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Last Updated: June 5, 2024

Claims for Patent: 10,864,159

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Summary for Patent: 10,864,159

Title:	Method and composition for treating ocular hypertension and glaucoma
Abstract:	The present invention relates to an ophthalmic aqueous composition containing PGF2.alpha. analogues for treating ocular hypertension and glaucoma, to a method for treating ocular hypertension and glaucoma by administering said composition to a subject in need of such treatment, and to a method for increasing aqueous solubility and stability of PGF2.alpha. analogues in an aqueous composition.
Inventor(s):	Reunamaki; Timo (Tampere, FI), Pellinen; Pertti (Lempaala, FI), Oksala; Olli (Tampere, FI), Lehmussaari; Kari (Tampere, FI)
Assignee:	SANTEN PHARMACEUTICAL CO., LTD. (Osaka, JP) AGC INC. (Tokyo, JP)
Application Number:	16/010,739
Patent Claims:	1. A method for treating ocular hypertension and glaucoma to a subject in need thereof, by administrating an ophthalmic aqueous solution consisting of 0.0015% w/v tafluprost as an active ingredient, 0.075% w/v polysorbate 80, 0.05% w/v disodium edetate, 2.25% w/v glycerol, 0.2% w/v sodium dihydrogen phosphate dihydrate, one or more pH adjusters, and water. 2. A method for treating ocular hypertension and glaucoma to a subject in need thereof according to claim 1, wherein the ophthalmic aqueous solution is packaged in a single dose or unit dose container. 3. A method for treating ocular hypertension and glaucoma to a subject in need thereof according to claim 1, wherein the ophthalmic aqueous solution is packaged in a container made of a low density polyethylene. 4. A method for treating ocular hypertension and glaucoma to a subject in need thereof according to claim 2, wherein the container is made of a low density polyethylene. 5. A method for treating ocular hypertension and glaucoma to a subject in need thereof according to claim 4, wherein the container contains no more than 10% of any material other than polyethylene.

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