phenethyl-2-(2,4,6-trimethylphenoxy)pyr- idine-3-carboxamide (Compound 1253), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-fluoro-5-isobutoxy-phenyl)-4-methoxy-pyridine-3-carboxamide (Compound 1254), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-ethoxy-5-fluoro-phenyl)-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1255), 2-(2-benzylpyrrolidin-1-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol- -5-ylsulfonyl)pyridine-3-carboxamide (Compound 1257), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-isop- ropylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1258), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-methoxy-2,5-dimethyl-phenyl)-2-(2,2,- 4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1259) N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2S)-2- -phenylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1260), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[(3S)-3-phenyl-1-piperidyl- ]pyridine-3-carboxamide (Compound 1261), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isopropyl-4-pyridyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1262), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cycloheptoxy)-6-(3-fluoro-5-isobutoxy-- phenyl)pyridine-3-carboxamide (Compound 1263), N-[(6-amino-2-pyridyl)sulfonyl]-2-(8-azaspiro[3.51nonan-8-yl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1264), 6-tert-butyl-N-(3-hydroxyphenyl)sulfonyl-2-(p-tolyl)pyridine-3-carboxamid- e (Compound 1265), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-chloro-3-isobutoxy-phenyl)-2-(4-meth- yl-1-piperidyl)pyridine-3-carboxamide (Compound 1266), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,3-dimethylmorpholin-4-yl)-6-(3-fluor- o-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1267), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxy-3-methoxy-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 1268), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-5-methyl-- 2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1269), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-3-pyridyl]-2-[- (2S,5R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1270), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2-me- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1271), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-methyl-2-pyridyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1272), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[3-(trifluor- omethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 1274), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-pyrrolidin-1-ylpyrimidin-5-yl)-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1275), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-methylindazol-5-yl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 1276), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-fluoro-2-methoxy-4-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 1277), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-pyridyl)-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 1278), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1279), N-[(6-amino-2-pyridyl)sulfonyl]-6-cyclopentyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 1280), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-[[3-(triflu- oromethyl)cyclohexyl]amino]pyridine-3-carboxamide (Compound 1281), 2-(8-azaspiro[3.4]octan-8-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1282), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,3-dimethyl-1-piperidyl)-6-(6-isoprop- oxy-3-pyridyl]pyridine-3-carboxamide (Compound 1283), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-chloro-2-methoxy-4-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 1284), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(3-fluoro-5-isopropoxy-phenyl)-- N-(1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1285), 2-(3-cyclopropyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1286), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-methoxy-2-methyl-phenyl)-5-methyl-2-- (2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1287), N-(3-aminopyrazin-2-yl)sulfonyl-6-(1-isobutylpyrazol-4-yl)-2-(4-methyl-1-- piperidyl)pyridine-3-carboxamide (Compound 1288), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4R)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1289), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-methyl-2-pyridyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1290), 6-(4-chloro-3-propoxy-phenyl)-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-N-[- (2-oxo-1H-pyridin-3-yl)sulfonyl]pyridine-3-carboxamide (Compound 1293), N-(2-aminothiazol-4-yl)sulfonyl-6-tert-butyl-2-(2,4,6-trimethylphenoxy)py- ridine-3-carboxamide (Compound 1294), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-chlorophenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 1295), 6-(2,3-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trime- thylphenoxy)pyridine-3-carboxamide (Compound 1296), N-(4-aminophenyl)sulfonyl-6-(1-methylcyclopropyl)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 1297), N-(4-aminophenyl)sulfonyl-6-tert-butyl-2-(4-methoxy-1-piperidyl)pyridine-- 3-carboxamide (Compound 1298), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methylindazol-6-yl)-2-(2,4,6-trimeth- ylphenoxy)pyridine-3-carboxamide (Compound 1299), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-(p-tolyl)-2-(2,4,6-trimethylphenoxy- )pyridine-3-carboxamide (Compound 1300), 6-(5-ethoxy-2-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 1301), 2-(2,2-dimethylpyrrolidin-1-yl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-pyr- azol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1302), N-[(6-amino-2-pyridyl)sulfonyl]-2-(7-azaspiro[3.51nonan-7-yl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1303), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(2S)-2- -(trifluoromethyl)pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1304), N-[(6-amino-2-pyridyl)sulfonyl]-6-(dimethylamino)-2-(2,4,6-trimethylpheno- xy)pyridine-3-carboxamide (Compound 1306), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(6-oxo-1H-pyridin-2-yl)sulfonyl]-2-(2,- 2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1308), 2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-hydroxy- phenyl)sulfonyl-pyridine-3-carboxamide (Compound 1309), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-methylcyclopropyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1310), 6-tert-butyl-N-[(4-methyl-2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 1311), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-ethylpyrazol-4-yl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1312), 2-(2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyridin-1-yl)-N-[(6-amino-2-py- ridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1313), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(1-methyl-2-phenyl-ethoxy)- pyridine-3-carboxamide (Compound 1314), 6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-phenyl-1-piperidyl)-N-(1H-pyrazol-5-- ylsulfonyl)pyridine-3-carboxamide (Compound 1315), N-[(2-amino-3-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1316), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isopropylpyrazol-3-yl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 1317), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2-methylphenoxy)pyridine-- 3-carboxamide (Compound 1318), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-meth- yl-3-phenyl-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1319), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methoxy-5-methyl-phenyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 1320), N-(3-aminophenyl)sulfonyl-5-phenyl-2-(2,4,6-trimethylphenoxy)pyridine-3-c- arboxamide (Compound 1321), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(3R)-3-meth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1322), 2-(4,4-dimethyl-1-piperidyl)-6-(3-fluoro-5-isobutoxy-phenyl)-N-(1H-indol-- 4-ylsulfonyl)pyridine-3-carboxamide (Compound 1323), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-tetrahy- dropyran-4-yloxy-pyridine-3-carboxamide (Compound 1324), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,5-difluorophenyl)-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1325), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,6-dimethoxyphenyl)-2-(2,4,6-trimethy- lphenoxy)pyridine-3-carboxamide (Compound 1326), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-(2,3,3-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1327), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-2-pyridyl]-2-(- 2,2-dimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1328), 6-(4,4-difluorocyclohexyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 1329), N-[(6-amino-2-pyridyl)sulfonyl]-6-(cyclopenten-1-yl)-2-(2,4,6-trimethylph- enoxy)pyridine-3-carboxamide (Compound 1330), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2-fluoro-4-methyl-phenyl)pyridi- ne-3-carboxamide (Compound 1331), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-chloro-6-methoxy-3-pyridyl)-2-(2,4,6- -trimethylphenoxy)pyridine-3-carboxamide (Compound 1332), N-[(6-amino-2-pyridyl)sulfonyl]-2-(7-azaspiro[2.41heptan-7-yl)-6-(3-fluor- o-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1333), N-[(6-amino-2-pyridyl)sulfonyl]-6-phenyl-2-(2,2,4-trimethylpyrrolidin-1-y- l)pyridine-3-carboxamide (Compound 1334), 2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(4-isobutoxyphenyl)-N-(1H-pyraz- ol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1335), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-isopentylpyrazol-4-yl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 1336), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxyphenyl)-2-(2,4,6-trimethylphen- oxy)pyridine-3-carboxamide (Compound 1337), N-[(6-amino-2-pyridyl)sulfonyl]-2-[3-(3-chlorophenyl)-1-piperidyl]-6-(6-i- sopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1339), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[[6-(hydroxymethyl)-2-pyridyl]sulfonyl]- -2-(4-methyl-1-piperidyl)pyridine-3-carboxamide (Compound 1340), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-ethyl-3-methyl-1-piperidyl)-6-(6-iso- propoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1341), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(4-isopropylphenyl)pyridine-3-carboxamide (Compound 1343), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-hydroxyphenyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 1344), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(diethylamino)-2-pyridyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1345), 2-(2,5-dimethyl-3-phenyl-pyrrolidin-1-yl)-6-(3-fluoro-5-isobutoxy-phenyl)- -N-(1H-pyrazol-5-ylsulfonyl)pyridine-3-carboxamide (Compound 1348), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-norbornan-2-yloxy-pyridine- -3-carboxamide (Compound 1349), N-(3-aminophenyl)sulfonyl-6-tert-butyl-2-(2-fluoro-5-methyl-phenyl)pyridi- ne-3-carboxamide (Compound 1350), N-(3-aminopyrazin-2-yl)sulfonyl-6-(3-fluoro-5-isopropoxy-phenyl)-2-(p-tol- yl)pyridine-3-carboxamide (Compound 1351), 6-(6-isopropoxy-3-pyridyl)-N-(1H-pyrazol-5-ylsulfonyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1352), N-(1H-pyrazol-3-ylsulfonyl)-6-(2-pyridyl)-2-(2,4,6-trimethylphenoxy)pyrid- ine-3-carboxamide (Compound 1353), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(2R)-2-meth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1354), 6-tert-butyl-N-[(5-methyl-2-pyridyl)sulfonyl]-2-(p-tolyl)pyridine-3-carbo- xamide (Compound 1355), N-(benzenesulfonyl)-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide, 6-cyclohexyl-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,4,6-trimethylphenox- y)pyridine-3-carboxamide (Compound 1357), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(2-methoxy-3-pyridyl)sulfamoyl]-2-[(4S- )-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1359), N-[(3R)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1360), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- (1-methyl-2-tetrahydropyran-4-yl-ethoxy)pyridine-3-carboxamide (Compound 1361), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- [(2R,4S)-4-fluoro-2-methyl-pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1362), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-ethoxy-5-methyl-2-pyridyl)-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1363), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-phenyl-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 1364), N-[(6-amino-2-pyridyl)sulfonyl]-2-(1,1-dimethyl-2-phenyl-ethoxy)-6-(3-flu- oro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1365), isopropyl 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-(2,4,6-trimethylphenoxy)-2-- pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (Compound 1366), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,6,- 6-tetramethyl-3H-pyran-4-yl)pyridine-3-carboxamide (Compound 1368), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6,6-dimethyl-2,3-dihydropyran-4-yl)-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1369), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethylcyclohexen-1-yl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1370), tert-butyl 5-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (Compound 1371), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]-5-vinyl-pyridine-3-carboxamide (Compound 1373), N-[(6-amino-2-pyridyl)sulfonyl]-2-(1-cyclopentylethoxy)-6-(3-fluoro-5-iso- butoxy-phenyl)pyridine-3-carboxamide (Compound 1374), N-[(6-amino-5-hydroxy-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolid- in-1-yl]-6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1375), N-[(6-amino-2-pyridyl)sulfonyl]-6-cycloheptyl-2-(2,4,6-trimethylphenoxy)p- yridine-3-carboxamide (Compound 1376), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-hex-1-enyl-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1377), N-[(6-amino-2-pyridyl)sulfonyl]-6-norbornan-2-yl-2-[(4S)-2,2,4-trimethylp- yrrolidin-1-yl]pyridine-3-carboxamide (Compound 1378), N-[(6-amino-2-pyridyl)sulfonyl]-6-[(E)-2-cyclopropylvinyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1379), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[4-(trifluoromethyl)cycloh- exen-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1380), 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-2-tert-butyl-6-(2,2,4-trimeth- ylpyrrolidin-1-yl)-3-pyridyl]cyclohex-3-ene-1-carboxylic acid (Compound 1381), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(1-methyl-3,6-dihyd- ro-2H-pyridin-4-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxami- de (Compound 1382), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(diethylamino)-3-methyl-2-pyridyl]-2- -(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1383), N-[(6-amino-2-pyridyl)sulfonyl]-5-phenyl-2-(2,2,4-trimethylpyrrolidin-1-y- l)pyridine-3-carboxamide (Compound 1384), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-fluoro-5-isobutoxy-phenyl)-6-[(4R)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1385), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,5-diisopropylpyrazol-1-yl)-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1387), tert-butyl 3-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-2-tert-butyl-6-(2,2,4-trimeth- ylpyrrolidin-1-yl)-3-pyridyl]-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate (Compound 1388), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-benzyl-3,6-dihydro-2H-pyridin-4-yl)-- 2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1389), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,2-dimethylprop-1-enyl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 1390), N-(3-acetamidopyrrolidin-1-yl)sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2-- (2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1391), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cyclohexylmethoxy)-6-(3-fluoro-5-isobu- toxy-phenyl)pyridine-3-carboxamide (Compound 1395), N-(benzenesulfonyl)-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4R)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1396), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -[6-(1-ethylpropylamino)-3-pyridyl]pyridine-3-carboxamide (Compound 1397), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -[6-(isobutylamino)-3-pyridyl]pyridine-3-carboxamide (Compound 1398), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[[(1S)-1,2-dimethylpropyl]amino]-3-p- yridyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1399), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(3S)-2,2-dideuterio-3,5,5-trimethyl-py- rrolidin-1-yl]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1400), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-azabicyclo[3.1.11heptan-3-yl)-6-tert- -butyl-pyridine-3-carboxamide (Compound 1401), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)cyclohexen-1-yl]-2-- (2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1402), benzyl 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-2-tert-butyl-6-(2,2,4-trimeth- ylpyrrolidin-1-yl)-3-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (Compound 1404), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(5,5-dimethyl-3-oxo-cycloh- exen-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1405), N-((6-aminopyridin-2-yl)sulfonyl)-6-(3-fluoro-5-isobutoxyphenyl)-2-(2-met- hylcyclobutoxy)nicotinamide, N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutoxy-5-methyl-pyrazol-1-yl)-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1407), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-fluoro-5-isobutoxy-phenyl)-6-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1409), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4,7,7-trimethyl-3-bicyclo[2.2.1- ]hept-2-enyl)-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1410), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutylpyrazol-1-yl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1411), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,3-dihydrofuran-4-yl)-2-(2,4,6-trimet- hylphenoxy)pyridine-3-carboxamide (Compound 1412), N-[[3-(dimethylamino)-1-piperidyl]sulfonyl]-6-(3-fluoro-5-isobutoxy-pheny- l)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1414), N-[(6-amino-2-pyridyl)sulfonyl]-6-[isobutyl(methyl)aminol-5-methyl- -2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1416), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(isobutylamino)-3-methyl-2-pyridyl]-- 2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1417), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-cyclobutylethoxy)-6-(3-fluoro-5-isob- utoxy-phenyl)pyridine-3-carboxamide (Compound 1418), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-cyano-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1419), N-[(6-amino-2-pyridyl)sulfonyl]-6-methyl-2-[(4S)-2,2,4-trimethylpyrrolidi- n-1-yl]pyridine-3-carboxamide (Compound 1420), N-[(6-amino-2-pyridyl)sulfonyl]-6-isopropenyl-2-[(4S)-2,2,4-trimethylpyrr- olidin-1-yl]pyridine-3-carboxamide (Compound 1423), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-fluoro-5-(2-hydroxy-2-methyl-propoxy- )phenyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1424), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-pheneth- yloxy-pyridine-3-carboxamide (Compound 1426), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5,5-dimethyl-2-oxo-cyclohexyl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1427), N-[(6-amino-5-benzyloxy-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-pheny- l)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1429), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-- 1-yl]-6-(3-fluoro-5-isobutoxy-phenyl)-4-hydroxy-pyridine-3-carboxamide (Compound 1430), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-isobutylpyrazol-1-yl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1431), ethyl 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-(2,4,6-trimethylphenoxy)-2-- pyridyl]cyclohex-3-ene-1-carboxylate (Compound 1432), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[1-(3-p- yridyl)ethoxy]pyridine-3-carboxamide (Compound 1434), N-[[(3S)-3-amino-1-piperidyl]sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1435), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6-isopropoxy-3-pyridyl)-6-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1436) N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,4-dioxaspiro[4.51dec-8-en-9-yl)-2-(2- ,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1437), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,4-dihydro-2H-pyran-6-yl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1438), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-hydroxy-5,5-dimethyl-cyclohexyl)-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1439), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-cyclopentylethoxy)-6-(3-fluor- o-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1440), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(1-methylpyrazol-4-yl)-2-(- 2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1441) N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-f[(1R)-1,2-dimethylpropyl]amino]-3-p- yridyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1442), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isobutoxypyrazol-1-yl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1443), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4R)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1444), N-[(3-amino-3-methyl-1-piperidyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl- )-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1445), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cyclopropoxy)-6-(3-fluoro-5-iso- butoxy-phenyl)pyridine-3-carboxamide (Compound 1446), N-[(3-amino-1-piperidyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,- 4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1447), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-pyridylsulfamoyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1448), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cyclopentylmethoxy)-6-(3-fluoro-5-isob- utoxy-phenyl)pyridine-3-carboxamide (Compound 1450), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cyclopentoxy)-6-(3-fluoro-5-isobutoxy-- phenyl)pyridine-3-carboxamide (Compound 1451), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-methoxyphenyl)sulfonyl-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1452), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,3-dihydrofuran-4-yl)-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1455), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-fluoro-5-isobutoxy-phenyl)-3-(2,4,6-- trimethylphenoxy)pyridine-2-carboxamide (Compound 1456), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,3-difluorocyclobutoxy)-6-(3-fluoro-5- -isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1458), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(1,4-dioxaspiro[4.51dec-8-- en-8-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1459), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6,6-dimethyl-2,3-dihydropyran-4-yl)-2-- (2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1460), 5-(4-acetylcyclohexen-1-yl)-N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-- 2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1461), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,3-dimethyl-6-oxo-cyclohexen-1-yl)-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1462), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-f[(1S)-1,3-dimethylbutyl]amin- o]-3-pyridyl-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1463), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3S)-t- etrahydrofuran-3-yl]oxy-pyridine-3-carboxamide (Compound 1464), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-cyclohexylethoxy)-6-(3-fluoro-5-isob- utoxy-phenyl)pyridine-3-carboxamide (Compound 1465), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,2-dimethyltetrahydropyran-4-yl)-2-(2- ,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1466), N-(3-aminopyrrolidin-1-yl)sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2- ,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1467), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(1,4-dioxaspiro[4.51dec-8-- en-9-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1469), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,5-dimethoxyphenyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1471), N-[(6-amino-4-methyl-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1472), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-ethoxy-5-methyl-pyrazol-1-yl)- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1473), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethylcyclohexyl)-2-(2,4,6-tri- methylphenoxy)pyridine-3-carboxamide (Compound 1475), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cyclohexoxy)-6-(3-fluoro-5-isobutoxy-p- henyl)pyridine-3-carboxamide (Compound 1477), N-[(6-amino-2-pyridyl)sulfonyl]-2-(1-benzylcyclobutoxy)-6-(3-fluoro-5-iso- butoxy-phenyl)pyridine-3-carboxamide (Compound 1479), N--[(R)-amino(6-aminopyridin-2-yl)oxo-.lamda..sup.6-sulfanylidene]-6-tert- -butyl-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1481), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(6-methoxy-4-methyl-2-pyridyl)sulfonyl- ]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1482), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(6-methoxy-2-pyridyl)sulfonyl]-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1483), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-2-cyclohexylvi- nyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1484), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(3,4-dihydro-2H-pyran-6-yl- )-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1485), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,2-dimethylpropyl)-2-(2,4,6-tr- imethylphenoxy)pyridine-3-carboxamide (Compound 1486), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(3,4-dihydro-2H-pyran-5-yl- )-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1487), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-ethoxy-5-methyl-phenyl)-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1488), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,2-dimethylpropyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1489), Ethyl (E)-3-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-2-tert-butyl-6-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]-3-pyridyl]prop-2-enoate (Compound 1490), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6-isopropoxy-3-pyridyl)-6-[(4R)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1491), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,3-dimethyl-5-oxo-cyclohexyl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1492), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4,4-dimethylcyclohexen-1-yl)-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1493), N-[(6-amino-2-pyridyl)sulfonyl]-6-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-2- -(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1494), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(3,6-dihydro-2H-pyran-4-yl- )-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1495), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- (tetrahydrofuran-3-ylmethoxy)pyridine-3-carboxamide (Compound 1499), N-[(6-amino-2-pyridyl)sulfonyl]-6-tetrahydropyran-2-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1500), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3,3,5,- 5-tetramethylcyclopenten-1-yl)pyridine-3-carboxamide (Compound 1502), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-tetrahydropvran-2-yl-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1503), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-3-pyridyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1504), N-[(6-amino-2-pyridyl)sulfonyl]-6-isopropyl-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1505), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -[6-[isobutyl(methyl)aminol-3-pyridyl]pyridine-3-carboxamide (Compound 1506), N-[(6-amino-2-pyridyl)sulfonyl]-6-ethyl-2-[(4S)-2,2,4-trimethylpyr- rolidin-1-yl]pyridine-3-carboxamide (Compound 1507), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[[3-(methylamino)-1-piperidyl]sulfonyl]- -2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1508), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,2-dimethylprop-1-enyl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1510), N-((6-aminopyridin-2-yl)sulfonyl)-6-(tert-butyl)-2-(2,2,4-trimethylpyrrol- idin-1-yl)nicotinamide, N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-ethoxy-4-methyl-2-pyridyl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1512), N-[(6-amino-2-pyridyl)sulfonyl]-6-(cyclohepten-1-yl)-2-(2,4,6-trimethylph- enoxy)pyridine-3-carboxamide (Compound 1513), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-4-methyl-3-pyridyl)pyridine-3-carboxamide (Compound 1514), N-(benzenesulfonyl)-6-[3-fluoro-5-(3-hydroxy-2-methyl-propoxy)phenyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1515), N-[(6-amino-2-pyridyl)sulfonyl]-5-methyl-6-(2-methylpyrrolidin-1-y- l)-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1516), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,6-dihydro-2H-thiopyran-4-yl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1517), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-bicyclo[2.2.1]hept-2-enyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 1518), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)cyclohexyl]-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1519), tert-butyl N-[1-[[6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4-trimethylpyrrolidin-1-yl)- pyridine-3-carbonyl]sulfamoyl]-3-methyl-3-piperidyl]carbamate (Compound 1520), N-[(5-amino-3-azabicyclo[3.1.0]hexan-3-yl)sulfonyl]-6-(3-fluoro-5-- isobutoxy-phenyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carbox- amide (Compound 1521), tert-butyl 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-2-tert-butyl-6-(2,2,4-trimeth- ylpyrrolidin-1-yl)-3-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (Compound 1522), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxypyrazin-2-yl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1523), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,4-dihydro-2H-pyran-5-yl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1524), N-cyclopropylsulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1525), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[[(1R)-1,3-dimethylbutyl]amino]-3-py- ridyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1527), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5,5-dimethyl-3-oxo-cyclohexen-1-yl)-2-- (2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1528), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-azabicyclo[3.1.11heptan-3-yl)-6-(3-f- luoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1529), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-cyclopropylcyclobutoxy)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1530), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,5,- 5-tetramethyl-3-furyl)pyridine-3-carboxamide (Compound 1531), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutoxy-4-methyl-pyrazol-1-yl)-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1532), N-[3-[acetyl(methyl)amino]pyrrolidin-1-yl]sulfonyl-6-(3-fluoro-5-i- sobutoxy-phenyl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1533), N-[(6-amino-2-pyridyl)sulfonyl]-6-tetrahydrofuran-3-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1534), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-2-(4-methoxyphenyl)vi- nyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1535), N-[(6-amino-2-pyridyl)sulfonyl]-6-methoxy-2-[(4S)-2,2,4-trimethylpyrrolid- in-1-yl]pyridine-3-carboxamide (Compound 1536), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isobutoxy-2-methyl-3-pyridyl)pyridine-3-carboxamide (Compound 1537), N-(benzenesulfonyl)-6-(3-fluoro-5-hydroxy-phenyl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1538), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-(2-methylpropanoyl)-3,6-dihydro-2H-p- yridin-4-yl]-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1540), N-[(2-amino-3-pyridyl)sulfonyl]-2-[(4S)-3,3-dideuterio-2,2-dimethy- l-4-(trideuteriomethyl)pyrrolidin-1-yl]-6-(6-isopropoxy-3-pyridyl)pyridine- -3-carboxamide (Compound 1543), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4,7,7-trimethyl-3-bicyclo[2.2.1]hept-2- -enyl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1544), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(3-methoxy-1-piperidyl)sulfonyl- ]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1545), (E)-3-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-2-tert-butyl-6-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]-3-pyridyl]prop-2-enoic acid (Compound 1547), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- (2,5,5-trimethylmorpholin-4-yl)pyridine-3-carboxamide (Compound 1548), N-[(6-amino-2-pyridyl)sulfonyl]-5-(trifluoromethyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1550), N-((6-aminopyridin-2-yl)sulfonyl)-6-(3-fluoro-5-isobutoxyphenyl)-2-(2,2,4- ,4-tetramethylcyclopentyl)nicotinamide, N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methylpyrrolidin-1-yl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 1553), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[3-(methylamino)pyrrolidin-1-yl]sulfony- l-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1554), N-[(6-amino-2-pyridyl)sulfonyl]-6-(trifluoromethyl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1556), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1557), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,4-dioxaspiro[4.51dec-8-en-8-y- l)-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1558), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-benzyloxycyclobutoxy)-6-(3-fluoro-5-- isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1559), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-methylsulfonylpyrrolidin-1-yl)sulfon- yl-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1560), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(2-methylprop-1-eny- l)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1561), N-[(6-amino-5-hydroxy-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-- phenyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1563), N-[(6-amino-2-pyridyl)sulfonyl]-6-cyano-2-[(4S)-2,2,4-trimethylpyrrolidin- -1-yl]pyridine-3-carboxamide (Compound 1564), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-2-[4-(trifluoromethyl- )phenyl]vinyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxami- de (Compound 1566), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-fluoro-5-(3-hydroxy-2-methyl-propoxy- )phenyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1567), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-ethoxy-5-(trifluoromethyl)phenyl]-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1569), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- (tetrahydropyran-2-ylmethoxy)pyridine-3-carboxamide (Compound 1570), N-[(6-amino-2-pyridyl)sulfonyl]-5-[(E)-2-cyclopropylvinyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1571), N-[(6-amino-2-pyridyl)sulfonyl]-2-(5,7-dimethylindolin-1-yl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1572), N-[(6-amino-2-pyridyl)sulfonyl]-6-isopropoxy-2-[(4S)-2,2,4-trimethylpyrro- lidin-1-yl]pyridine-3-carboxamide (Compound 1573), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2,4-dimethyl-3-pyridyl)oxyl-6-(3-fluo- ro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1574), N-[(6-amino-2-pyridyl)sulfonyl]-6-[(1S,2S)-2-(methoxymethyl)cyclopropyl]-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1575), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-bicyclo[2.2.1]hept-2-enyl)-6-- tert-butyl-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1577), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(4,7,7-trimethyl-3-bicyclo- [2.2.1]hept-2-enyl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxami- de (Compound 1578), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-tetr- ahydropyran-4-ylethoxy)pyridine-3-carboxamide (Compound 1579), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cyclobutoxy)-6-(3-fluoro-5-isobutoxy-p- henyl)pyridine-3-carboxamide (Compound 1580), N-(benzenesulfonyl)-6-[3-fluoro-5-(2-hydroxy-2-methyl-propoxy)phenyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1581), N-[(3-acetamido-1-piperidyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phen- yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1586), N-[(6-amino-5-benzyloxy-2-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethy- lpyrrolidin-1-yl]-6-(6-isopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 1588), N-[(6-amino-2-pyridyl)sulfonyl]-6-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-5- -methyl-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1589), N-[(6-amino-2-pyridyl)sulfonyl]-5-(1,2-dimethylprop-1-enyl)-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1590), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(3R)-t- etrahydrofuran-3-yl]oxy-pyridine-3-carboxamide (Compound 1592), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1593), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,6-dihydro-2H-pyran-4-yl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1594), N-[(6-amino-2-pyridyl)sulfonyl]-6-tetrahydropyran-4-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1595), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,3-dimethyl-6-oxo-cyclohexen-1-yl)-2-- (2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1598), N-[(6-amino-2-pyridyl)sulfonyl]-6-isobutyl-2-[(4S)-2,2,4-trimethylpyrroli- din-1-yl]pyridine-3-carboxamide (Compound 1599), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[[3-(methanesulfonamido)-1-piperidyl]su- lfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1600), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(cyclohexen-1-yl)-2- -(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1601), N--[(S)-amino(6-aminopyridin-2-yl)oxo-.lamda..sup.6-sulfanylidene]-6-tert- -butyl-2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1602), N-[(6-amino-2-pyridyl)sulfonyl]-5-chloro-2-[(4S)-2,2,4-trimethylpyrrolidi- n-1-yl]pyridine-3-carboxamide (Compound 1603), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-tetr- ahydrofuran-2-ylethoxy)pyridine-3-carboxamide (Compound 1604), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[2-(4-p- yridyl)ethoxy]pyridine-3-carboxamide (Compound 1605), N-[(6-amino-2-pyridyl)sulfonyl]-5-fluoro-2-[(4S)-2,2,4-trimethylpyrrolidi- n-1-yl]pyridine-3-carboxamide (Compound 1607), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(3-hydroxy-1-piperidyl)sulfonyl]-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1608), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,2,5,5-tetramethyl-3-furyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 1609), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-5-methyl-2-pyr- idyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1610), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(4R)-4-ethyl-2,2-dimethyl-pyrro- lidin-1-yl]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1611), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(4S)-4-ethyl-2,2-dimethyl-pyrrolidin-1- -yl]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1612), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-3,3-dimethylbu- t-1-enyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1613), N-[[(3R)-3-amino-1-piperidyl]sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1614), 6-(4-acetylcyclohexen-1-yl)-N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4- ,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1615), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-pent-1-enyl-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1617), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isobutoxy-4-pyridyl)-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1618), 6-(3-fluoro-5-isobutoxy-phenyl)-N-pyrrolidin-1-ylsulfonyl-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1619), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutoxypyrazol-1-yl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1620), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-meth- oxycyclohexoxy)pyridine-3-carboxamide (Compound 1622), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -(6-isopropoxy-2-methyl-3-pyridyl)pyridine-3-carboxamide (Compound 1623), tert-butyl 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (Compound 1624), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- [2-(2-pyridyl)ethoxy]pyridine-3-carboxamide (Compound 1625), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-2-ethoxyvinyl]-2-[(4S- )-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1626), N-[(6-amino-2-pyridyl)sulfonyl]-6-cyclopropyl-2-[(4S)-2,2,4-trimethylpyrr- olidin-1-yl]pyridine-3-carboxamide (Compound 1627), N-[(6-amino-2-pyridyl)sulfonyl]-5-bromo-6-tert-butyl-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1628), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethylcyclopentoxy)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1629), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropylcyclohexen-1-yl)-2-(2,4,6-t- rimethylphenoxy)pyridine-3-carboxamide (Compound 1630), 6-(4-acetylcyclohexyl)-N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,4,6-trimethyl- phenoxy)pyridine-3-carboxamide (Compound 1631), N-[(6-amino-2-pyridyl)sulfonyl]-6-tetrahydropyran-3-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1632), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-2-cyclopentylvinyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1633), 6-(1-acetyl-4-piperidyl)-N-[(6-amino-2-pyridyl)sulfonyl]-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1634), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2,4,4-tetramethylpyrrolidin-1-yl)-6-- (trifluoromethyl)pyridine-3-carboxamide (Compound 1635), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-hydroxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1636), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-4-methyl-2-pyridyl)-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1637), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2,4,4-tetramethylpyrrolidin-1-yl)-5-- (trifluoromethyl)pyridine-3-carboxamide (Compound 1638), N-[(6-amino-2-pyridyl)sulfonyl]-2-[1-(2,2-dimethylcyclopropyl)propoxyl-6-- (3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1639), 6-(3-fluoro-5-isobutoxy-phenyl)-N-tetrahydrofuran-3-ylsulfonyl-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1640), N-[(6-amino-2-pyridyl)sulfonyl]-5-chloro-6-(3-fluoro-5-isobutoxy-phenyl)-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1641), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,2,3,6-tetrahydropyridin-4-v)-- 2-(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1643), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(1-meth- ylcyclobutoxy)pyridine-3-carboxamide (Compound 1644), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-3-methyl-2-pyr- idyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1645), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutoxy-5-methyl-phenyl)-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1646), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(2,2,6,6-tetramethy- l-3H-pyran-4-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1647), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-hydroxypyrrolidin-1-yl)sulfonyl-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1648), 6-(1-acetyl-3,6-dihydro-2H-pyridin-4-yl)-N-[(6-amino-2-pyridyl)sulfonyl-2- -(2,4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1649), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,7,7-trimethylnorbornan-2-yl)-2-(2,4,- 6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1650), N-[(6-acetamido-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1652), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[2-(3-p- yridyl)ethoxy]pyridine-3-carboxamide (Compound 1654), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxy-4-methyl-2-pyridyl)-2-[(4S- )-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1656), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-azabicyclo[2.2.2]octan-3-yl)-6-(3-fl- uoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1657), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2,4,4-tetramethylpyrrolidin-1-yl)-4-- (trifluoromethyl)pyridine-3-carboxamide (Compound 1658), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxy-3-methyl-2-pyridyl)-2-(2,2- ,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1659), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(tetrah- ydrofuran-2-ylmethoxy)pyridine-3-carboxamide (Compound 1661), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropoxy)-2-pyridyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1663), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)cyclohexen-1- -yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1664), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-2-cyclopropylvinyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1665), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- [4-(trifluoromethyl)cyclohexen-1-yl]pyridine-3-carboxamide (Compound 1667), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- [(1-methylcyclopropyl)methoxy]pyridine-3-carboxamide (Compound 1668), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isopropoxy-5-methyl-phenyl)-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1671), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)cyclohexyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1672), N-[(6-amino-2-pyridyl)sulfonyl]-5-fluoro-2,6-bis[(4S)-2,2,4-trimethylpyrr- olidin-1-yl]pyridine-3-carboxamide (Compound 1673), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-isopropoxy-5-(trifluoromethyl)phenyl- ]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1674), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-- (2,2,5,5-tetramethylmorpholin-4-yl)pyridine-3-carboxamide (Compound 1675), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-cyclopropylethyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1677), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(difluoromethoxy)-3-pyridyl]-2-[(2S,- 5R)-2,5-dimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1679), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-tetr- ahydropyran-2-ylethoxy)pyridine-3-carboxamide (Compound 1680), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[(E)-5-methylhex-1-enyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1682), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methylprop-1-enyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1683), tert-butyl 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]-2-pyridyl]-2,3-dihydropyrrole-1-carboxylate (Compound 1684), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-cyclopropylethoxy)-6-(3-fluoro-5-iso- butoxy-phenyl)pyridine-3-carboxamide (Compound 1685), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-phen- ylbutoxy)pyridine-3-carboxamide (Compound 1686), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[4-(4-p- yridyl)butoxy]pyridine-3-carboxamide (Compound 1687), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[4-(2-p- yridyl)butoxy]pyridine-3-carboxamide (Compound 1688), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-phen- ylbutoxy)pyridine-3-carboxamide (Compound 1689), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[4-(3-p- yridyl)butoxy]pyridine-3-carboxamide (Compound 1690), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[3-(3-p- yridyl)propoxy]pyridine-3-carboxamide (Compound 1691), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-pyra- zol-1-ylpropoxy)pyridine-3-carboxamide (Compound 1692), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[3-(2-p- yridyl)propoxy]pyridine-3-carboxamide (Compound 1693), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-phen- ylpropoxy)pyridine-3-carboxamide (Compound 1694), N-[(2-amino-3-pyridyl)sulfonyl]-6-[6-(2-isopropoxyethoxy)-5-methyl-3-pyri- dyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1695), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[2-(2-ethoxyethoxy)ethoxyl-4-methyl-- 2-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1696), N-[(6-aminopyridin-2-yl)sulfonyl]-6-tetrahydropyran-2-yl-2-[(4S)-2,2,4-tr- imethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1697), N-[(6-aminopyridin-2-yl)sulfonyl]-6-tetrahydropyran-2-yl-2-[(4S)-2,2,4-tr- imethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,4-dihydro-2H-pyran-6-yl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1699) N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2-ethoxyethoxy)-4-methyl-2-pyridyl]- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1700), N-[(6-amino-2-pyridyl)sulfonyl]-5-(o-tolyl)-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 1701), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-isopropoxy-5-methyl-3-pyridyl)-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1702), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2-isopropoxyethoxy)-4-methyl-2-pyri- dyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1703), N-[[6-[2-(4-fluorophenyl)ethoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1704), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,4-dimethoxyphenyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1705), N-[(2-amino-3-pyridyl)sulfonyl]-6-[2-(hydroxymethyl)phenyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1706), N-[(2-amino-3-pyridyl)sulfonyl]-6-[2-(hydroxymethyl)-4-methoxy-phenyl]-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1707), N-[[6-(3-phenylpyrrolidin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1708), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isopropoxypyrazol-1-yl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1709), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-[4-(trifluoromethyl)cyclohexyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1710), N-[[6-[methyl(propyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1711), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-hydroxyphenyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1712), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,3-dimethylphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1713), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1714), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[2-(2-ethoxyethoxy)ethoxyl-5-methyl-- 3-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1715), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3,5-difluorophenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1716), N-[[6-[(4-methoxyphenyl)methyl-methyl-aminol-2-pyridyl]sulfonyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1717), N-[(6-tert-butoxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)p- yridine-3-carboxamide (Compound 1718), N-[[6-(3-methoxy-5-methyl-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1719), N-[[6-(2-cyanophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 1720), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3,5-dichlorophenyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1721), N-[[6-(4-isopropylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 1722), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[[1-(2-- hydroxy-2-methyl-propyl)cyclopropyl]methylamino]pyridine-3-carboxamide (Compound 1723), N-((6-aminopyridin-2-yl)sulfonyl)-5-(3,5-dichlorophenyl)-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)nicotinamide, N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-phenyl-2-[(4S)-2,2,4-trimethylp- yrrolidin-1-yl]pyridine-3-carboxamide (Compound 1725), N-[(6-amino-2-pyridyl)sulfonyl]-5-[(E)-2-(4-methoxyphenyl)vinyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1726), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-ethoxy-5-methyl-3-pyridyl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1727), N-[(6-amino-2-pyridyl)sulfonyl]-6-[5-methyl-6-[(1S)-1-methylpropoxy]-3-py- ridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1728), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-ethyl-2,4-dimethyl-pyrrolidin-1-yl)-- 6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1729) (Isomer 4, SR), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-cyclohexylethoxy)-5-fluoro-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1730), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-hydroxy-4-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1731), N-[(2-amino-3-pyridyl)sulfonyl]-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6- -(3-isobutoxypyrazol-1-yl)pyridine-3-carboxamide (Compound 1732), N-[[6-(4-cyclopentylpiperazin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1733), N-[[6-(pyrrolidin-3-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 1734), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-methoxyphenyl)-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 1735), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2,5-dimethylphenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1736), N-((6-aminopyridin-2-yl)sulfonyl)-6-(3-fluoro-5-isobutoxyphenyl)-2-(7-met- hyl-5-azaspiro[3.4]octan-5-yl)nicotinamide, N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(hydroxymethyl)phenyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1738), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(diethylamino)-6-methyl-4-pyridyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1739), N-[(2-amino-3-pyridyl)sulfonyl]-6-[1-methyl-3-(trifluoromethyl)pyr- azol-4-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1740), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isobutoxy-5-methyl-3-pyridyl)-2-[(4S- )-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1741), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(2-ethoxyethoxy)pyrazol-1-yl]-2-[(4S- )-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1742), 6-(3-isobutoxy-4-methyl-pyrazol-1-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1743), N-[[6-(4-acetyl-2-methoxy-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1744), 6-(6-ethoxy-4-methyl-2-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1745), N-[(6-amino-2-pyridyl)sulfonyl]-2-(5,5-dimethyl-6-azaspiro[2.41heptan-6-y- l)-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1746), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-methoxy-3-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1747), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-methoxy-6-methyl-4-pyridyl)-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1748), N-[[6-(3,5-dimethyl-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1749), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(4-hydroxyphenyl)sulfonyl-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1750), N-[[6-(1-naphthyloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 1751), 6-(2,5-dimethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1752), N-[(6-prop-2-ynoxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)- pyridine-3-carboxamide (Compound 1753), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(5-meth- yl-7-azaspiro[2.41heptan-7-yl)pyridine-3-carboxamide (Compound 1754), N-[[6-(3-phenyl-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 1755), N-[[6-(4-tert-butylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 1756), N-[[6-[4-(dimethylamino)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1757), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isobutoxy-4-methyl-pyrazol-1-yl)-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1758), N-[(6-amino-2-pyridyl)sulfonyl]-5-(1,1,4,4,7-pentamethyltetralin-6- -yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1759), 6-(4-isobutoxypyrazol-1-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1760), N-[[6-(3,4-dimethoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1761), N-[(6-amino-5-benzyloxy-2-pyridyl)sulfonyl]-2-(2,6-dimethylphenoxy)-6-(3-- fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1762), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-[4-(trifluoromethoxy)phenyl]-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1763), N-[[6-(tetrahydrofuran-2-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1764), 6-tert-butyl-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trimethylp- yrrolidin-1-yl]pyridine-3-carboxamide (Compound 1765), N-[(2-amino-3-pyridyl)sulfonyl]-6-(o-tolyl)-2-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]pyridine-3-carboxamide (Compound 1766), N-[[6-(cyclohexylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidi- n-1-yl)pyridine-3-carboxamide (Compound 1767), 6-(6-ethoxy-4-methyl-2-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-(2,- 4,6-trimethylphenoxy)pyridine-3-carboxamide (Compound 1768), N-[(6-amino-2-pyridyl)sulfonyl]-2-[1-(1-naphthyl)ethylamino]pyridine-3-ca- rboxamide (Compound 1769), N-[[6-[(2,5-difluorophenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1770), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,5-dimethylphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1771), N-[(6-amino-2-pyridyl)sulfonyl]-2-[2-(o-tolyl)azepan-1-yl]pyridine-3-carb- oxamide (Compound 1772), tert-butyl 4-[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-2- -pyridyl]piperazine-1-carboxylate (Compound 1773), 6-(4-isopropoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1774), N-[[6-(1,3-benzothiazol-6-ylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1775), N-[[6-(3,4,4a,5,6,7,8,8a-octahydro-2H-quinolin-1-yl)-2-pyridyl]sulfonyl]-- 2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1776), N-[[6-[(5-phenylisoxazol-3-yl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1777), N-[[6-[(3-chloro-4-methoxy-phenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1778), 6-(3-fluoro-2-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1779), 6-(4-fluoro-3-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1780), N-((6-aminopyridin-2-yl)sulfonyl)-2-(2,5-dimethylpiperidin-1-yl)-6-(3-flu- oro-5-isobutoxyphenyl)nicotinamide, N-[[6-(3-ethynylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 1782), N-[(2-amino-3-pyridyl)sulfonyl]-6-[6-[2-(2-ethoxyethoxy)ethoxyl-5-methyl-- 3-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1783), 6-(2-chlorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1784), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(trifluoromethoxy)phenyl]-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1785), 6-(2,3-dimethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1786), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[2-[2-(2-isopropoxyethoxy)ethoxy]eth- oxyl-5-methyl-3-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3- -carboxamide (Compound 1787), N-[(6-amino-2-pyridyl)sulfonyl]-2-[2,2-dimethyl-4-(trifluoromethyl)pyrrol- idin-1-yl]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1788), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[[(4S)-2-oxa-5-azabicyclo[2.2.1]- heptan-5-yl]sulfonyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-ca- rboxamide (Compound 1789), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-fluorophenyl)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1790), 6-(3-chlorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1791), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-methoxyphenyl)-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 1792), N-[(2-amino-3-pyridyl)sulfonyl]-6-(5,5-dimethyl-2-oxo-cyclohexyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1793), N-[(6-amino-2-pyridyl)sulfonyl]-2-[3-(cyclopropylmethyl)-2,2-dimethyl-pyr- rolidin-1-yl]pyridine-3-carboxamide (Compound 1794), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-ethoxy-4-methyl-2-pyridyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 1795), N-[[6-(2,4,5-trifluoroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 1796), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,6-dimethylphenoxy)-6-[3-fluoro-5-(3-- hydroxy-2-methyl-propoxy)phenyl]pyridine-3-carboxamide (Compound 1797), N-[[6-[(2-fluorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 1798), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-[4-(trifluoromethyl)phenyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1799), N-[[6-(2-cyclohexylethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 1800), 6-(3,5-difluoro-4-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1801), 6-(3-ethoxy-2-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1802), 6-(2-naphthyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1803), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-isopropoxyphenyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1804), N-[[6-[3-(methoxymethyl)-1-piperidyl]-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1805), N-[[6-(2,4-dichlorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 1806), 6-(4-fluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1807), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-ethoxy-4-fluoro-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1808), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-isopropylphenyl)-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 1809), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1,2-dimethylpropoxy)-5-fluoro-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1810), 6-(4-methyl-1-naphthyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1811), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-[2-(2-ethoxyethoxy)ethoxyl-6-methyl-- 4-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1812), N-[[6-(4-fluorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1813), N-[[6-(1,3-benzodioxol-5-ylmethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1814), N-[(6-amino-2-pyridyl)sulfonyl]-5-[3-isopropoxy-5-(trifluoromethyl)phenyl- ]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1815), N-[[6-[4-(2-pyridyl)piperazin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1816), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-ethyl-2,4-dimethyl-pyrrolidin-1-yl)-- 6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1817) (Isomer 3, SR) N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-fluoro-4-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1818), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-fluoro-5-methyl-phenyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1819), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-hydroxyphenyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1820), N-((6-aminopyridin-2-yl)sulfonyl)-6-(3-fluoro-5-isobutoxyphenyl)-2-((1S,2- S,5S,6R)-3-azatricyclo[4.2.1.02,5]nonan-3-yl)nicotinamide (Compound 1821), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-ethoxyphenyl)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1822), N-[[6-(1H-indol-5-ylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 1823), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-cyanophenyl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1824), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,5-dimethoxyphenyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1825), N-[[6-(8-quinolylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1826), N-[[6-[benzyl(methyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 1827), N-[[6-(3-ethoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1828), N-[(2-amino-3-pyridyl)sulfonyl]-6-(m-tolyl)-2-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]pyridine-3-carboxamide (Compound 1829), 6-(5-fluoro-2-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1830), N-[[6-(3-chloro-4-fluoro-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 1831), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(2-pyridylsulfonyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1832), N-[[6-(1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)-2-pyridyl]sulfonyl]-2-(- 2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1833), N-[[6-(cyclopentoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-y- l)pyridine-3-carboxamide (Compound 1834), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-[2-meth- yl-5-(trifluoromethyl)-1-piperidyl]pyridine-3-carboxamide (Compound 1835), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(2-hydroxyphenyl)sulfonyl-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1836), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-(2,3,5-trifluorophenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1837), N-[(6-isoindolin-2-yl-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 1838), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3,5-dimethylphenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1839), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2-meth- ylazetidin-1-yl)pyridine-3-carboxamide (Compound 1840), N-[[6-(3-chloroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1841), N-[[6-[(1R)-1-phenylethoxy]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 1842), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-ethoxy-5-methyl-phenyl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1843), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isopropoxypyrazol-1-yl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1844), N-[(2-amino-3-pyridyl)sulfonyl]-6-[6-(diethylamino)-2-pyridyl]-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1845), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(2-cyclohexyl-1,2-dihydrox- yethyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-ethoxy-2-fluoro-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1847), 6-(2-ethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1848), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-cyanophenyl)-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 1849), N-[(2-amino-3-pyridyl)sulfonyl]-6-tetrahydropyran-4-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1850), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-4-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1851), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-benzyl-2,2-dimethyl-pyrrolidin-1-yl)- -6-tert-butyl-pyridine-3-carboxamide (Compound 1852), 6-(2,6-dimethoxy-3-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1853), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,4-difluorophenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1854), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,5-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1855) (Isomer 4) (SR), 6-(3-ethoxy-4-methyl-pyrazol-1-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1856), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1-naphthyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1857), 6-(2-fluoro-4-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1858), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-ethoxy-3-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1860), N-[(6-amino-2-pyridyl)sulfonyl]-5-(6-methoxy-2-pyridyl)-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1861), N-[[6-[(4-ethyl-2-pyridyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1862), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,4-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1863) (Isomer 4) (SR), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,5-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1864) (Isomer 3) (SS), N-[[6-(thiazol-2-ylmethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 1865), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-methoxy-2-methyl-3-pyridyl)-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1866), 6-(2-ethoxy-4-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1867), N-(benzenesulfonyl)-6-tetrahydropyran-2-yl-2-[(4S)-2,2,4-trimethylpyrroli- din-1-yl]pyridine-3-carboxamide (Compound 1868), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-5-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1869), N-[[6-[ethyl(2-methoxyethyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1870), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,4-dimethylphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1871), N-[[6-(2-chloroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1872), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluorophenyl)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1873), N-[[6-(3,4-dihydro-2H-pyran-2-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1874), N-[[6-(7-quinolyloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 1875), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(4-methoxyphenyl)sulfonyl-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1876), N-[[6-[(1-acetylindolin-5-yl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1877), 6-(3,5-dimethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1878), N-[[6-[3-(N-methylanilino)propylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1879), 6-(2-methoxy-3-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1880), N-[[6-[(E)-but-2-enoxy]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1881), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-isobutylsulfonyl-3,6-dihydro-2H-pyri- din-5-yl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1882), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(1,2-dihydroxy-3,3-dimethy- lbutyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-[[6-(3-methylcyclopentoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 1884), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-hydroxyphenyl)sulfonyl-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1885), N-[(6-amino-2-pyridyl)sulfonyl]-5-(6-methoxy-3-pyridyl)-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1886), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-[2,3,3,3-tetradeuterio-2-(trideuteri- omethyl)propoxy]pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyrid- ine-3-carboxamide (Compound 1887), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-bicyclo[2.2.1]hept-2-enyl)-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1888), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-isopropoxy-5-methyl-phenyl)-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1889), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,6-dimethylphenoxy)-6-[3-fluoro-5-(2-- hydroxy-2-methyl-propoxy)phenyl]pyridine-3-carboxamide (Compound 1890), N-[(6-amino-2-pyridyl)sulfonyl]-5-fluoro-6-(1-tetrahydropyran-4-ylethoxy)- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1891), N-[[6-(p-tolylmethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 1892), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(3R)-3-methoxypyrrolidin-1-yl]sulfonyl- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1893), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-isopentyloxyphenyl)-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1894), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-isobutoxypyrazol-1-yl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1895), 6-(3-isobutoxypyrazol-1-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1896), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2-isopropoxyphenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1897), N-[[6-(2-methylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1898), N-[[6-[(2-chloro-4-fluoro-phenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1899), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-[4-(trifluoromethyl)phenyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1900), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,3-dimethylazepan-1-yl)-6-(3-f- luoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1901), N-[[6-(4-isopropylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 1902), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-isopropoxyphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1903), 6-(4,5-difluoro-2-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1904), N-[[6-(1-phenylethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 1905), N-[[6-(2,3-dichloroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 1906), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(diethylamino)-5-methyl-2-pyridyl]-2- -(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1907), N-[[6-(cyclohexoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl- )pyridine-3-carboxamide (Compound 1908), N-[[6-(indan-5-ylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1909), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-fluoro-4-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1910), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1,2-dimethylpropyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1911), N-(benzenesulfonyl)-6-(4-isobutoxypyrazol-1-yl)-2-[(4S)-2,2,4-trimethylpy- rrolidin-1-yl]pyridine-3-carboxamide (Compound 1912), 6-(2,5-difluoro-4-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1913), 6-(3,4-difluoro-5-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfon- yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1914), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(diethylamino)-5-methyl-3-pyridyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1915), N-[(6-amino-2-pyridyl)sulfonyl]-5-[(E)-hex-1-enyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1916), N-[[6-(1-phenylethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 1917), N-[(6-amino-2-pyridyl)sulfonyl]-5-[3-(cyclopentoxy)phenyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1918), N-[[6-(1-cyclohexylethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 1919), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-methoxycyclohexen-1-yl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1920), N-[(6-amino-2-pyridyl)sulfonyl]-5-[2-(trifluoromethyl)phenyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1921), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-4-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1922), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-hydroxy-3,5-dimethyl-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1923), N-[[6-(4-ethoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 1924), 6-(3-fluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1925), N-[[6-(3-tert-butylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 1926), 6-(3-methoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1927), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethylazetidin-1-yl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1928), N-[[6-[(2,4-dichlorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1929), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-fluoro-3-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1930), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-ethoxy-4,5-dimethyl-phenyl)-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1931), N-[[6-(azepan-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl- )pyridine-3-carboxamide (Compound 1932), N-[[6-(3-isoquinolylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 1933), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-[3-(trifluoromethoxy)phenyl]-2-[(4S- )-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1934), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[[(3S)-pyrrolidin-3-yl]sulfamoyl]-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1935), N-[[6-(1-methylcyclopentoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 1936), N-[[6-[4-(1,3-dioxolan-2-ylmethyl)piperazin-1-yl]-2-pyridyl]sulfonyl]-2-(- 2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1937), N-[[6-(benzylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl- )pyridine-3-carboxamide (Compound 1938), N-[[6-(tetrahydropyran-2-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1939), N-[[6-[(3-methoxyphenyl)methyl-methyl-aminol-2-pyridyl]sulfonyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1940), N-[[6-(2-chloro-5-fluoro-anilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 1941), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-(1-piperidylsulfonyl)-3,6-dihydro-2H- -pyridin-5-vil-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxami- de (Compound 1942), N-[(6-amino-2-pyridyl)sulfonyl]-5-[3-(2-methoxyethoxymethyl)phenyl]-2-(2,- 2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1943), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-2-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1944), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-ethoxyphenyl)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1945), 6-(2-fluoro-5-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1946), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2,4-difluorophenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1947), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(2-ethoxyethoxy)-6-methyl-4-pyridyl]- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1948), N-[[6-(3-acetylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 1949), N-[(6-amino-2-pyridyl)sulfonyl]-5-[3-(trifluoromethyl)phenyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1950), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,5-dimethylphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1951), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1952), N-[[6-[[3-(trifluoromethyl)phenyl]methoxy]-2-pyridyl]sulfonyl]-2-(- 2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1953), 6-(2,5-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1954), N-[(6-tetralin-5-yloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 1955), N-(3,3-difluoropyrrolidin-1-yl)sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1956), N-[[6-[(5-chloro-3-pyridyl)oxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1957), N-[(2-amino-3-pyridyl)sulfonyl]-6-phenyl-2-[(4S)-2,2,4-trimethylpyrrolidi- n-1-yl]pyridine-3-carboxamide (Compound 1958), N-[[6-(2-methoxyanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 1959), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-[2-(trifluoromethyl)phenyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1960), N-((6-aminopyridin-2-yl)sulfonyl)-6-(3-fluoro-5-isobutoxyphenyl)-2-(3,5,5- -trimethylcyclopent-1-en-1-yl)nicotinamide N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-methoxyphenyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1962), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-chloro-5-methyl-phenyl)-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1963), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-ethoxy-5-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1964), N-[[6-[(2-methoxyphenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1965), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-cyclopentylethoxy)-5-fluoro-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1966), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2-fluoro-4-methyl-phenyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1967), N-[[6-[(2,4-dichlorophenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1968), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-isobutoxyphenyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1969), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-sec-butoxypyrazol-1-yl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1970), N-[[6-[(4-tert-butylcyclohexyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1971), N-[[6-[(3-methoxyphenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 1972), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2-isopropoxyethoxy)-5-methyl-3-pyri- dyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1973), N-((6-aminopyridin-2-yl)sulfonyl)-6-(tert-butyl)-2-(3-cyclopropyl-2,2-dim- ethylpyrrolidin-1-yl)nicotinamide, N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1975) N-[(2-acetamido-3-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1976) N-[[6-[4-(trifluoromethoxy)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1977), N-[[6-[methyl(phenethyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 1978), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-isobutoxyphenyl)-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 1979), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-methoxy-3-pyridyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1980), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-(2,4,5-trifluorophenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1981), 6-(1H-indol-5-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1982), N-[[6-[(2-chlorophenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1983), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-(3-chlorobenzoyl)-3,6-dihydro-2H-pyr- idin-5-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1984), N-[[6-(4-pentylpiperazin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 1985), N-[[6-(1,3-dihydrobenzo[de]isoguinolin-2-yl)-2-pyridyl]sulfonyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1986), N-[[6-(4-phenyl-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 1987), N-[[6-(3-methylcyclohexoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 1988), N-[[6-(2-quinolyloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 1989), 6-(2,5-dimethylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1990), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isopropylphenyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1991), N-[[6-(3-thienylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 1992), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,5-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 1993) (Isomer 2) (RS) N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,6-dimethoxyphenyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1994), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,5-- trimethyl-1-piperidyl)pyridine-3-carboxamide (Compound 1995), N-[[6-f[(1R)-1-cyclohexylethyl]amino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 1996), 6-[3-(hydroxymethyl)phenyl]-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1997), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,4-difluoro-5-methoxy-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1998), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-hydroxy-2-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 1999), 6-(2-fluoro-4-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2000), N-[[6-[(6-methylcyclohex-3-en-1-yl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2001), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(diethylamino)-4-methyl-2-pyridyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2002), N-[[6-(1H-indol-5-yloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2003), N-[[6-(2-thienylmethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2004), N-[[6-[methyl-[2-(3-pyridyl)ethyl]amino]-2-pyridyl]sulfonyl]-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2005), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,5-difluoro-2-methoxy-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2006), 6-(1-naphthyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2007), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,4-dimethoxypyrimidin-5-yl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2008), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-5-iodo-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2009), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isobutoxy-6-methyl-4-pyridyl)- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2010), N-[[6-(3,4,4a,5,6,7,8,8a-octahydro-1H-isoguinolin-2-yl)-2-pyridyl]- sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2011), N-[[6-[[3-(dimethylamino)phenyl]methoxy]-2-pyridyl]sulfonyl]-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2012), N-[[6-(1,3-benzodioxol-5-yloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2013), N-[(6-amino-2-pyridyl)sulfonyl]-5-[(E)-2-[4-(trifluoromethyl)phenyl]vinyl- ]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2014), N-[[6-(2-fluorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2015), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2-fluoro-5-methyl-phenyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2016), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,4-dimethylphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2017), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-ethoxy-5-fluoro-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2018), N-[[6-(2-cyclohexylpropoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2019), N-[(6-amino-2-pyridyl)sulfonyl]-6-[(1R)-1,2-dimethylpropoxy]-5-fluoro-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2020), N-[(2-amino-3-pyridyl)sulfonyl]-6-[2-(dimethylamino)pyrimidin-5-yl- ]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2021), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(3-cyclopropyl-2,2-- dimethyl-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2022) (Isomer 2, R or S stereoisomer), N-[[6-(4-phenylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2023), N-[[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,- 4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2024), N-[[6-(3,3-dimethylbutoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2025), N-[[6-(cyclopentylmethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2026), isopropyl 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-2-tert-butyl-6-[(4S)-2,2,4-tr- imethylpyrrolidin-1-yl]-3-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (Compound 2027), 6-(4-chlorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2028), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-[3-(trifluoromethoxy)phenyl]-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2029), N-[[6-(3-methyl-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2030), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-methoxyphenyl)-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2031), N-[[6-(tetrahydropyran-4-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2032), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-fluoro-6-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2033), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-hydroxy-5-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2034), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,4,5-trifluorophenyl)-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2035), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isobutylpyrazol-1-yl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2036), 6-(2,4-dimethylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2037), N-[[6-(3,3-dimethylcyclohexoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2038), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3,5,5-- trimethylcyclopenten-1-yl)pyridine-3-carboxamide (Compound 2039) (Isomer 2, R or S stereoisomer), N-[(2-amino-3-pyridyl)sulfonyl]-6-[2-(trifluoromethyl)phenyl]-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2040), N-[[6-(3,4-dimethoxyanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2041), 6-(3-fluoro-5-isobutoxy-phenyl)-N-pyrrolidin-3-ylsulfonyl-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2042), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-hydroxy-4-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2043), N-[[6-[cyclopropylmethyl(methyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2044), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2-fluorophenyl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2045), N-[(2-amino-3-pyridyl)sulfonyl]-6-(5-fluoro-2-hydroxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2046), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-hydroxy-5,5-dimethyl-cyclohexyl)-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2047) N-[(2-amino-3-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)phenyl]-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2048), N-[[6-[1-(1-naphthyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2049), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2-ethoxyphenyl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2050), 6-(2-ethoxy-5-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2051), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-fluoro-3-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2052), N-[[6-(cyclopentylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 2053), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1H-indol-6-yl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2054), N-[[6-[2-(trifluoromethyl)pyrrolidin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2055), N-[(6-amino-2-pyridyl)sulfonyl]-5-fluoro-6-[(3S)-tetrahydrofuran-3-viloxy- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2056), N-[[6-(1-methylcycloheptoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2057), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-ethyl-2,4-dimethyl-pyrrolidin-1-yl)-- 6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2058) (Isomer 2, RS), N-[[6-(1,7,7-trimethylnorbornan-2-yl)oxy-2-pyridyl]sulfonyl]-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2059), ethyl 3-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-- 2-pyridyl]amino]benzoate (Compound 2060), N-[[6-(3,4-dichlorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2061), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,4-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2062) (Isomer 3) (SS), N-[(6-amino-2-pyridyl)sulfonyl]-5-[(E)-2-cyclohexylvinyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2063), N-[[6-[(3-chlorophenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2064), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(hydroxymethyl)-5-methoxy-phenyl]-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2065), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-chlorophenyl)-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2066), 6-(5-fluoro-2-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2067), N-[[6-(2-pyridylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2068), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(2-cyclopentyl-1,2-dihydro- xyethyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2069) (Isomer 2), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-[2-(trifluoromethoxy)phenyl]-2-- [(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2070), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-ethoxy-5-fluoro-phenyl)-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2071), N-[[6-[2-(4-methoxyphenyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2072), 6-(2,3-dimethylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2073), N-[[6-(5-quinolylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2074), N-[(6-isopentyloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)- pyridine-3-carboxamide (Compound 2075), N-[[6-(4-cyanophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2076), N-[(2-amino-3-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)cyclohexyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2077) (Isomer 1, cis or trans stereoisomer), N-[[6-[(3S)-1-benzylpyrrolidin-3-yl]oxy-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2078), N-[(6-amino-2-pyridyl)sulfonyl]-6-[2-(2-isopropoxyethoxy)-6-methyl-4-pyri- dyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2079), 6-(4-methoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2080), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3,5,5-- trimethylcyclopenten-1-yl)pyridine-3-carboxamide (Compound 2081) (Isomer 1, R or S stereoisomer), N-[[6-[(4-methyl-2-pyridyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2082), N-[[6-(2-tert-butylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2083), 6-(3-fluoro-4-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2084), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-methyl-2-propoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2085), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-methoxy-5-methyl-3-pyridyl)-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2086), N-[[6-[4-(1-piperidyl)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2087), N-[(6-amino-2-pyridyl)sulfonyl]-5-[4-(hydroxymethyl)phenyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2088), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-isobutoxyphenyl)-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2089), N-[[6-[(2-methoxyphenyl)methyl-methyl-aminol-2-pyridyl]sulfonyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2090), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,6-dimethoxy-3-pyridyl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2091), N-(benzenesulfonyl)-6-phenyl-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyrid- ine-3-carboxamide (Compound 2092), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3,5-dimethylphenyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2093), N-[[6-(2-phenylpyrrolidin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2094), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-methyl-4-propoxy-phenyl)-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2095), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-cyanophenyl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2096), N-[(2-amino-3-pyridyl)sulfonyl]-6-norbornan-2-yl-2-[(4S)-2,2,4-trimethylp- yrrolidin-1-yl]pyridine-3-carboxamide (Compound 2097), N-[[6-(3,4-dihydro-1H-isoquinolin-2-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2098), N-[[6-[(2,4-difluorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2099), N-[(6-amino-2-pyridyl)sulfonyl]-6-(cyclopentoxy)-5-fluoro-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2100), 6-(6-methoxy-2-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2101), N-[[6-(4-fluoroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2102), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-ethoxy-6-fluoro-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2103), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,2-difluoro-1,3-benzodioxol-5-yl)-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2104), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,5-difluorophenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2105), N-[[6-(2,4,6-trifluoroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2106), N-[[6-(4-benzyl-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2107), N-[[6-(3-isopropylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2108), N-[[6-[(1S,2S)-2-methylcyclopentoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2109), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2,3-difluorophenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2110), N-[[6-[(1-phenylpyrazol-4-yl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2111), N-[(6-amino-2-pyridyl)sulfonyl]-5-[4-[1-(hydroxymethyl)cyclopropyl]phenyl- ]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2112), N-cyclopentylsulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2113), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-isobutylpyrazol-3-yl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2114), N-[[6-(2,3-dihydro-1,4-benzodioxin-3-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,- 2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2115), N-[[6-(3-methylpyrrolidin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2116), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(3-meth- ylazetidin-1-yl)pyridine-3-carboxamide (Compound 2117), N-[[6-[(4-pyrazol-1-ylphenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2118), N-[[6-(4-phenylbutylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2119), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(4-isopropoxyphenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2120), ethyl 4-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-- 2-pyridyl]amino]benzoate (Compound 2122), N-[[6-(3-benzylpyrrolidin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2123), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-fluoro-3-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2124), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1H-indol-5-yl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2125), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-methyl-1-naphthyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2126), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,5-dimethylphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2127), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-fluoroazetidin-1-yl)-6-(3-fluoro-5-i- sobutoxy-phenyl)pyridine-3-carboxamide (Compound 2128), tert-butyl 4-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-(2,2,4-trimethylpyrrolidin-- 1-yl)-3-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (Compound 2129), N-[[6-(1,1-dimethylbutoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2130), N-[[6-(tetrahydrofuran-2-ylmethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2131), N-[(2-amino-3-pyridyl)sulfonyl]-6-(p-tolyl)-2-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]pyridine-3-carboxamide (Compound 2132), N-(benzenesulfonyl)-6-(2-hydroxy-3-methyl-phenyl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2133), ethyl 3-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-(2,2,4-trimethylpyrrolidin-- 1-yl)-3-pyridyl]-4-methoxy-benzoate (Compound 2134), N-[[6-(3-methoxypropylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2135), N-[[6-(1-naphthylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2136), N-[[6-(2-methyl-2-pyrrol-1-yl-propoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2137), 6-(5-ethoxy-2-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2138), N-((6-aminopyridin-2-yl)sulfonyl)-6-(tert-butyl)-2-(2,2-dimethyl-3-(tetra- hydro-2H-pyran-4-yl)pyrrolidin-1-yl)nicotinamide, methyl 6-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-- 2-pyridyl]amino]pyridine-3-carboxylate (Compound 2140), N-[4-[3-(4-chlorophenyl)propyl]piperazin-1-yl]sulfonyl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2141), N-[[6-(3-tert-butylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2142), N-[[6-[3-(trifluoromethoxy)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2143), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-[3-(trifluoromethyl)phenyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2144), N-[[6-(4-chlorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2145), N-[[6-[2-(2-thienyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2146), N-[(6-cyclohex-2-en-1-yloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2147), 6-(2-hydroxy-4-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2148), N-[(2-amino-3-pyridyl)sulfonyl]-6-(5-ethoxy-2-fluoro-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2149), N-[(2-amino-3-pyridyl)sulfonyl]-6-isobutyl-2-[(4S)-2,2,4-trimethylpyrroli- din-1-yl]pyridine-3-carboxamide (Compound 2150), N-[[6-(2-naphthylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidi- n-1-yl)pyridine-3-carboxamide (Compound 2151), N-[[6-(3-methoxy-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 2152), 6-(4-isobutoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2153), 6-(3,4-dimethylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2154), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,3-difluoroazetidin-1-yl)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2155), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-isopropoxyphenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2156), N-[(6-amino-2-pyridyl)sulfonyl]-5-(1H-indazol-4-yl)-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2157), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-hydroxy-3-methoxy-phenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2158), 6-(2,4-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2159), N-[[6-[(4,6-dimethyl-2-pyridyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2160), N-[[6-[2-(3-thienyl)ethoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2161), 6-(2,3-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2162), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,3-dihydrobenzofuran-7-yl)-2-R(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2163), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-methoxyphenyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2164), N-[[6-(3-chloro-2-fluoro-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2165), N-[[6-(3,3-difluoropyrrolidin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2166), N-[(6-butoxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridi- ne-3-carboxamide (Compound 2167), N-[[6-[(3-methoxyphenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2168), N-[[6-(1,3-benzodioxol-5-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2169), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-isopropoxy-5-methyl-3-pyridyl)-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2170), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4,4-dimethylazepan-1-yl)-6-(3-fluoro-5- -isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2171), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-isopropylphenyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2172), N-[[6-(4-isopropylcyclohexoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2173), 6-(2-hydroxy-5-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2174), N-[[6-[4-(4-pyridylmethyl)piperazin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2175), 6-(o-tolyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trimethylpy- rrolidin-1-yl]pyridine-3-carboxamide (Compound 2176), N-[[6-(3-chloro-5-cyano-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2177), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,4-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2178) (Isomer 2) (RS), N-[[6-(2,5-dimethoxyanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2179), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-tert-butylphenyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2180), N-[[6-(2-thienylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 2181), N-[[6-[(4-chloro-2-fluoro-phenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2182), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-chlorophenyl)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2183), N-[(6-amino-2-pyridyl)sulfonyl]-5-(m-tolyl)-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2184), 6-(3-cyanophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2185), N-[[6-[(1S)-1-phenylethoxy]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2186), N-[[6-[(4-isopropylphenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2187), N-[[6-(cyclobutylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidi- n-1-yl)pyridine-3-carboxamide (Compound 2188), N-[(2-amino-3-pyridyl)sulfonyl]-6-(5-fluoro-2-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2189), N-[[6-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-pyridyl]sulfonyl]-2-(2,2,- 4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2190), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isobutoxypyrazol-1-yl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2191), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(3-hydroxy-2-methyl-propoxy)pyrazol-- 1-vii-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2192), N-[[6-[(1-methylindol-5-yl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2193), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isobutoxypyrazol-1-yl)-2-(6-methyl-8- -azaspiro[3.4]octan-8-yl)pyridine-3-carboxamide (Compound 2194) (Isomer 3), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,5-dimethoxyphenyl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2195), N-[[6-(1-methylbutylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2197), N-[[6-[(2-methyl-1,3-benzothiazol-5-yl)aminol-2-pyridyl]sulfonyl]-2-(2,2,- 4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2198), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-fluoro-2-methyl-phenyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2199), N-[[6-(isopropylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2200), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-isop- ropyl-2,2-dimethyl-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2201), N-[[6-(cyclooctylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2202), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-hydroxy-3-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2203), tert-butyl (2S)-1-[3-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-(3-fluoro-5-isobutoxy-- phenyl)-2-pyridyl]pyrrolidine-2-carboxylate (Compound 2204), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-fluoro-5-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2205), N-[[6-(2-phenoxyethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2206), 6-(4-ethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2207), N-[[6-(4-phenylpiperazin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2208), N-[(5-amino-3,3-difluoro-1-piperidyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-ph- enyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2209), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-chloro-5-isopropoxy-phenyl)-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2210), N-[(6-decalin-2-yloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 2211), N-[(6-amino-2-pyridyl)sulfonyl]-5-fluoro-6-[1-(4-pyridyl)ethoxyl-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2212), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2-ethyl-2,4-dimethyl-pyrrolidin-1-yl)-- 6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2213) (Isomer 1, RR), N-[[6-(4-ethoxyanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2214), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,5-dimethylisoxazol-4-yl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2215), tert-butyl (2R)-1-[3-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-(3-fluoro-5-isobutoxy-- phenyl)-2-pyridyl]pyrrolidine-2-carboxylate (Compound 2216), N-[[6-(2,4-dichloroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2217), N-[[6-[(2-methylcyclohexyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2218), 6-(3-fluoro-4-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2219), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-[3-(trifluoromethyl)phenyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2220), N-[[6-[1-(methoxymethyl)propylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2221), 6-(2-fluoro-3-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2222), N-[(2-amino-3-pyridyl)sulfonyl]-6-[4-(trifluoromethoxy)phenyl]-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2223), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(6-meth- yl-3-azabicyclo[3.1.1]heptan-3-yl)pyridine-3-carboxamide (Compound 2224), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2,3-dimethylphenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2225), N-[[6-[4-(1-methylbutyl)piperazin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2226), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-ethoxy-2,5-dimethyl-phenyl)-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2227), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(3S)-3-fluoropyrrolidin-1-yl]sulfonyl-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2228), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3,4-difluorophenyl)-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2229), N-[(6-amino-2-pyridyl)sulfonyl]-5-fluoro-6-isopropoxy-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2230), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1-isobutylpyrazol-4-yl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2231), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-hydroxy-5-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2232), N-[[6-(2,3-dimethoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2233), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-[4-(trifluoromethoxy)phenyl]-2-[(4S- )-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2234), 6-(3-ethoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2235), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,5-difluorophenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2236), N-(3,8-diazabicyclo[3.2.1]octan-3-ylsulfonyl)-6-(3-fluoro-5-isobutoxy-phe- nyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2237), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isobutoxy-5-methyl-pyrazol-1-yl)-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2238), N-[[6-(4-methoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2239), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-methoxyphenyl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2240), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-ethoxy-5-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2241), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-[3-(cyclopropylmethyl)-2,2- -dimethyl-pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2242), N-[[6-[(2-phenylacetyl)aminol-2-pyridyl]sulfonyl]-6-[1-(2-phenylacetyl)-3- ,6-dihydro-2H-pyridin-5-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridin- e-3-carboxamide (Compound 2243), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-methoxy-3-pyridyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2244), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(trifluoromethoxy)phenyl]-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2245), N-(benzenesulfonyl)-6-isobutyl-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyr- idine-3-carboxamide (Compound 2246), 6-[3-(hydroxymethyl)-5-methoxy-phenyl]-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl- ]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2247), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-ethoxy-4-methyl-pyrazol-1-yl)- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2248), N-[[6-(1,3-benzodioxol-4-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2249), N-[[6-(cyclohexylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2250), tert-butyl 2-[methyl-[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulf- amoyl]-2-pyridyl]amino]acetate (Compound 2251), N-[[6-(cycloheptoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-y- l)pyridine-3-carboxamide (Compound 2252), ethyl 4-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-- 2-pyridyl]amino]piperidine-1-carboxylate (Compound 2253), N-[[6-(4-pyrazin-2-ylpiperazin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2254), N-[(6-indolin-1-yl-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)- pyridine-3-carboxamide (Compound 2255), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-ethoxy-4-methyl-2-pyridyl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2256) N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-hydroxyphenyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2257), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-N-methyl-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2258), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3,5-difluorophenyl)-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2259), N-[[6-(6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-pyridyl]sulfonyl]-2-(- 2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2260), N-[[6-[[2-(trifluoromethyl)phenyl]methoxy]-2-pyridyl]sulfonyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2261), N-[[6-[2-(4-chlorophenyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2262), N-[[6-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-2-pyridyl]sulfonyl]-2-(2- ,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2263), N-[[6-[(3-chlorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2264), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2,2-dimethyl-3-tetrahydro- pyran-4-yl-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2266), 6-(3-isobutoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2267), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-methoxy-2-pyridyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2268), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(6-meth- yl-8-azaspiro[3.4]octaN-8-yl)pyridine-3-carboxamide (Compound 2269) (Isomer 2, R or S stereoisomer), N-[[6-(1-naphthylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidi- n-1-yl)pyridine-3-carboxamide (Compound 2270), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethyl-4-(trifluoromethyl)pyrrol- idin-1-yl)-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2271), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,5-difluorophenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2272), N-[[6-[(2-chlorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2273), N-[[6-(5-isoquinolylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2274), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-benzyl-2,2-dimethyl-pyrrolidin-1-yl)- pyridine-3-carboxamide (Compound 2275), N-[(3R)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2- -(p-tolyl)pyridine-3-carboxamide (Compound 2276), N-(benzenesulfonyl)-6-tetrahydrofuran-3-yl-2-[(4S)-2,2,4-trimethylpyrroli- din-1-yl]pyridine-3-carboxamide (Compound 2277), 6-(3-ethoxy-5-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2278), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[isobutyl(methyl)aminol-5-methyl-3-p- yridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2279), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-naphthyl)-2-[(4S)-2,2,4-trimethylpyr- rolidin-1-yl]pyridine-3-carboxamide (Compound 2280), N-[(6-amino-2-pyridyl)sulfonyl]-5-fluoro-6-[(3R)-tetrahydrofuran-3-yl]oxy- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2281), N-[[6-(3,5-difluoroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2282), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-isopropoxyphenyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2283), 6-(3,4-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2284), N-[[6-[4-(6-methyl-2-pyridyl)piperazin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2285), N-[[6-[(4-tert-butylphenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2286), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,3-dimethylphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2287), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-dimethylaminophenyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2288), N-[(6-amino-2-pyridyl)sulfonyl]-2-[cyclohexylmethyl(methyl)aminol-6-(3-fl- uoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2289), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1-isopropylpyrazol-4-yl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2290), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,3-difluorophenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2291), N-[[6-[4-(trifluoromethyl)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2292), N-[[6-(3,5-dimethoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2293), N-[[6-[(6-methyl-2-pyridyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2294), 6-(5-fluoro-2-hydroxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2295), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)phenyl]-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2296), N-[[6-(3-benzyl-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2297), N-[[6-(2-chlorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2298), N-[[6-[(3-cyanophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2299), 6-(2-hydroxy-3-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2300), 6-(6-ethoxy-4-methyl-2-pyridyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-(2,4,6-trim- ethylphenoxy)pyridine-3-carboxamide (Compound 2301), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,3-difluoro-4-methoxy-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2302), N-[(6-amino-2-pyridyl)sulfonyl]-5-(1-isobutylpyrazol-3-yl)-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2303), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-cyanophenyl)-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 2304), N-[[6-(2-ethylbutylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidi- n-1-yl)pyridine-3-carboxamide (Compound 2305), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-isopropoxy-6-methyl-4-pyridyl)-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2306), N-[[6-[butyl(methyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2307), N-[[6-(2-furylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2308), N-[[6-(2,6-dimethoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2309), N-[[6-[(2-methoxyphenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2310), N-[(2-amino-3-pyridyl)sulfonyl]-6-tetrahydropyran-3-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2311) N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-chlorophenyl)-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2312), N-[(6-amino-2-pyridyl)sulfonyl]-5-[3-(cyclopentoxy)-5-methyl-phenyl]-2-(2- ,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2313), N-[[6-(4-aminophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2314), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-[4-(trifluoromethyl)cyclohexyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2315), N-[[6-(3-cyano-4-fluoro-anilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2316), N-[(6-cyclopent-3-en-1-yloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2317), N-[[6-[[(1R)-1,2-dimethylpropyl]amino]-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2318), N-[(2-amino-3-pyridyl)sulfonyl]-6-[6-(dimethylamino)-3-pyridyl]-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2319), N-[[6-(3-methylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2320), (3S)-2-[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamo- yl]-2-pyridyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid (Compound 2321), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-tert-butyl-5-methyl-phenyl)-2- -(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2322), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-hydr- oxy-1-piperidyl)pyridine-3-carboxamide (Compound 2323), N-[[6-(2-methylmorpholin-4-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2324), N-[(3R)-3-aminopyrrolidin-1-yl]sulfonyl-2-(2-benzyl-2-methyl-pyrrolidin-1- -yl)-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2325) (Isomer 1, R or S stereoisomer), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-[2-(2-ethoxyethoxy)ethoxy]pyrazol-1-- yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2326), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(4-methoxyphenyl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2327), N-[[6-(4-acetylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2328), N-[[6-(2-tetrahydropyran-4-ylethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2329), N-[[6-(4-methyl-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2330), N-[(6-amino-5-hydroxy-2-pyridyl)sulfonyl]-2-(2,6-dimethylphenoxy)-6-(3-fl- uoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2331), N-[[6-(3-fluorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2332), N-[[6-(8-quinolyloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 2333), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4,5-difluoro-2-methoxy-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2334), tert-butyl N-[4-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoy- l]-2-pyridyl]amino]butyl]carbamate (Compound 2335), N-[[6-(4-methylcyclohexoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2336), N-[(6-amino-2-pyridyl)sulfonyl]-5-[4-(trifluoromethyl)phenyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2337), N-[[6-(1H-indol-4-yloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 2338), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(m-tolyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2339), N-[[6-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-2-pyridyl]sul- fonyl-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2340), N-[[6-(3,4-difluoroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2341), N-[[6-(cyclopropylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2342), N-[[6-[2-methoxyethyl(propyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2343), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[1-(3,3-dimethylbutanoyl)-- 3,6-dihydro-2H-pyridin-4-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridi- ne-3-carboxamide (Compound 2344), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-4-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2345), N-[[6-[isopentyl(methyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2346), 6-(3-fluoro-5-isobutoxy-phenyl)-N-f[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept- an-5-yl]sulfonyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carbox- amide (Compound 2347), 6-(3-fluoro-5-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2348), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-5-hydroxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2349), N-[[6-(2,2-difluoroethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2350), N-[(2-amino-3-pyridyl)sulfonyl]-6-tetrahydropyran-2-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2351) N-[(2-amino-3-pyridyl)sulfonyl]-6-(1-methylindol-5-yl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2352), N-[[6-(3-isopropoxyanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2353), N-[[6-(2-ethoxyethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2354), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-2-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2355), 6-(4-fluoro-2-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2356), N-[[6-(3,5-dimethoxyanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2357), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-2- -[6-methyl-8-azaspiro[3.4]octan-8-yl]pyridine-3-carboxamide (Compound 2358) (Isomer 1, R or S stereoisomer), N-[[6-[2-(2-pyridyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2359), 6-(3-isopropoxypyrazol-1-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2360), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-methylcyclohexen-1-yl)-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2361), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(isobutylamino)-5-methyl-2-pyridyl]-- 2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2362), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-methyl-3-pyridyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2363), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-ethoxy-6-methyl-4-pyridyl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2364), N-[[6-[[6-(trifluoromethyl)-2-pyridyl]methylamino]-2-pyridyl]sulfonyl]-2-- (2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2365), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(trifluoromethoxy)phenyl]-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2366), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-chlorophenyl)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2367), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-isopropylphenyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2368), 6-(4-methoxy-3-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2369), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(1,2-dihydroxy-3,3-dimethy- lbutyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-[[6-(cyclobutoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl- )pyridine-3-carboxamide (Compound 2371), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,4-difluorophenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2372), N-[(6-amino-2-pyridyl)sulfonyl]-6-(1-cyclopropylethoxy)-5-fluoro-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2373), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4,- 4-tetramethylcyclopentyl)pyridine-3-carboxamide (Compound 2374) (Isomer 2), N-[(6-amino-2-pyridyl)sulfonyl]-2-(cyclohexylmethylamino)-6-(3-fluoro- -5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2375), N-[(6-amino-2-pyridyl)sulfonyl]-2-(5-azabicyclo[4.1.0]heptan-5-yl)-6-(3-f- luoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2376), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-pyridylsulfonyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2377), N-[[6-[(3-chlorophenyl)methyl-methyl-aminol-2-pyridyl]sulfonyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2378), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-methoxy-4-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2379), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-methoxy-3-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2380), N-[[6-[3-(trifluoromethyl)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2381), N-[[6-(3,4-dihydro-2H-quinolin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2382), N-[[6-[4-(2-dimethylaminoethyl)-1-piperidyl]-2-pyridyl]sulfonyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2383), N-[(6-amino-2-pyridyl)sulfonyl]-5-(6-ethoxy-3-pyridyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2384), N-[[6-(5-chloroindolin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2385), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-2-hydroxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2386), N-[[6-(3-acetamidoanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2387), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,5-difluoro-4-methoxy-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2388), N-[[6-(1H-indazol-5-ylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2389), N-[[6-[(2,6-dichlorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2390), N-[[6-(m-tolylmethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2391), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-(trifluoromethyl)phenyl]-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2392), N-[[6-[(3S)-3-fluoropyrrolidin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2393), N-[(6-amino-2-pyridyl)sulfonyl]-6-(5-fluoro-2-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2394), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-isobutylphenyl)-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2395), N-[[6-(tetrahydrofuran-3-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2396), N-[[6-[2-(trifluoromethyl)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2397), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-hydroxy-3-methyl-azetidin-1-yl)sulfo- nyl-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2398), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-chlorophenyl)-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2399), tert-butyl N-methyl-N-[2-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl- ]sulfamoyl]-2-pyridyl]aminolethylicarbamate (Compound 2400), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1-methylindol-6-yl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2401), N-[[6-[(3,4-dichlorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2402), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-ethoxy-3-fluoro-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2403), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2-ethoxyethoxy)-5-methyl-3-pyridyl]- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2404), N-[(2-amino-3-pyridyl)sulfonyl]-6-[4-(2,2-dimethylpropoxy)pyrazol-- 1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2406), N-[[6-[(1-benzylpyrrolidin-3-yl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2407), N-[[6-[1-(2-fluorophenyl)ethoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2408), N-[[6-[(3-fluorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2409), 6-(2-ethoxy-5-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2410), N-(benzenesulfonyl)-6-(6-methoxy-2-pyridyl)-2-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]pyridine-3-carboxamide (Compound 2411), N-[[6-(2,2-dimethylpropoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2412), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-methoxy-5-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2413), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-fluorophenyl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2414), N-[[6-[(4-isopropylphenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2415), N-[(2-amino-3-pyridyl)sulfonyl]-6-[2-methyl-5-(trifluoromethyl)pyrazol-3-- yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2416), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[1-(2-phenylacetyl)-3,6-di- hydro-2H-pyridin-4-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-c- arboxamide (Compound 2417), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-isoquinolyl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2418), N-[[6-[(6-methoxy-2-pyridyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2420), N-[[6-[(3,5-difluorophenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2421), 6-(2-fluoro-6-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2422), N-[[6-(4-hexylpiperazin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 2423), 6-(m-tolyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trimethylpy- rrolidin-1-yl]pyridine-3-carboxamide (Compound 2424), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(2,2-dimethyl-3-tetrahydro- pyran-4-yl-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2425), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-hydroxy-5-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2426), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[(3R)-3-hydroxypyrrolidin-1-yl]sulfonyl- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2427), 6-tert-butyl-N-[[6-[(4-methoxyphenyl)methoxyl-2-pyridyl]sulfonyl]-- 2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2428) (Isomer 2), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-chlorophenyl)-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2429), N-[(6-methoxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyrid- ine-3-carboxamide (Compound 2430), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-fluoro-5-methoxy-phenyl)-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2431), N-[(2-amino-3-pyridyl)sulfonyl]-6-[4-(trifluoromethyl)cyclohexyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2432) (Isomer 2, cis or trans stereoisomer), N-[[6-(3-acetamidophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2433), N-[[6-[(1-methylcyclopropyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2434), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-fluorophenyl)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2435), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,3-dimethoxyphenyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2436), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-cyanophenyl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2437), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-(p-tolyl)-2-[(4S)-2,2,4-trimethylpy- rrolidin-1-yl]pyridine-3-carboxamide (Compound 2438), tert-butyl N-[4-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoy- l]-2-pyridyl]amino]cyclohexyl]carbamate (Compound 2439), 6-(3-methoxy-4-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2440), N-[[6-(4-imidazol-1-ylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2441), methyl 1-[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-2- -pyridyl]piperidine-4-carboxylate (Compound 2442), N-[[6-[3-(dimethylamino)phenoxy]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2443), 6-(5-fluoro-6-methoxy-3-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2444), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-phenyl-2-[(4S)-2,2,4-trimethylpyrro- lidin-1-yl]pyridine-3-carboxamide (Compound 2445), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-2-hydroxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2446), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,4-difluorophenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2447), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-isobutoxyphenyl)-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2448), N-[[6-(3-quinolylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2449), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-methoxy-2,3-dimethyl-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2450), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,5-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2451) (Isomer 1) (RR), N-[[6-[2-(4-piperidyl)ethoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 2452), N-[[6-(4-fluoro-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2453), 6-(2-methoxy-3-pyridyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2454), N-(benzenesulfonyl)-6-(6-ethoxy-4-methyl-2-pyridyl)-2-(2,4,6-trimethylphe- noxy)pyridine-3-carboxamide (Compound 2455), 6-(4-fluoro-3-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2456), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,5-difluoro-4-methoxy-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2457), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-[(2S)-2-methylbutoxy]pyrazol-1-yl]-2- -F(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2458), 6-(3-ethoxy-4-fluoro-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2459), N-[[6-(4-methylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2460), N-[[6-(3-chlorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2461), N-[[6-[(3,5-difluorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2462), N-[(6-amino-2-pyridyl)sulfonyl]-5-(4-tert-butylphenyl)-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2463), N-[(6-morpholino-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)py- ridine-3-carboxamide (Compound 2464), N-[[6-[2-(3-methoxyphenyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2465), N-[[6-[[6-(trifluoromethyl)-3-pyridyl]aminol-2-pyridyl]sulfonyl]-2-(2,2,4- -trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2466), 6-isobutyl-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trimethylpyr- rolidin-1-yl]pyridine-3-carboxamide (Compound 2467), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-hydroxy-2-naphthyl)-2-[(4S)-2,2,4-tr- imethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2468), 6-(4-methoxy-2-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2469), N-[[6-[(1R)-1-methyl-2-phenyl-ethoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2470), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(4-fluoro-3-methyl-phenyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2472), N-[(6-amino-2-pyridyl)sulfonyl]-5-fluoro-6-(3-fluoro-5-isobutoxy-phenyl)-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2473), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-fluoro-5-methoxy-phenyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2474), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(2-cyclohexyl-1,2-dihydrox- yethyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-[[6-[[6-(trifluoromethyl)-3-pyridyl]methoxyl-2-pyridyl]sulfonyl]-2-(2,2- ,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2476), N-[(3R)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-fluoro-5-isobutoxy-phenyl)-2- -(2-phenylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2477) (Isomer 2, R or S stereoisomer), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1H-indol-4-yl)-2-[(4S)-2,2,4-trimethyl- pyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2478), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,5-dimethylazepan-1-yl)-6-(3-fluoro-5- -isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2479), 6-(2-hydroxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2480), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isobutoxypyrazol-1-yl)-2-(6-methyl-8- -azaspiro[3.4]octan-8-yl)pyridine-3-carboxamide (Compound 2481) (Isomer 2, R or S stereoisomer), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-fluoro-2-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2482), 6-(4-isopropylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2483), N-[[6-(3-cyanoanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2484), 6-(2-methoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2485), N-[[6-(2-isopropylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2486), 6-(6-ethoxy-4-methyl-2-pyridyl)-N-(1H-pyrazol-3-ylsulfonyl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2487), ethyl 1-[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-2- -pyridyl]piperidine-4-carboxylate (Compound 2488), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2,5-difluorophenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2489), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(5-fluoro-2-methyl-phenyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2490), 6-(3-fluoro-2-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2491), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4,- 4-tetramethylcyclopentyl)pyridine-3-carboxamide (Compound 2492) (Isomer 1), methyl 3-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-- 2-pyridyl]amino]benzoate (Compound 2493), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-methoxy-2-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2494), tert-butyl 3-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-- 2-pyridyl]amino]propanoate (Compound 2495), 6-(3,5-difluoro-2-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2496), N-[(2-amino-3-pyridyl)sulfonyl]-6-[6-(2-ethoxyethoxy)-5-methyl-3-p- yridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2497), 6-(3-isopropylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2498), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-methoxy-5-methyl-phenyl)-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2499), N-[(2-amino-3-pyridyl)sulfonyl]-6-[6-(2,2-dimethylpropylamino)-2-pyridyl]- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2500), N-[(6-amino-2-pyridyl)sulfonyl]-2-[1-[2-(trifluoromethyl)phenyl]et- hoxy]pyridine-3-carboxamide (Compound 2501), N-[[6-[2-(p-tolyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 2502), N-[[6-(5-chloro-2-methoxy-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2503), N-[[6-[4-(2-pyridylmethyl)piperazin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2504), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-fluoro-5-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2505), methyl 4-[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-2- -pyridyl]piperazine-1-carboxylate (Compound 2506), N-[[6-(3-furylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2507), N-[(3,3-difluoro-5-hydroxy-1-piperidyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-- phenyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2508), N-[(6-phenoxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyrid- ine-3-carboxamide (Compound 2509), N-[(6-amino-2-pyridyl)sulfonyl]-5-[4-(trifluoromethyl)cyclohexen-1-yl]-2-- (2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2510), N-[(6-amino-2-pyridyl)sulfonyl]-6-(6-ethoxy-4-methyl-2-pyridyl)-2-(2,4,6-- trimethylphenoxy)pyridine-3-carboxamide (Compound 2511), 6-(3-ethoxy-5-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2512), N-[[6-(2,6-difluoroanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2513), N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-6-[2-(trifluoromethoxy)phenyl]-2-[(4S- )-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2514), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isopropoxyphenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2515), 6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2516), N-[[6-[3-(dimethylamino)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2517), N-[[6-(7-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2-pyridyl]sulfonyl]-2-(2- ,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2518), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[1-(cyclohexylcarbamoyl)-3- ,6-dihydro-2H-pyridin-4-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridin- e-3-carboxamide (Compound 2520) N-[(6-amino-2-pyridyl)sulfonyl]-5-[4-(1-cyano-1-methyl-ethyl)phenyl-2-(2,- 2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2521), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2522), N-[[6-(1-oxotetralin-6-yl)oxy-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 2523), N-[[6-[(4-fluorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2524), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(4-ethoxyphenyl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2525), N-[[6-(3-ethoxyanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2526), 6-(3-fluoro-5-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2527), N-[(6-propoxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyrid- ine-3-carboxamide (Compound 2528), N-[[6-(3-butoxypropylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2529), 6-(2-methoxy-5-methyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2530), N-[[6-[4-(diethylamino)anilino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2531), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3,4-dimethyl-1-piperidyl)-6-(3-fluoro-- 5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2532) (Isomer 1) (RR), N-[[6-[(3,4-difluorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2533), N-[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]sulfonyl-6-(3-fluoro-5-isobutoxy-- phenyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2534), N-[[6-(methylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl- )pyridine-3-carboxamide (Compound 2535), tert-butyl (2R)-1-[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamo- yl]-2-pyridyl]pyrrolidine-2-carboxylate (Compound 2536), tert-butyl N-[(3R)-1-[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulf- amoyl]-2-pyridyl]pyrrolidin-3-yl]carbamate (Compound 2537), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-tert-butyl-2,2-dimethyl-pyrrolidin-1- -yl)-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2538), N-[(2-amino-3-pyridyl)sulfonyl]-6-[2-(trifluoromethoxy)phenyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2539), 6-(4-chloro-3-propoxy-phenyl)-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-- yl]-N-[[6-(pent-4-ynoylamino)-2-pyridyl]sulfonyl]pyridine-3-carboxamide (Compound 2540), 6-(2-isopropoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2541), 6-(2-fluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2542), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(difluoromethoxy)-3-methyl-phenyl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2543), N-[(6-amino-2-pyridyl)sulfonyl]-2-[2-(1,3-benzoxazol-2-yl)phenoxy]- pyridine-3-carboxamide (Compound 2544), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-chloro-5-methoxy-phenyl)-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2545), N-[[6-(4-oxazol-5-ylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2546), N-[(6-amino-2-pyridyl)sulfonyl]-5-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-2-- (2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2547), 6-(3-isopropoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2549), N-[[6-[3-(3-methylpyrazol-1-yl)propylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2550), N-[[6-(3-methoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 2551), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(6-meth- yl-8-azaspiro[3.4]octan-8-yl)pyridine-3-carboxamide (Compound 2552), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-cyclopropylethyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2553) N-cyclopropylsulfonyl-6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2554), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-hydroxyphenyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2555), 6-(4-hydroxy-3,5-dimethyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2556), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-ethoxyphenyl)-2-(2,2,4-trimet- hylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2557), N-[(6-amino-2-pyridyl)sulfonyl]-5-(3-isobutoxy-5-methyl-phenyl)-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2558), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,4-difluorophenyl)-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2559), N-(benzenesulfonyl)-2-[(3S)-2,2-dideuterio-3,5,5-trimethyl-pyrrolidin-1-y- l]-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2560), N-[(6-pyrrolidin-1-yl-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 2561), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-fluoro-3-methoxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2562), N-[[6-(4-pyrrol-1-ylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2563), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-methoxy-5-methyl-3-pyridyl)-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2564), N-[[6-[4-(1-ethylpropyl)piperazin-1-yl]-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2565), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluorophenyl)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2566), 6-(2,3-difluoro-4-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2567), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-(tert-butylcarbamoyl)-3,6-dih- ydro-2H-pyridin-5-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-ca- rboxamide (Compound 2568), N-[[6-(3-acetylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2569), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-ethoxyphenyl)-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2570), N-[[6-(3-chloro-4-methoxy-anilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2571), N-[[6-(3-methylanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2572), N-[(6-amino-2-pyridyl)sulfonyl]-2-(2,2-dimethyl-4-(trifluoromethyl)pyrrol- idin-1-yl)-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide, N-[[6-(cyclopropylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 2574), 6-(4-methoxy-2,6-dimethyl-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2575), N-[(6-amino-2-pyridyl)sulfonyl]-6-[5-methyl-6-[(1R)-1-methylpropox- y]-3-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamid- e (Compound 2576), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-2-(3-cyclopropyl-2,2-dimethy- l-pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2577) (Isomer 1, R or S stereoisomer), 6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-N-[(2-oxo-1H-pyridin-3-yl)sulfony- l]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2578), N-[[6-[(4-methoxyphenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2579), N-[[6-(5-fluoroisoindolin-2-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2580), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(2,2,4-- trimethyl-1-piperidyl)pyridine-3-carboxamide (Compound 2581), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2-methoxyethoxy)-5-methyl-3-pyridyl- ]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2582), 6-(2,3-dihydrobenzofuran-7-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2583), N-[(6-amino-2-pyridyl)sulfonyl]-5-(2-cyanophenyl)-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2584), N-[[6-[(4-chlorophenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2585), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2,2-dimethylmorpholin-4-yl)-5-fluoro-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2586), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-fluoro-4-methyl-pheny- l)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2587), N-[(6-amino-2-pyridyl)sulfonyl]-5-(5-benzyloxy-2-methyl-phenyl)-2-- (2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2588), N-[(6-amino-2-pyridyl)sulfonyl]-2-(6,6-dimethyl-7-azaspiro[3.4]octan-7-yl- )-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2589), N-[(2-amino-3-pyridyl)sulfonyl]-6-[4-(hydroxymethyl)phenyl]-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2590), N-[[6-(2-chloro-5-fluoro-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2591), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-hydroxy-3-methyl-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2592), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(trifluoromethyl)phenyl]-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2593), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-2- -[6-methyl-8-azaspiro[3.4]octan-8-yl]pyridine-3-carboxamide (Compound 2594) (Isomer 2, R or S stereoisomer), N-[[6-(chroman-3-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2595), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-[1-(2-cyclohexylacetyl)-3,- 6-dihydro-2H-pyridin-4-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine- -3-carboxamide (Compound 2596), N-[[6-(2-furylmethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2597), N-[[6-(5-chloro-2-fluoro-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2598), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2-cyclohexylcyclohexyl)amino]pyridine- -3-carboxamide (Compound 2599), N-[[6-[(3-pyrrol-1-ylphenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2600), N-[[6-(4-cyclohexylpiperazin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethyl- pyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2601), N-[[6-(2-propoxyethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2602), N-[(6-amino-2-pyridyl)sulfonyl]-6-[4-(2,2-dimethylpropoxy)pyrazol-1-yl]-2- -[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2603), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-isobutoxypyrazol-1-yl)-2-(6-m- ethyl-8-azaspiro[3.4]octan-8-yl)pyridine-3-carboxamide (Compound 2604) (Isomer 1, R or S stereoisomer), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3,4-dimethylphenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2605), 6-(2-fluoro-5-methoxy-phenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2606), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-methoxy-2,6-dimethyl-phenyl)-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2607), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3,5-difluoro-4-isopropoxy-phenyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2608), N-[[6-(2-methylpyrrolidin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2609), N-[[6-[(4-ethynylphenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2610), N-[[6-(2-naphthyloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 2611), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-(2,2-dimethylbutanoyl)-3,6-dihydro-2- H-pyridin-5-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxam- ide (Compound 2612), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-fluoro-4-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2613), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-hydroxy-3-methoxy-phenyl)-2-[(4S)-2,- 2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2614), N-[(6-amino-2-pyridyl)sulfonyl]-2-(3-phenyl-1-piperidyl)pyridine-3-carbox- amide (Compound 2615), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-2-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2616), N-[(6-ethoxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyridi- ne-3-carboxamide (Compound 2617), N-[[6-[[4-(trifluoromethyl)phenyl]methoxy]-2-pyridyl]sulfonyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2618), N-[(6-benzyloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyr- idine-3-carboxamide (Compound 2619), N-[[6-(4-butyl-1,4-diazepan-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2620), N-[[6-(4-pyrimidin-2-ylpiperazin-1-yl)-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2621), isopropyl 5-[5-[(6-amino-2-pyridyl)sulfonylcarbamoyl]-6-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxylate (Compound 2622), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-isopropoxyphenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2623), isopropyl N-[6-[[6-(1,2,3,6-tetrahydropyridin-5-yl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carbonyl]sulfamoyl]-2-pyridyl]carbamate (Compound 2624), N-[[6-[2-(2-fluorophenyl)ethoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2625), 6-(3,5-dimethylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2626), N-[[6-(4H-1,3-benzodioxin-2-ylmethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2627), N-[(2-amino-3-pyridyl)sulfonyl]-6-(5-fluoro-6-methoxy-3-pyridyl)-2-[(4S)-- 2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2628), 6-(2-isobutoxyphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2629), N-[[6-(2-cyclopentylethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2630), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4,4-difluoro-2,2-dimethyl-pyrrolidin-1- -yl)-6-(3-fluoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2631), N-[[6-[2-(2-chlorophenyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2632), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-(2-cyclohexylacetyl)-3,6-dihydro-2H-- pyridin-5-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamid- e (Compound 2633), N-[(6-amino-2-pyridyl)sulfonyl]-3-fluoro-4-(3-fluoro-5-isobutoxy-phenyl)-- 2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]benzamide (Compound 2634) 6-(2-isopropylphenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-t- rimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2635), 6-(1H-indol-4-yl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-trime- thylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2636), N-[[6-(2-methoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin- -1-yl)pyridine-3-carboxamide (Compound 2637), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2638), N-[(6-anilino-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)pyrid- ine-3-carboxamide (Compound 2639), N-[[6-[(2,3-difluorophenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2640), N-[[6-[4-(trifluoromethyl)-1-piperidyl]-2-pyridyl]sulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2641), N-[[6-[2-(4-ethoxyphenyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2642), N-[[6-[(2-methyl-8-quinolyl)oxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2643), N-[(2-amino-3-pyridyl)sulfonyl]-6-[4-(difluoromethyl)phenyl]-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2644), N-[[6-[(5-chloro-2-methoxy-phenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2645), N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-methoxy-4-pyridyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2646), N-[(6-amino-2-pyridyl)sulfonyl]-5-[(E)-5-methylhex-1-enyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2647), N-[[6-(3-methylbut-2-enoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2648), N-[(6-amino-2-pyridyl)sulfonyl]-5-[4-(trifluoromethoxy)phenyl]-2-(2,2,4-t- rimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2649), N-[(6-amino-2-pyridyl)sulfonyl]-6-[1-(3,3-dimethylbutanoyl)-3,6-dihydro-2- H-pyridin-5-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxam- ide (Compound 2650), N-[(2-amino-3-pyridyl)sulfonyl]-6-(6-ethoxy-5-methyl-3-pyridyl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2651), 6-(3,5-difluorophenyl)-N-[(2-oxo-1H-pyridin-3-yl)sulfonyl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2652), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-fluoro-2-hydroxy-phenyl)-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2653), N-[[6-(2,4,6-trifluorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2654), 6-(3-fluoro-5-isobutoxy-phenyl)-N-(3-piperidylsulfonyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2655), N-[[6-[(5-chloro-2-pyridyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2656), tert-butyl 2-[5-[(2-amino-3-pyridyl)sulfonylcarbamoyl]-6-[(4S)-2,2,4-trimethylpyrrol- idin-1-yl]-2-pyridyl]indole-1-carboxylate (Compound 2657), N-[(6-amino-2-pyridyl)sulfonyl]-6-(4-isopropoxypyrazol-1-yl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2658), N-[[6-(2-cyanoanilino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2659), N-[(2-amino-3-pyridyl)sulfonyl]-6-(5-fluoro-2-methyl-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2660), N-[(6-amino-2-pyridyl)sulfonyl]-6-tert-butyl-5-(2-cyclopentyl-1,2-dihydro- xyethyl)-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2661) (Isomer 1), N-[[6-[(3,4-dimethoxyphenyl)methylamino]-2-pyridylsulfonyl]-2-(2,2,4-trim- ethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2662), N-[[6-(3,5-dichlorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2663), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3,4-dimethoxyphenyl)-2-[(4S)-2,2,4-tri- methylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2664), N-[(2-amino-3-pyridyl)sulfonyl]-6-(3-ethoxy-4-fluoro-phenyl)-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2665), N-[(3S)-3-aminopyrrolidin-1-yl]sulfonyl-6-(2-methoxyphenyl)-2-[(4S)-2,2,4- -trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2666), N-[(2-amino-3-pyridyl)sulfonyl]-6-(4-methoxyphenyl)-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2667), N-[(2-amino-3-pyridyl)sulfonyl]-6-(1,3,5-trimethylpyrazol-4-yl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2668), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-benzoyl-2,6-dimethyl-phenoxy)-6-(3-f- luoro-5-isobutoxy-phenyl)pyridine-3-carboxamide (Compound 2669), 6-[3-(2,2-dimethylpropoxy)pyrazol-1-yl]-N-[[2-(1-piperidyl)-3-pyridyl]sul- fonyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2670), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-2-(4-iodo- -2,6-dimethyl-phenoxy)pyridine-3-carboxamide (Compound 2671), N-[(2-amino-3-pyridyl)sulfonyl]-6-tetrahydropyran-2-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2672) (Isomer 1, RS or SS stereoisomer), N-cyclopropylsulfonyl-6-(3-phenylpyrazol-1-yl)-2-[(4S)-2,2,4-trimethylpyr- rolidin-1-yl]pyridine-3-carboxamide (Compound 2674), N-[(2-amino-3-pyridyl)sulfonyl]-6-tetrahydropyran-2-yl-2-[(4S)-2,2,4-trim- ethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2675) (Isomer 2, RS or SS stereoisomer), N-cyclopropylsulfonyl-2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]-6-(3-phenyl- pyrazol-1-yl)pyridine-3-carboxamide (Compound 2676), 6-(3-fluoro-5-isobutoxy-phenyl)-N-[[(3R)-3-piperidyl]sulfamoyl]-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2677), N-[(6-amino-2-pyridyl)sulfonyl]-6-(2-ethoxyethoxy)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2678), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-fluoro-5-isobutoxy-phenyl)-4-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2679), N--(((R)-3-((4-fluoro-3-(trifluoromethoxy)benzyl)amino)pyrrolidin-1-yl)su- lfonyl)-2-((S)-2,2,4-trimethylpyrrolidin-1-yl)nicotinamide, N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[2-(2-ethoxyethoxy)ethyl-methyl-amin- ol-5-methyl-3-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-c- arboxamide (Compound 2684), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[2-ethoxyethyl(methyl)aminol-5-methy- l-3-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2685), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(2-ethoxyethylamino)-5-methyl-3-pyri- dyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2686), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[isopropyl(methyl)aminol-5-methyl-3-- pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2687), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-(isopropylamino)-5-methyl-3-pyridyl]- -2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2688), N-[(6-amino-2-pyridyl)sulfonyl]-6-[6-[ethyl(methyl)aminol-5-methyl- -3-pyridyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2689), N-((2-aminopyridin-3-yl)sulfonyl)-6'-(((S)-1-hydroxypropan-2-yl)oxy)-6-((- S)-2,2,4-trimethylpyrrolidin-1-yl)-[2,3'-bipyridine]-5-carboxamide (Compound 2690), N-[(2-amino-6-methoxy-3-pyridyl)sulfonyl]-6-(6-isopropoxy-3-pyridyl)-2-[(- 4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2692), N--(((R)-3-((2,4-dichlorobenzyl)amino)pyrrolidin-1-yl)sulfonyl)-2-((S)-2,- 2,4-trimethylpyrrolidin-1-yl)nicotinamide (Compound 2689), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(cyclobutylmethoxy)pyrazol-1-yl]-2-[- (4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2694), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(cyclopropylmethoxy)pyrazol-1- -yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-((3-((4-(tert-butoxy)benzyl)amino)piperidin-1-yl)sulfonyl)-2-((S)-2,2,4- -trimethylpyrrolidin-1-yl)nicotinamide, N--(((R)-3-((4-(tert-butoxy)benzyl)amino)pyrrolidin-1-yl)sulfonyl)-2-((S)- -2,2,4-trimethylpyrrolidin-1-yl)nicotinamide, N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(2,2-dimethylpropoxy)-4-methyl-pyraz- ol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2699), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(cyclopropyl)pyrazol-1-yl]-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2695), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(phenyl)pyrazol-1-yl]-2-[(4S)-2,2,4-- trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-[3,3,3-trideuterio-2,2-bis(trideuter- iomethyl)propoxy]pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyri- dine-3-carboxamide (Compound 2703), (S)--N-((2-aminopyridin-3-yl)sulfonyl)-6-methoxy-2-(2,2,4-trimethylpyrrol- idin-1-yl)nicotinamide, N-[(2-amino-3-pyridyl)sulfonyl]-6-(2-ethoxyethoxy)-2-[(4S)-2,2,4-trimethy- lpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2705), N-[(2-amino-3-pyridyl)sulfonyl]-6-[2-(2-ethoxyethoxy)ethoxyl-2-[(4S)-2,2,- 4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2706), 6-(3,5-dimethylphenyl)-N-[(6-isopentyloxy-2-pyridyl)sulfonyl]-2-[(4S)-2,2- ,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2707), N-[(6-amino-2-pyridyl)sulfonyl]-6-[3-fluoro-5-[2,3,3,3-tetradeuterio-2-(t- rideuteriomethyl)propoxy]phenyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]py- ridine-3-carboxamide (Compound 2708), N-[(6-amino-2-pyridyl)sulfonyl]-6-(3-bicyclo[2.2.1]hept-2-enyl)-2-[(4S)-2- ,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2709), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(1-methylpropoxy)pyrazol-1-yl]-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2704), N-[(2-amino-3-pyridyl)sulfonyl]-6-[3-(1-methylpropoxy)pyrazol-1-yl]-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2704), N-(benzenesulfonyl)-6-[3-fluoro-5-[2,3,3,3-tetradeuterio-2-(trideuteriome- thyl)propoxy]phenyl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-car- boxamide (Compound 2713), N-[(6-amino-2-pyridyl)sulfonyl]-2-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-6- -[6-[1,2,2,2-tetradeuterio-1-(trideuteriomethyl)ethoxyl-3-pyridyl]pyridine- -3-carboxamide (Compound 2714), N-[(6-amino-2-pyridyl)sulfonyl]-2-(4-benzoyl-2,6-dimethyl-phenoxy)-6-(6-i- sopropoxy-3-pyridyl)pyridine-3-carboxamide (Compound 2715), N-[(3R)-3-aminopyrrolidin-1-yl]sulfonyl-6-(3-isobutoxypyrazol-1-yl)-2-[(4- S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2716), N-[(3R)-3-[3-(4-chlorophenyl)propylamino]pyrrolidin-1-yl]sulfonyl-2-[(4S)- -2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, N-cyclopropylsulfonyl-6-[3-(2-pyridyl)pyrazol-1-yl]-2-[(4S)-2,2,4-trimeth- ylpyrrolidin-1-yl]pyridine-3-carboxamide (Compound 2718), 6-(tert-butyl)-N-((6-((4-methoxybenzyl)amino)pyridin-2-yl)sulfonyl)-2-(2,- 2,4-trimethylpyrrolidin-1-yl)nicotinamide, 6-tert-butyl-N-[[6-[(4-methoxyphenyl)methoxyl-2-pyridyl]sulfonyl]-2-(2,2,- 4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2724), N-[[6-(1,3-benzodioxol-5-ylmethoxy)-2-pyridyl]sulfonyl]-6-tert-butyl-2-(2- ,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2725), N-[[6-[(E)-but-2-enoxy]-2-pyridyl]sulfonyl]-6-tert-butyl-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2726), a 6-tert-butyl-N-[(6-isopentyloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2727), N-[[6-(3-chloro-5-fluoro-phenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylp- yrrolidin-1-yl)pyridine-3-carboxamide (Compound 2730), N-[[6-(2,3-dichlorophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrroli- din-1-yl)pyridine-3-carboxamide (Compound 2731), N-[(6-phenethyloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)- pyridine-3-carboxamide (Compound 2732), N-[[6-[(2,5-dimethoxyphenyl)methylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-tri- methylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2733), N-[[6-[cyclopropylmethyl(propyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2734), N-[[6-[isopropyl(methyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2735), N-[[6-[cyclopropylmethyl(propyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trime- thylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2734), N-[[6-[isopropyl(methyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2735), N-[[6-(3-cyanophenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1- -yl)pyridine-3-carboxamide (Compound 2736), N-[[6-(diethylamino)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-y- l)pyridine-3-carboxamide (Compound 2737), N-[[6-(2,1,3-benzoxadiazol-5-yloxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethy- lpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2738), methyl 4-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoyl]-- 2-pyridyl]oxy]benzoate (Compound 2739), N-[[6-[(2-methyl-1,3-benzothiazol-5-yl)oxyl-2-pyridyl]sulfonyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2740), N-[[6-(4-acetylphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-- 1-yl)pyridine-3-carboxamide (Compound 2741), N-[[6-[(6-methyl-2-pyridyl)oxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2742), N-[[6-(4-methoxy-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 2743), N-[[6-(1-oxoindan-5-yl)oxy-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolid- in-1-yl)pyridine-3-carboxamide (Compound 2744), N-[[6-[3-methoxypropyl(methyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimeth- ylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2745), N-[[6-[2-(4-pyridyl)ethylamino]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2746), N-[[6-[(5-chloro-2-pyridyl)oxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyr- rolidin-1-yl)pyridine-3-carboxamide (Compound 2747), N-[(6-chroman-4-yloxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 2749), N-[[6-[2-(1-piperidyl)phenoxy]-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrr- olidin-1-yl)pyridine-3-carboxamide (Compound 2750), N-[[6-(4-tert-butoxyphenoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2751), N-[[6-[2-(3-fluorophenyl)ethoxyl-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpy- rrolidin-1-yl)pyridine-3-carboxamide (Compound 2752), N-[(6-but-2-ynoxy-2-pyridyl)sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-yl)p- yridine-3-carboxamide (Compound 2753), N-[[6-(2-aminoethoxy)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrolidin-1-- yl)pyridine-3-carboxamide (Compound 2754), tert-butyl N-[4-[[6-[[2-(2,2,4-trimethylpyrrolidin-1-yl)pyridine-3-carbonyl]sulfamoy- l]-2-pyridyl]amino]phenyl]carbamate (Compound 2755), N-[[6-[(2-chlorophenyl)methyl-methyl-aminol-2-pyridyl]sulfonyl]-2-(2,2,4-- trimethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2756), N-[[6-[[(1R)-1,2,2-trimethylpropyl]amino]-2-pyridyl]sulfonyl]-2-(2,2,4-tr- imethylpyrrolidin-1-yl)pyridine-3-carboxamide (Compound 2757), N-[[6-[isobutyl(methyl)aminol-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrro- lidin-1-yl)pyridine-3-carboxamide (Compound 2758), N-[[6-(2-methyl-1-piperidyl)-2-pyridyl]sulfonyl]-2-(2,2,4-trimethylpyrrol- idin-1-yl)pyridine-3-carboxamide (Compound 2759), pharmaceutically acceptable salts thereof, and deuterated derivatives of any of the foregoing. 29. A pharmaceutical composition comprising the compound, salt, or deuterated derivative of claim 1 and a pharmaceutically acceptable carrier. 30. The pharmaceutical composition of claim 29, further comprising one or more additional therapeutic agent(s). 31. The pharmaceutical composition of claim 30, wherein the one or more additional therapeutic agent(s) comprises a CFTR modulator. 32. The pharmaceutical composition of claim 30, wherein the one or more additional therapeutic agent(s) comprises ##STR03811## or pharmaceutically acceptable salt thereof. 33. The pharmaceutical composition of claim 30, wherein the one or more additional therapeutic agent(s) comprises ##STR03812## or pharmaceutically acceptable salt thereof. 34. The pharmaceutical composition of claim 30, wherein the one or more additional therapeutic agent(s) comprises ##STR03813## or pharmaceutically acceptable salts thereof. 35. A method of treating cystic fibrosis in a patient comprising administering to the patient an effective amount of the compound, salt, or deuterated derivative of claim 1. 36. The method of claim 35, further comprising administering to the patient one or more additional therapeutic agent(s) prior to, concurrent with, or subsequent to the compound, salt, or deuterated derivative. 37. The method of claim 36, wherein the one or more additional therapeutic agent(s) comprises a CFTR modulator. 38. The method of claim 36, wherein the one or more additional therapeutic agent(s) comprises ##STR03814## or a pharmaceutically acceptable salt thereof. 39. The method of claim 36, wherein the one or more additional therapeutic agent(s) comprises ##STR03815## or a pharmaceutically acceptable salt thereof. 40. The method of claim 35, wherein the patient is homozygous in the F508del mutation. 41. The method of claim 35, wherein the patient is heterozygous in the F508del mutation. 42. A method of treating cystic fibrosis in a patient comprising administering to the patient an effective amount of the pharmaceutical composition of claim 29. 43. The method of claim 42, further comprising administering to the patient one or more additional therapeutic agent(s) prior to, concurrent with, or subsequent to the pharmaceutical composition. 44. The method of claim 43, wherein the one or more additional therapeutic agent(s) comprises a CFTR modulator. 45. The method of claim 43, wherein the one or more additional therapeutic agent(s) comprises ##STR03816## or a pharmaceutically acceptable salt thereof. 46. The method of claim 43, wherein the one or more additional therapeutic agent(s) comprises ##STR03817## or a pharmaceutically acceptable salt thereof. 47. The method of claim 43, wherein the one or more additional therapeutic agent(s) comprises ##STR03818## or pharmaceutically acceptable salts thereof.