Claims for Patent: 11,357,753

Summary for Patent: 11,357,753

Title:	Rescue treatment of post operative nausea and vomiting
Abstract:	Amisulpride is useful in the treatment of postoperative nausea and/or vomiting in a patient, wherein the patient has already been administered a prophylaxis drug for postoperative nausea and/or vomiting, and wherein the dose of amisulpride is 7.5 to 15 mg.
Inventor(s):	Gilbert; Julian Clive (Cambridge, GB), Gristwood; Robert William (Cambridge, GB), Fox; Gabriel (Cambridge, GB)
Assignee:	Acacia Pharma Ltd (Duxford, GB)
Application Number:	16/485,008
Patent Claims:	1. A method for treating postoperative nausea and/or vomiting (PONV) in a patient, comprising administering amisulpride to the patient at a dose of 10 mg, wherein the patient has been administered a prophylaxis drug for PONV, undergone a surgical procedure, and experienced PONV prior to the administration of amisulpride, and wherein the prophylaxis drug is not amisulpride. 2. The method of claim 1, wherein the prophylaxis drug is not a dopamine-2 (D.sub.2) antagonist. 3. The method of claim 1, wherein the prophylaxis drug is an anti-emetic selected from a 5HT.sub.3-antagonist, a corticosteroid, an anti-histamine (H1), an anti-cholinergic, a H.sub.2-antagonist and a NK.sub.1-antagonist. 4. The method of claim 1, wherein the amisulpride is administered in combination with another anti-emetic, either sequentially or simultaneously. 5. The method of claim 4, wherein the another anti-emetic is a 5HT.sub.3 antagonist, an NK.sub.1 antagonist or a steroid. 6. The method of claim 5, wherein the another anti-emetic is dexamethasone, ondansetron, granisetron, palonosetron, aprepitant, netupitant or rolapitant. 7. The method of claim 1, wherein the amisulpride is substantially in the form of a racemate. 8. The method of claim 1, wherein the amisulpride is administered via the intravenous route.