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Last Updated: May 14, 2024

Claims for Patent: 11,103,497

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Summary for Patent: 11,103,497

Title:	Treatment of imatinib resistant leukemia
Abstract:	The present invention provides 4-anilino-3-quinolinecarbonitriles compounds useful for treating a subject having an BcrAbl positive leukemia that is resistant to imatinib.
Inventor(s):	Hewes; Becker (Middlesex, MA)
Assignee:	Wyeth LLC (New York, NY)
Application Number:	12/129,935
Patent Claims:	1. A method for treating a BcrAbl positive leukemia in a subject that is resistant to imatinib which comprises administering to the subject a therapeutically effective amount of 4-[(2,4-Dichloro-5-methoxy-phenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piper- azinyl)propoxy]-3-quinolinecarbonitrile, wherein the subject has a mutation in BcrAbl protein at F317L. 2. A method for treating a BcrAbl positive leukemia in a subject that is resistant to imatinib which comprises administering to the subject a therapeutically effective amount of 4-[(2,4-Dichloro-5-methoxy-phenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piper- azinyl)propoxy]-3-quinolinecarbonitrile, wherein the subject has a resistance-associated nucleic acid mutation in the BcrAbl gene at 949T>C. 3. The method of claim 1, wherein the leukemia is Chronic Myelogenous Leukemia. 4. The method of claim 2, wherein the leukemia is Chronic Myelogenous Leukemia. 5. The method of claim 1, wherein the leukemia is Acute Lymphocytic Leukemia. 6. The method of claim 2, wherein the leukemia is Acute Lymphocytic Leukemia. 7. The method of claim 1, wherein the compounds are administered to the subject in combination with one or more other compounds used to treat a BcrAbl positive leukemia. 8. The method of claim 2, wherein the compounds are administered to the subject in combination with one or more other compounds used to treat a BcrAbl positive leukemia. 9. The method of claim 7, wherein the one or more other compounds includes imatinib. 10. The method of claim 8, wherein the one or more other compounds includes imatinib.

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